Polycystin-1 regulates the stability and ubiquitination of transcription factor Jade-1

Autosomal-dominant polycystic kidney disease (ADPKD) and von Hippel-Lindau (VHL) disease lead to large kidney cysts that share pathogenetic features. The polycystin-1 (PC1) and pVHL proteins may therefore participate in the same key signaling pathways. Jade-1 is a pro-apoptotic and growth suppressiv...

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Veröffentlicht in:	Human molecular genetics 2012-12, Vol.21 (26), p.5456-5471
Hauptverfasser:	FOY, Rebecca L, CHITALIA, Vipul C, PIONTEK, Klaus B, GERMINO, Gregory G, ZHOU, Mina I, COHEN, Herbert T, PANCHENKO, Maria V, LILING ZENG, LOPEZ, Delia, LEE, Jean W, RANA, Shaunak V, BOLETTA, Alessandra, FENG QIAN, TSIOKAS, Leonidas
Format:	Artikel
Sprache:	eng
Schlagworte:	Abundance Amino Acid Sequence Apoptosis beta Catenin - genetics beta Catenin - metabolism Biological and medical sciences catenin Cell physiology Cyclin-dependent kinase inhibitor p21 Cyclin-Dependent Kinase Inhibitor p21 - genetics Cyclin-Dependent Kinase Inhibitor p21 - metabolism Cysts Fundamental and applied biological sciences. Psychology Gene Expression Regulation Genetics of eukaryotes. Biological and molecular evolution Half-Life HEK293 Cells Histone acetyltransferase Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Humans Kidney - cytology Kidney - pathology Kidney diseases Molecular and cellular biology Molecular Sequence Data Neoplasia Nuclear Proteins - genetics Nuclear Proteins - metabolism Polycystic kidney Polycystic kidney disease 1 protein Polycystic Kidney, Autosomal Dominant - genetics Polycystic Kidney, Autosomal Dominant - pathology Proteasome Endopeptidase Complex - metabolism pVHL protein Signal transduction Transcription factors Transcription Factors - genetics Transcription Factors - metabolism TRPP Cation Channels - genetics TRPP Cation Channels - metabolism Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism Ubiquitin-protein ligase Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism Ubiquitination Up-Regulation VHL protein von Hippel-Lindau Disease - genetics von Hippel-Lindau Disease - metabolism Von Hippel-Lindau Tumor Suppressor Protein - genetics Von Hippel-Lindau Tumor Suppressor Protein - metabolism Wnt protein Wnt Signaling Pathway
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