Lck regulates IL‐10 expression in memory‐like Th1 cells

The Src family kinase Lck is thought to facilitate Th2 differentiation; however, its role in Th1 cells has not been well explored. Using mice that lack Lck in mature T cells, we find that lck⁻/⁻ Th1 skewed cells have normal expression of T‐bet and produce IFN‐γ at WT levels. However, there is a 3‐fo...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	European journal of immunology 2010-11, Vol.40 (11), p.3210-3219
Hauptverfasser:	Kemp, Kyeorda L, Levin, Steven D, Stein, Paul L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Forkhead Transcription Factors - biosynthesis Forkhead Transcription Factors - genetics Forkhead Transcription Factors - immunology GATA3 Transcription Factor - biosynthesis GATA3 Transcription Factor - genetics GATA3 Transcription Factor - immunology Gene Expression Regulation - genetics Gene Expression Regulation - immunology IL‐10 Immunologic Memory - physiology Interferon-gamma - biosynthesis Interferon-gamma - genetics Interferon-gamma - immunology Interleukin-10 - biosynthesis Interleukin-10 - genetics Interleukin-10 - immunology Interleukin-12 - genetics Interleukin-12 - immunology Interleukin-12 - metabolism Interleukin-17 - biosynthesis Interleukin-17 - genetics Interleukin-17 - immunology Interleukin-4 - biosynthesis Interleukin-4 - genetics Interleukin-4 - immunology L-Selectin - biosynthesis L-Selectin - genetics L-Selectin - immunology Lymphocyte Activation - physiology Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - genetics Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - immunology Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - metabolism Memory Mice Mice, Knockout Proto-Oncogene Proteins c-maf - genetics Proto-Oncogene Proteins c-maf - immunology Proto-Oncogene Proteins c-maf - metabolism Signal transduction T-Box Domain Proteins - genetics T-Box Domain Proteins - immunology T-Box Domain Proteins - metabolism Th1 Th1 Cells - cytology Th1 Cells - immunology Th1 Cells - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!