Investigation on in vitro dissolution rate enhancement of indomethacin by using a novel carrier sucrose fatty acid ester
Background and the purpose of the study The purpose of the present investigation was to characterize and evaluate solid dispersions (SD) of indomethacin by using a novel carrier sucrose fatty acid ester (SFE 1815) to increase its in vitro drug release and further formulating as a tablet. Methods Ind...
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| Veröffentlicht in: | Daru 2012-07, Vol.20 (1), p.4-4, Article 4 |
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| creator | Sunil, Songa Ambedkar Srikanth, Meka Venkata Rao, Nali Sreenivasa Raju, Vengaladasu Murthy, Kolapalli Venkata Ramana |
| description | Background and the purpose of the study
The purpose of the present investigation was to characterize and evaluate solid dispersions (SD) of indomethacin by using a novel carrier sucrose fatty acid ester (SFE 1815) to increase its in vitro drug release and further formulating as a tablet.
Methods
Indomethacin loaded SD were prepared by solvent evaporation and melt granulation technique using SFE 1815 as carrier in 1:0.25, 1:0.5 1:0.75 and 1:1 ratios of drug and carrier. Prepared SD and tablets were subjected to in vitro dissolution studies in 900 mL of pH 7.2 phosphate buffer using apparatus I at 100 rpm. The promising SD were further formulated as tablets using suitable diluent (DCL 21, Avicel PH 102 and pregelatinised starch) to attain the drug release similar to that of SD.. The obtained dissolution data was subjected to kinetic study by fitting the data into various model independent models like zero order, first order, Higuchi, Hixon-Crowell and Peppas equations. Drug and excipient compatibility studies were confirmed by fourier transform infrared spectroscopy, X-ray diffraction, differential scanning calorimetry and scanning electron microscopy.
Results
The in vitro dissolution data exhibited superior release from formulation S
6
with 1:0.5 drug and carrier ratio using solvent evaporation technique than other SDs prepared at different ratio using solvent evaporation and melt granulation technique. The in vitro drug release was also superior to that of the physical mixtures prepared at same ratio and also superior to SD prepared using common carriers like polyvinyl pyrollidone and PEG 4000 by solvent evaporation technique. Tablets (T
8
) prepared with DCL21 as diluent exhibited superior release than the other tablets. The tablet formulation (T
8
) followed first order release with Non-Fickian release.
Conclusion
SFE 1815 a novel third generation carrier can be used for the preparation of SD for the enhancement of
in vitro
drug release of indomethacin an insoluble drug belonging to BCS class II. |
| doi_str_mv | 10.1186/1560-8115-20-4 |
| format | Article |
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The purpose of the present investigation was to characterize and evaluate solid dispersions (SD) of indomethacin by using a novel carrier sucrose fatty acid ester (SFE 1815) to increase its in vitro drug release and further formulating as a tablet.
Methods
Indomethacin loaded SD were prepared by solvent evaporation and melt granulation technique using SFE 1815 as carrier in 1:0.25, 1:0.5 1:0.75 and 1:1 ratios of drug and carrier. Prepared SD and tablets were subjected to in vitro dissolution studies in 900 mL of pH 7.2 phosphate buffer using apparatus I at 100 rpm. The promising SD were further formulated as tablets using suitable diluent (DCL 21, Avicel PH 102 and pregelatinised starch) to attain the drug release similar to that of SD.. The obtained dissolution data was subjected to kinetic study by fitting the data into various model independent models like zero order, first order, Higuchi, Hixon-Crowell and Peppas equations. Drug and excipient compatibility studies were confirmed by fourier transform infrared spectroscopy, X-ray diffraction, differential scanning calorimetry and scanning electron microscopy.
Results
The in vitro dissolution data exhibited superior release from formulation S
6
with 1:0.5 drug and carrier ratio using solvent evaporation technique than other SDs prepared at different ratio using solvent evaporation and melt granulation technique. The in vitro drug release was also superior to that of the physical mixtures prepared at same ratio and also superior to SD prepared using common carriers like polyvinyl pyrollidone and PEG 4000 by solvent evaporation technique. Tablets (T
8
) prepared with DCL21 as diluent exhibited superior release than the other tablets. The tablet formulation (T
8
) followed first order release with Non-Fickian release.
Conclusion
SFE 1815 a novel third generation carrier can be used for the preparation of SD for the enhancement of
in vitro
drug release of indomethacin an insoluble drug belonging to BCS class II.</description><identifier>ISSN: 1560-8115</identifier><identifier>ISSN: 2008-2231</identifier><identifier>EISSN: 2008-2231</identifier><identifier>DOI: 10.1186/1560-8115-20-4</identifier><identifier>PMID: 23226721</identifier><language>eng</language><publisher>London: BioMed Central</publisher><subject>Analysis ; Biomedical and Life Sciences ; Biomedicine ; Communications industry ; Fatty acids ; Health aspects ; Indomethacin ; Investigations ; Medicinal Chemistry ; Pharmaceutical Sciences/Technology ; Pharmacology/Toxicology ; Phosphates ; Physiological aspects ; Research Article ; Sucrose ; Telecommunications services industry</subject><ispartof>Daru, 2012-07, Vol.20 (1), p.4-4, Article 4</ispartof><rights>Sunil et al.; licensee BioMed Central Ltd. 2012</rights><rights>COPYRIGHT 2012 BioMed Central Ltd.</rights><rights>Copyright ©2012 Sunil et al.; licensee BioMed Central Ltd. 2012 Sunil et al.; licensee BioMed Central Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b586t-d7cfb0ef8f302b8d9913e71daa7b5fc8ee621fc8887b225c14cccf036a62db213</citedby><cites>FETCH-LOGICAL-b586t-d7cfb0ef8f302b8d9913e71daa7b5fc8ee621fc8887b225c14cccf036a62db213</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514539/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514539/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,41464,42533,51294,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23226721$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sunil, Songa Ambedkar</creatorcontrib><creatorcontrib>Srikanth, Meka Venkata</creatorcontrib><creatorcontrib>Rao, Nali Sreenivasa</creatorcontrib><creatorcontrib>Raju, Vengaladasu</creatorcontrib><creatorcontrib>Murthy, Kolapalli Venkata Ramana</creatorcontrib><title>Investigation on in vitro dissolution rate enhancement of indomethacin by using a novel carrier sucrose fatty acid ester</title><title>Daru</title><addtitle>DARU J Pharm Sci</addtitle><addtitle>Daru</addtitle><description>Background and the purpose of the study
The purpose of the present investigation was to characterize and evaluate solid dispersions (SD) of indomethacin by using a novel carrier sucrose fatty acid ester (SFE 1815) to increase its in vitro drug release and further formulating as a tablet.
Methods
Indomethacin loaded SD were prepared by solvent evaporation and melt granulation technique using SFE 1815 as carrier in 1:0.25, 1:0.5 1:0.75 and 1:1 ratios of drug and carrier. Prepared SD and tablets were subjected to in vitro dissolution studies in 900 mL of pH 7.2 phosphate buffer using apparatus I at 100 rpm. The promising SD were further formulated as tablets using suitable diluent (DCL 21, Avicel PH 102 and pregelatinised starch) to attain the drug release similar to that of SD.. The obtained dissolution data was subjected to kinetic study by fitting the data into various model independent models like zero order, first order, Higuchi, Hixon-Crowell and Peppas equations. Drug and excipient compatibility studies were confirmed by fourier transform infrared spectroscopy, X-ray diffraction, differential scanning calorimetry and scanning electron microscopy.
Results
The in vitro dissolution data exhibited superior release from formulation S
6
with 1:0.5 drug and carrier ratio using solvent evaporation technique than other SDs prepared at different ratio using solvent evaporation and melt granulation technique. The in vitro drug release was also superior to that of the physical mixtures prepared at same ratio and also superior to SD prepared using common carriers like polyvinyl pyrollidone and PEG 4000 by solvent evaporation technique. Tablets (T
8
) prepared with DCL21 as diluent exhibited superior release than the other tablets. The tablet formulation (T
8
) followed first order release with Non-Fickian release.
Conclusion
SFE 1815 a novel third generation carrier can be used for the preparation of SD for the enhancement of
in vitro
drug release of indomethacin an insoluble drug belonging to BCS class II.</description><subject>Analysis</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Communications industry</subject><subject>Fatty acids</subject><subject>Health aspects</subject><subject>Indomethacin</subject><subject>Investigations</subject><subject>Medicinal Chemistry</subject><subject>Pharmaceutical Sciences/Technology</subject><subject>Pharmacology/Toxicology</subject><subject>Phosphates</subject><subject>Physiological aspects</subject><subject>Research Article</subject><subject>Sucrose</subject><subject>Telecommunications services industry</subject><issn>1560-8115</issn><issn>2008-2231</issn><issn>2008-2231</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><recordid>eNp1kk1r3DAQhk1pabZprz0WQaHk4kQflq29FJbQtIFAL-1ZyPLIVrClVJKX7L-v3E2WLE2QQDDzzKv5KoqPBJ8TIuoLwmtcCkJ4SXFZvSpWFGNRUsrI62J1cJ4U72K8xZiJqqZvixPKKK0bSlbF_bXbQky2V8l6h_K1Dm1tCh51NkY_zv_sQSVA4AblNEzgEvImg52fIA1K55B2h-ZoXY8Ucn4LI9IqBAsBxVkHHwEZldIOZbZD-T8I74s3Ro0RPjy8p8Xvq2-_Ln-UNz-_X19ubsqWizqVXaNNi8EIwzBtRbdeEwYN6ZRqWm60AKgpya8QTUsp16TSWhvMalXTrqWEnRZf97p3cztBp3PyQY3yLthJhZ30yspjj7OD7P1WMk4qztZZYLMXaK1_QeDYo_0kl87LpfOSYllljbOHJIL_M-f65WSjhnFUDvwcJaGswWvcUJ7Rz3u0VyNI64zPonrB5YazCvOqXteZOn-GyqeDyWrvwNhsPwr48iRgADWm4XG68VnlZWwxgDlUSrBcVu7_2j49bfABf9yxDFzsgZhdrocgb_0cXB76S5J_AT0X4pI</recordid><startdate>20120719</startdate><enddate>20120719</enddate><creator>Sunil, Songa Ambedkar</creator><creator>Srikanth, Meka Venkata</creator><creator>Rao, Nali Sreenivasa</creator><creator>Raju, Vengaladasu</creator><creator>Murthy, Kolapalli Venkata Ramana</creator><general>BioMed Central</general><general>BioMed Central Ltd</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20120719</creationdate><title>Investigation on in vitro dissolution rate enhancement of indomethacin by using a novel carrier sucrose fatty acid ester</title><author>Sunil, Songa Ambedkar ; Srikanth, Meka Venkata ; Rao, Nali Sreenivasa ; Raju, Vengaladasu ; Murthy, Kolapalli Venkata Ramana</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b586t-d7cfb0ef8f302b8d9913e71daa7b5fc8ee621fc8887b225c14cccf036a62db213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Analysis</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Communications industry</topic><topic>Fatty acids</topic><topic>Health aspects</topic><topic>Indomethacin</topic><topic>Investigations</topic><topic>Medicinal Chemistry</topic><topic>Pharmaceutical Sciences/Technology</topic><topic>Pharmacology/Toxicology</topic><topic>Phosphates</topic><topic>Physiological aspects</topic><topic>Research Article</topic><topic>Sucrose</topic><topic>Telecommunications services industry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sunil, Songa Ambedkar</creatorcontrib><creatorcontrib>Srikanth, Meka Venkata</creatorcontrib><creatorcontrib>Rao, Nali Sreenivasa</creatorcontrib><creatorcontrib>Raju, Vengaladasu</creatorcontrib><creatorcontrib>Murthy, Kolapalli Venkata Ramana</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Daru</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sunil, Songa Ambedkar</au><au>Srikanth, Meka Venkata</au><au>Rao, Nali Sreenivasa</au><au>Raju, Vengaladasu</au><au>Murthy, Kolapalli Venkata Ramana</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Investigation on in vitro dissolution rate enhancement of indomethacin by using a novel carrier sucrose fatty acid ester</atitle><jtitle>Daru</jtitle><stitle>DARU J Pharm Sci</stitle><addtitle>Daru</addtitle><date>2012-07-19</date><risdate>2012</risdate><volume>20</volume><issue>1</issue><spage>4</spage><epage>4</epage><pages>4-4</pages><artnum>4</artnum><issn>1560-8115</issn><issn>2008-2231</issn><eissn>2008-2231</eissn><abstract>Background and the purpose of the study
The purpose of the present investigation was to characterize and evaluate solid dispersions (SD) of indomethacin by using a novel carrier sucrose fatty acid ester (SFE 1815) to increase its in vitro drug release and further formulating as a tablet.
Methods
Indomethacin loaded SD were prepared by solvent evaporation and melt granulation technique using SFE 1815 as carrier in 1:0.25, 1:0.5 1:0.75 and 1:1 ratios of drug and carrier. Prepared SD and tablets were subjected to in vitro dissolution studies in 900 mL of pH 7.2 phosphate buffer using apparatus I at 100 rpm. The promising SD were further formulated as tablets using suitable diluent (DCL 21, Avicel PH 102 and pregelatinised starch) to attain the drug release similar to that of SD.. The obtained dissolution data was subjected to kinetic study by fitting the data into various model independent models like zero order, first order, Higuchi, Hixon-Crowell and Peppas equations. Drug and excipient compatibility studies were confirmed by fourier transform infrared spectroscopy, X-ray diffraction, differential scanning calorimetry and scanning electron microscopy.
Results
The in vitro dissolution data exhibited superior release from formulation S
6
with 1:0.5 drug and carrier ratio using solvent evaporation technique than other SDs prepared at different ratio using solvent evaporation and melt granulation technique. The in vitro drug release was also superior to that of the physical mixtures prepared at same ratio and also superior to SD prepared using common carriers like polyvinyl pyrollidone and PEG 4000 by solvent evaporation technique. Tablets (T
8
) prepared with DCL21 as diluent exhibited superior release than the other tablets. The tablet formulation (T
8
) followed first order release with Non-Fickian release.
Conclusion
SFE 1815 a novel third generation carrier can be used for the preparation of SD for the enhancement of
in vitro
drug release of indomethacin an insoluble drug belonging to BCS class II.</abstract><cop>London</cop><pub>BioMed Central</pub><pmid>23226721</pmid><doi>10.1186/1560-8115-20-4</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1560-8115 |
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| source | Springer Nature - Complete Springer Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Analysis Biomedical and Life Sciences Biomedicine Communications industry Fatty acids Health aspects Indomethacin Investigations Medicinal Chemistry Pharmaceutical Sciences/Technology Pharmacology/Toxicology Phosphates Physiological aspects Research Article Sucrose Telecommunications services industry |
| title | Investigation on in vitro dissolution rate enhancement of indomethacin by using a novel carrier sucrose fatty acid ester |
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