B12 cofactors directly stabilize an mRNA regulatory switch

The crystal structures of two different cobalamin (vitamin B 12 )-binding riboswitches are determined; the structures reveal how cobalamin facilitates interdomain interactions to regulate gene expression. An alternative structure for riboswitches Small metabolites and ligands can affect gene express...

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Veröffentlicht in:	Nature (London) 2012-12, Vol.492 (7427), p.133-137
Hauptverfasser:	Johnson Jr, James E., Reyes, Francis E., Polaski, Jacob T., Batey, Robert T.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/200 631/337/2179 631/45/535 Analysis Analytical, structural and metabolic biochemistry Base Sequence Biological and medical sciences Calorimetry Crystallography, X-Ray Escherichia coli - genetics Fundamental and applied biological sciences. Psychology Gene Expression Regulation - drug effects Genetic regulation Humanities and Social Sciences Hydrogen Bonding - drug effects letter Ligands Messenger RNA Models, Molecular Molecular and cellular biology multidisciplinary Nucleic Acid Conformation - drug effects Properties Proteins Riboswitch - drug effects Riboswitch - genetics RNA, Bacterial - genetics RNA, Messenger - chemistry RNA, Messenger - drug effects RNA, Messenger - genetics RNA, Messenger - metabolism Science Structure Thermodynamics Vitamin B 12 - chemistry Vitamin B 12 - metabolism Vitamin B 12 - pharmacology Vitamin B12
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