The Locus Coeruleus-Norepinephrine Network Optimizes Coupling of Cerebral Blood Volume with Oxygen Demand

Given the brain's uniquely high cell density and tissue oxygen levels bordering on hypoxia, the ability to rapidly and precisely match blood flow to constantly changing patterns in neural activity is an essential feature of cerebrovascular regulation. Locus coeruleus-norepinephrine (LC-NE) proj...

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Veröffentlicht in:	Journal of cerebral blood flow and metabolism 2012-12, Vol.32 (12), p.2135-2145
Hauptverfasser:	Bekar, Lane K, Wei, Helen S, Nedergaard, Maiken
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha 2-Adrenergic receptors Alzheimer Disease - blood Alzheimer Disease - physiopathology Alzheimer's disease Anesthesia Animals Biological and medical sciences Blood Flow Velocity Blood Volume Brain Cell density Cerebral blood flow Cerebrovascular Circulation Cortex (somatosensory) Cortex (temporal) Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy hyperemia Hyperemia - blood Hyperemia - physiopathology Hypoxia Locus Coeruleus - metabolism Locus Coeruleus - physiopathology Male Medical sciences Mice Movement disorders Nervous system (semeiology, syndromes) Neurodegenerative diseases Neuroimaging Neurology Neurons Norepinephrine - blood Original Oxygen Oxygen - blood Parkinson Disease - blood Parkinson Disease - physiopathology Parkinson's disease Somatosensory Cortex - blood supply Somatosensory Cortex - metabolism Somatosensory Cortex - physiopathology Synchronization Vascular diseases and vascular malformations of the nervous system Vasoconstriction
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