Network physiology reveals relations between network topology and physiological function

The human organism is an integrated network where complex physiological systems, each with its own regulatory mechanisms, continuously interact, and where failure of one system can trigger a breakdown of the entire network. Identifying and quantifying dynamical networks of diverse systems with diffe...

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Veröffentlicht in:Nature communications 2012-02, Vol.3 (1), p.702-702, Article 702
Hauptverfasser: Bashan, Amir, Bartsch, Ronny P., Kantelhardt, Jan. W., Havlin, Shlomo, Ivanov, Plamen Ch
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container_issue 1
container_start_page 702
container_title Nature communications
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creator Bashan, Amir
Bartsch, Ronny P.
Kantelhardt, Jan. W.
Havlin, Shlomo
Ivanov, Plamen Ch
description The human organism is an integrated network where complex physiological systems, each with its own regulatory mechanisms, continuously interact, and where failure of one system can trigger a breakdown of the entire network. Identifying and quantifying dynamical networks of diverse systems with different types of interactions is a challenge. Here we develop a framework to probe interactions among diverse systems, and we identify a physiological network. We find that each physiological state is characterized by a specific network structure, demonstrating a robust interplay between network topology and function. Across physiological states, the network undergoes topological transitions associated with fast reorganization of physiological interactions on time scales of a few minutes, indicating high network flexibility in response to perturbations. The proposed system-wide integrative approach may facilitate the development of a new field, Network Physiology. Humans are a network of complex physiological systems, but quantifying these diverse systems is a challenge. This study presents a method to show that each physiological state is characterized by a specific network structure, demonstrating a connection between network topology and function.
doi_str_mv 10.1038/ncomms1705
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631/378/1385/519
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631/553
Adult
Female
Humanities and Social Sciences
Humans
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Models, Biological
multidisciplinary
Physiological Phenomena
Science
Science (multidisciplinary)
Signal Transduction
Sleep Stages - physiology
Young Adult
title Network physiology reveals relations between network topology and physiological function
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