Visualizing the Determinants of Viral RNA Recognition by Innate Immune Sensor RIG-I

Retinoic acid inducible gene-I (RIG-I) is a key intracellular immune receptor for pathogenic RNAs, particularly from RNA viruses. Here, we report the crystal structure of human RIG-I bound to a 5′ triphosphorylated RNA hairpin and ADP nucleotide at 2.8 Å resolution. The RNA ligand contains all struc...

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Veröffentlicht in:	Structure 2012-11, Vol.20 (11), p.1983-1988
Hauptverfasser:	Luo, Dahai, Kohlway, Andrew, Vela, Adriana, Pyle, Anna Marie
Format:	Artikel
Sprache:	eng
Schlagworte:	DEAD Box Protein 58 DEAD-box RNA Helicases - immunology Humans Immunity, Innate Models, Molecular Receptors, Immunologic RNA, Viral - metabolism
Online-Zugang:	Volltext
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