Stimulation of Adrenal Chromaffin Cell Proliferation by Hypercalcemia Induced by Intravenous Infusion of Calcium Gluconate in Rats

Increased incidence of adrenal pheochromocytoma is frequently encountered in rat carcinogenicity studies. In some of the studies, the finding is judged to be due to a rat-specific mechanism of carcinogenesis caused by a disturbance of calcium homeostasis. However, direct evidence that the proliferat...

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Veröffentlicht in:	Journal of Toxicologic Pathology 2012, Vol.25(4), pp.281-285
Hauptverfasser:	Isobe, Kaori, Ito, Tsuneo, Komatsu, Shun-ichiro, Asanuma, Kentaro, Fujii, Etsuko, Kato, Chie, Adachi, Kenji, Kato, Atsuhiko, Sugimoto, Tetsuro, Suzuki, Masami
Format:	Artikel
Sprache:	eng
Schlagworte:	adrenal glands bromodeoxyuridine cell proliferation activity chromaffin cell hypercalcemia rat Short Communication
Online-Zugang:	Volltext
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