Curcumin promotes cardiac repair and ameliorates cardiac dysfunction following myocardial infarction

BACKGROUND AND PURPOSE Curcumin, the natural yellow pigment extracted from the rhizomes of the plant curcuma longa, has been demonstrated to exhibit a variety of potent beneficial effects, acting as an antioxidant, anti‐inflammatory and anti‐fibrotic. In this study we tested the hypothesis that curc...

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Veröffentlicht in:	British journal of pharmacology 2012-12, Vol.167 (7), p.1550-1562
Hauptverfasser:	Wang, Ning‐Ping, Wang, Zhang‐Feng, Tootle, Stephanie, Philip, Tiji, Zhao, Zhi‐Qing
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences cardiac repair Cardiology. Vascular system Cardiotonic Agents - pharmacology Cardiotonic Agents - therapeutic use collagen Collagen - metabolism Coronary heart disease curcumin Curcumin - pharmacology Curcumin - therapeutic use extracellular matrix Heart Male Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase 9 - metabolism Medical sciences Myocardial Infarction - drug therapy Myocardial Infarction - metabolism Myocardial Infarction - pathology Myocardial Infarction - physiopathology Myocardial Reperfusion Injury - drug therapy Myocardial Reperfusion Injury - metabolism Myocardial Reperfusion Injury - pathology Myocardial Reperfusion Injury - physiopathology Myocarditis. Cardiomyopathies Pharmacology. Drug treatments Rats Rats, Sprague-Dawley Research Papers TGFβ/Smad pathway Transforming Growth Factor beta1 - metabolism
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