Social, communication, and cortical structural impairments in Epac2-deficient mice

Deficits in social and communication behaviors are common features of a number of neurodevelopmental disorders. However, the molecular and cellular substrates of these higher order brain functions are not well understood. Here we report that specific alterations in social and communication behaviors...

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Veröffentlicht in:	The Journal of neuroscience 2012-08, Vol.32 (34), p.11864-11878
Hauptverfasser:	Srivastava, Deepak P, Jones, Kelly A, Woolfrey, Kevin M, Burgdorf, Jeffrey, Russell, Theron A, Kalmbach, Abigail, Lee, Hyerin, Yang, Connie, Bradberry, Mazdak M, Wokosin, David, Moskal, Joseph R, Casanova, Manuel F, Waters, Jack, Penzes, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Dendritic Spines - genetics Dendritic Spines - physiology Exploratory Behavior - physiology Female Green Fluorescent Proteins - metabolism Guanine Nucleotide Exchange Factors - deficiency Guanine Nucleotide Exchange Factors - genetics Locomotion - genetics Male Maze Learning - physiology Mice Mice, Inbred C57BL Mice, Transgenic Neurons - cytology Social Behavior Somatosensory Cortex - cytology Statistics, Nonparametric Vocalization, Animal - physiology
Online-Zugang:	Volltext
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