Radiosurgery for epilepsy: Clinical experience and potential antiepileptic mechanisms
Summary Stereotactic radiosurgery, well established in the noninvasive treatment of focal lesions that are otherwise difficult to access through open surgery, is an emerging technology in the treatment of focal epileptic lesions. Recent studies suggest that seizures from hypothalamic hamartomas and...
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| Veröffentlicht in: | Epilepsia (Copenhagen) 2012-01, Vol.53 (1), p.7-15 |
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| creator | Quigg, Mark Rolston, John Barbaro, Nicholas M. |
| description | Summary
Stereotactic radiosurgery, well established in the noninvasive treatment of focal lesions that are otherwise difficult to access through open surgery, is an emerging technology in the treatment of focal epileptic lesions. Recent studies suggest that seizures from hypothalamic hamartomas and mesial temporal lobe epilepsy remit at clinically significant rates with radiosurgery, but large variations among different studies have raised questions about appropriate treatment protocols and mechanisms. Proposed anticonvulsant mechanisms include neuromodulatory effects or ischemic necrosis of epileptic tissue. An ongoing trial that directly compares efficacy, morbidities, and cost of radiosurgery versus open surgery for mesial temporal lobe epilepsy is underway. |
| doi_str_mv | 10.1111/j.1528-1167.2011.03339.x |
| format | Article |
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Stereotactic radiosurgery, well established in the noninvasive treatment of focal lesions that are otherwise difficult to access through open surgery, is an emerging technology in the treatment of focal epileptic lesions. Recent studies suggest that seizures from hypothalamic hamartomas and mesial temporal lobe epilepsy remit at clinically significant rates with radiosurgery, but large variations among different studies have raised questions about appropriate treatment protocols and mechanisms. Proposed anticonvulsant mechanisms include neuromodulatory effects or ischemic necrosis of epileptic tissue. An ongoing trial that directly compares efficacy, morbidities, and cost of radiosurgery versus open surgery for mesial temporal lobe epilepsy is underway.</description><identifier>ISSN: 0013-9580</identifier><identifier>EISSN: 1528-1167</identifier><identifier>DOI: 10.1111/j.1528-1167.2011.03339.x</identifier><identifier>PMID: 22191545</identifier><identifier>CODEN: EPILAK</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Anticonvulsants ; Anticonvulsants - therapeutic use ; Anticonvulsants. Antiepileptics. Antiparkinson agents ; Biological and medical sciences ; Brain ; Clinical trials ; Epilepsy ; Epilepsy surgery ; Epilepsy, Temporal Lobe - drug therapy ; Epilepsy, Temporal Lobe - surgery ; Gamma Knife ; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy ; Humans ; Hypothalamus ; Ischemia ; Medical sciences ; Mesial temporal lobe epilepsy ; Morbidity ; Necrosis ; Neoplasia ; Nervous system (semeiology, syndromes) ; Neurology ; Neuropharmacology ; Partial seizure ; Pharmacology. Drug treatments ; Radiosurgery ; Radiosurgery - adverse effects ; Radiosurgery - methods ; Seizures ; Seizures - drug therapy ; Seizures - surgery ; Surgery ; Temporal lobe ; Treatment Outcome</subject><ispartof>Epilepsia (Copenhagen), 2012-01, Vol.53 (1), p.7-15</ispartof><rights>Wiley Periodicals, Inc. © 2011 International League Against Epilepsy</rights><rights>2015 INIST-CNRS</rights><rights>Wiley Periodicals, Inc. © 2011 International League Against Epilepsy.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6019-ac5d94bc25e16e2b629033b923c4402341f0f27af33a5853f96791efd412aa413</citedby><cites>FETCH-LOGICAL-c6019-ac5d94bc25e16e2b629033b923c4402341f0f27af33a5853f96791efd412aa413</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1528-1167.2011.03339.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1528-1167.2011.03339.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,778,782,883,1414,1430,27911,27912,45561,45562,46396,46820</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25506984$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22191545$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Quigg, Mark</creatorcontrib><creatorcontrib>Rolston, John</creatorcontrib><creatorcontrib>Barbaro, Nicholas M.</creatorcontrib><title>Radiosurgery for epilepsy: Clinical experience and potential antiepileptic mechanisms</title><title>Epilepsia (Copenhagen)</title><addtitle>Epilepsia</addtitle><description>Summary
Stereotactic radiosurgery, well established in the noninvasive treatment of focal lesions that are otherwise difficult to access through open surgery, is an emerging technology in the treatment of focal epileptic lesions. Recent studies suggest that seizures from hypothalamic hamartomas and mesial temporal lobe epilepsy remit at clinically significant rates with radiosurgery, but large variations among different studies have raised questions about appropriate treatment protocols and mechanisms. Proposed anticonvulsant mechanisms include neuromodulatory effects or ischemic necrosis of epileptic tissue. An ongoing trial that directly compares efficacy, morbidities, and cost of radiosurgery versus open surgery for mesial temporal lobe epilepsy is underway.</description><subject>Anticonvulsants</subject><subject>Anticonvulsants - therapeutic use</subject><subject>Anticonvulsants. Antiepileptics. Antiparkinson agents</subject><subject>Biological and medical sciences</subject><subject>Brain</subject><subject>Clinical trials</subject><subject>Epilepsy</subject><subject>Epilepsy surgery</subject><subject>Epilepsy, Temporal Lobe - drug therapy</subject><subject>Epilepsy, Temporal Lobe - surgery</subject><subject>Gamma Knife</subject><subject>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</subject><subject>Humans</subject><subject>Hypothalamus</subject><subject>Ischemia</subject><subject>Medical sciences</subject><subject>Mesial temporal lobe epilepsy</subject><subject>Morbidity</subject><subject>Necrosis</subject><subject>Neoplasia</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurology</subject><subject>Neuropharmacology</subject><subject>Partial seizure</subject><subject>Pharmacology. Drug treatments</subject><subject>Radiosurgery</subject><subject>Radiosurgery - adverse effects</subject><subject>Radiosurgery - methods</subject><subject>Seizures</subject><subject>Seizures - drug therapy</subject><subject>Seizures - surgery</subject><subject>Surgery</subject><subject>Temporal lobe</subject><subject>Treatment Outcome</subject><issn>0013-9580</issn><issn>1528-1167</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkl2L1DAUhoMo7rj6F6Qg4lVrTj7aRnBBh3VddlFRF8GbQyaT7mbsl0mrM__e1I7jx5W9SeE878k5PCEkAZpB_J5uMpCsTAHyImMUIKOcc5Vtb5HFoXCbLCgFnipZ0iNyL4QNpbTIC36XHDEGCqSQC3L1Xq9dF0Z_bf0uqTqf2N7Vtg-7Z8mydq0zuk7strfe2dbYRLfrpO8G2w4uFnQ8Zn5wJmmsudGtC024T-5Uug72wf48JlevTj8uX6eXb8_Oly8uU5NTUKk2cq3EyjBpIbdslTMVF1kpxo0QlHEBFa1YoSvOtSwlr1ReKLDVWgDTWgA_Jidz335cNXZt4lhe19h712i_w047_LvSuhu87r4hl6B4WcYGT_YNfPd1tGHAxgVj61q3thsDKkbjjSJnkXz0D7npRt_G7RAkFEwUgspIlTNlfBeCt9VhFqA4qcMNToZwMoSTOvypDrcx-vDPXQ7BX64i8HgP6BCtVF63xoXfnJQ0V6WI3POZ-x7F7P57ADx9dz79xXw6510Y7PaQ1_4LxtdTSPz05gxfXny4oDn7jIz_AGtlxDg</recordid><startdate>201201</startdate><enddate>201201</enddate><creator>Quigg, Mark</creator><creator>Rolston, John</creator><creator>Barbaro, Nicholas M.</creator><general>Blackwell Publishing Ltd</general><general>Wiley-Blackwell</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>5PM</scope></search><sort><creationdate>201201</creationdate><title>Radiosurgery for epilepsy: Clinical experience and potential antiepileptic mechanisms</title><author>Quigg, Mark ; Rolston, John ; Barbaro, Nicholas M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6019-ac5d94bc25e16e2b629033b923c4402341f0f27af33a5853f96791efd412aa413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Anticonvulsants</topic><topic>Anticonvulsants - therapeutic use</topic><topic>Anticonvulsants. Antiepileptics. Antiparkinson agents</topic><topic>Biological and medical sciences</topic><topic>Brain</topic><topic>Clinical trials</topic><topic>Epilepsy</topic><topic>Epilepsy surgery</topic><topic>Epilepsy, Temporal Lobe - drug therapy</topic><topic>Epilepsy, Temporal Lobe - surgery</topic><topic>Gamma Knife</topic><topic>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</topic><topic>Humans</topic><topic>Hypothalamus</topic><topic>Ischemia</topic><topic>Medical sciences</topic><topic>Mesial temporal lobe epilepsy</topic><topic>Morbidity</topic><topic>Necrosis</topic><topic>Neoplasia</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurology</topic><topic>Neuropharmacology</topic><topic>Partial seizure</topic><topic>Pharmacology. Drug treatments</topic><topic>Radiosurgery</topic><topic>Radiosurgery - adverse effects</topic><topic>Radiosurgery - methods</topic><topic>Seizures</topic><topic>Seizures - drug therapy</topic><topic>Seizures - surgery</topic><topic>Surgery</topic><topic>Temporal lobe</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Quigg, Mark</creatorcontrib><creatorcontrib>Rolston, John</creatorcontrib><creatorcontrib>Barbaro, Nicholas M.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Epilepsia (Copenhagen)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Quigg, Mark</au><au>Rolston, John</au><au>Barbaro, Nicholas M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Radiosurgery for epilepsy: Clinical experience and potential antiepileptic mechanisms</atitle><jtitle>Epilepsia (Copenhagen)</jtitle><addtitle>Epilepsia</addtitle><date>2012-01</date><risdate>2012</risdate><volume>53</volume><issue>1</issue><spage>7</spage><epage>15</epage><pages>7-15</pages><issn>0013-9580</issn><eissn>1528-1167</eissn><coden>EPILAK</coden><abstract>Summary
Stereotactic radiosurgery, well established in the noninvasive treatment of focal lesions that are otherwise difficult to access through open surgery, is an emerging technology in the treatment of focal epileptic lesions. Recent studies suggest that seizures from hypothalamic hamartomas and mesial temporal lobe epilepsy remit at clinically significant rates with radiosurgery, but large variations among different studies have raised questions about appropriate treatment protocols and mechanisms. Proposed anticonvulsant mechanisms include neuromodulatory effects or ischemic necrosis of epileptic tissue. An ongoing trial that directly compares efficacy, morbidities, and cost of radiosurgery versus open surgery for mesial temporal lobe epilepsy is underway.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>22191545</pmid><doi>10.1111/j.1528-1167.2011.03339.x</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Anticonvulsants Anticonvulsants - therapeutic use Anticonvulsants. Antiepileptics. Antiparkinson agents Biological and medical sciences Brain Clinical trials Epilepsy Epilepsy surgery Epilepsy, Temporal Lobe - drug therapy Epilepsy, Temporal Lobe - surgery Gamma Knife Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Humans Hypothalamus Ischemia Medical sciences Mesial temporal lobe epilepsy Morbidity Necrosis Neoplasia Nervous system (semeiology, syndromes) Neurology Neuropharmacology Partial seizure Pharmacology. Drug treatments Radiosurgery Radiosurgery - adverse effects Radiosurgery - methods Seizures Seizures - drug therapy Seizures - surgery Surgery Temporal lobe Treatment Outcome |
| title | Radiosurgery for epilepsy: Clinical experience and potential antiepileptic mechanisms |
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