Human Rap1 Interacts Directly with Telomeric DNA and Regulates TRF2 Localization at the Telomere

The TRF2-Rap1 complex suppresses non-homologous end joining and interacts with DNAPK-C to prevent end joining. We previously demonstrated that hTRF2 is a double strand telomere binding protein that forms t-loops in vitro and recognizes three- and four-way junctions independent of DNA sequence. How t...

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Veröffentlicht in:	The Journal of biological chemistry 2012-12, Vol.287 (50), p.41583-41594
Hauptverfasser:	Arat, N.Özlem, Griffith, Jack D.
Format:	Artikel
Sprache:	eng
Schlagworte:	DNA - chemistry DNA - genetics DNA - metabolism DNA and Chromosomes DNA Binding Protein DNA Damage DNA Physical Chemistry Electron Microscopy (EM) hRap1 Humans Multiprotein Complexes - chemistry Multiprotein Complexes - genetics Multiprotein Complexes - metabolism Protein Binding - physiology Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - metabolism Telomere - chemistry Telomere - genetics Telomere - metabolism Telomere-Binding Proteins - chemistry Telomere-Binding Proteins - genetics Telomere-Binding Proteins - metabolism Telomeres Telomeric Repeat Binding Protein 2 - chemistry Telomeric Repeat Binding Protein 2 - genetics Telomeric Repeat Binding Protein 2 - metabolism TRF2
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