Engrailed is required in maturing serotonin neurons to regulate the cytoarchitecture and survival of the dorsal raphe nucleus

Analysis of constitutive Engrailed (En) null mice previously implicated the two En homeobox paralogs in the development of serotonin (5-HT) neurons. An unresolved question is whether En plays intrinsic roles in these neurons. Here, we show that En1 and En2 are expressed in maturing 5-HT neurons that...

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Veröffentlicht in:	The Journal of neuroscience 2012-06, Vol.32 (23), p.7832-7842
Hauptverfasser:	Fox, Stephanie R, Deneris, Evan S
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Animals Animals, Newborn Cell Count Cell Death - genetics Cell Death - physiology Cell Survival Chromatography, High Pressure Liquid Fluorescent Antibody Technique Homeodomain Proteins - genetics Homeodomain Proteins - physiology Immunohistochemistry Mice Mice, Knockout Mitosis - genetics Mitosis - physiology Nerve Tissue Proteins - genetics Nerve Tissue Proteins - physiology Neurons - physiology Raphe Nuclei - cytology Raphe Nuclei - physiology Real-Time Polymerase Chain Reaction RNA - genetics Serotonin - physiology
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