Beta‐Adrenergic Receptor Polymorphisms and Cardiac Graft Function in Potential Organ Donors
Prior studies have demonstrated associations between beta‐adrenergic receptor (βAR) polymorphisms and left ventricular dysfunction—an important cause of allograft nonutilization for transplantation. We hypothesized that βAR polymorphisms predispose donor hearts to LV dysfunction after brain death. A...
Gespeichert in:
| Veröffentlicht in: | American journal of transplantation 2012-12, Vol.12 (12), p.3377-3386 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 3386 |
|---|---|
| container_issue | 12 |
| container_start_page | 3377 |
| container_title | American journal of transplantation |
| container_volume | 12 |
| creator | Khush, K. K. Pawlikowska, L. Menza, R. L. Goldstein, B. A. Hayden, V. Nguyen, J. Kim, H. Poon, A. Sapru, A. Matthay, M. A. Kwok, P. Y. Young, W. L. Baxter‐Lowe, L. A. Zaroff, J. G. |
| description | Prior studies have demonstrated associations between beta‐adrenergic receptor (βAR) polymorphisms and left ventricular dysfunction—an important cause of allograft nonutilization for transplantation. We hypothesized that βAR polymorphisms predispose donor hearts to LV dysfunction after brain death. A total of 1043 organ donors managed from 2001–2006 were initially studied. The following βAR single nucleotide polymorphisms were genotyped: β1AR 1165C/G (Arg389Gly), β1AR 145A/G (Ser49Gly), β2AR 46G/A (Gly16Arg) and β2AR 79C/G (Gln27Glu). In multivariable regression analyses, the β2AR46 SNP was significantly associated with LV systolic dysfunction, with each minor allele additively decreasing the odds for LV ejection fraction 10 μg/kg/min of dopamine compared to those with the CC and GG genotypes. However, no significant associations were found between βAR SNPs and cardiac dysfunction in 364 donors managed from 2007–2008, perhaps due to changes in donor management, lack of power in this validation cohort, or the absence of a true association. βAR polymorphisms may be associated with cardiac dysfunction after brain death, but these relationships require further study in independent donor cohorts.
A genetics study performed in 1,400 potential organ donors reveals possible associations between beta‐adrenergic receptor polymorphisms and cardiac function after brain death. See editorial by Salomon on page 3173. |
| doi_str_mv | 10.1111/j.1600-6143.2012.04266.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3513582</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1273623785</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5376-1f6a50eb215c7013b84d50cfc9614e7d0ab9a3237b7798bfe48ea5a025a4bd993</originalsourceid><addsrcrecordid>eNqNkc-O0zAQxi0EYpfCKyBfkLg0-E8cOweQSmEX0EqL0HJE1sRxuq4Su2unsL3xCDwjT4JDS4ET-OKR5jej75sPIUxJQfN7ti5oRci8oiUvGKGsICWrquL2Djo9Nu4eay5O0IOU1oRQyRS7j04Yq-uyEuUp-vTSjvD967dFG623ceUM_mCN3Ywh4veh3w0hbq5dGhIG3-IlxNaBwecRuhGfbb0ZXfDY-cyO1o8OenwZV-Dxq-BDTA_RvQ76ZB8d_hn6ePb6avlmfnF5_na5uJgbwWU1p10FgtiGUWEkobxRZSuI6UydjVjZEmhq4IzLRspaNZ0tlQUBhAkom7au-Qy92O_dbJvBtiZLidDrTXQDxJ0O4PTfHe-u9Sp81lzk6yiWFzw9LIjhZmvTqAeXjO178DZsk6ZSCcZLyci_USZ5lbUqkVG1R00MKUXbHRVRoqcg9VpPGekpLz0FqX8GqW_z6OM_HR0HfyWXgScHAJKBvovgjUu_uUoqLrO7GXq-57643u7-W4BevLuaKv4DFY267g</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1273623785</pqid></control><display><type>article</type><title>Beta‐Adrenergic Receptor Polymorphisms and Cardiac Graft Function in Potential Organ Donors</title><source>MEDLINE</source><source>Wiley Online Library Journals</source><source>Alma/SFX Local Collection</source><source>EZB Electronic Journals Library</source><creator>Khush, K. K. ; Pawlikowska, L. ; Menza, R. L. ; Goldstein, B. A. ; Hayden, V. ; Nguyen, J. ; Kim, H. ; Poon, A. ; Sapru, A. ; Matthay, M. A. ; Kwok, P. Y. ; Young, W. L. ; Baxter‐Lowe, L. A. ; Zaroff, J. G.</creator><creatorcontrib>Khush, K. K. ; Pawlikowska, L. ; Menza, R. L. ; Goldstein, B. A. ; Hayden, V. ; Nguyen, J. ; Kim, H. ; Poon, A. ; Sapru, A. ; Matthay, M. A. ; Kwok, P. Y. ; Young, W. L. ; Baxter‐Lowe, L. A. ; Zaroff, J. G.</creatorcontrib><description>Prior studies have demonstrated associations between beta‐adrenergic receptor (βAR) polymorphisms and left ventricular dysfunction—an important cause of allograft nonutilization for transplantation. We hypothesized that βAR polymorphisms predispose donor hearts to LV dysfunction after brain death. A total of 1043 organ donors managed from 2001–2006 were initially studied. The following βAR single nucleotide polymorphisms were genotyped: β1AR 1165C/G (Arg389Gly), β1AR 145A/G (Ser49Gly), β2AR 46G/A (Gly16Arg) and β2AR 79C/G (Gln27Glu). In multivariable regression analyses, the β2AR46 SNP was significantly associated with LV systolic dysfunction, with each minor allele additively decreasing the odds for LV ejection fraction <50%. The β1AR1165 and β2AR46 SNPs were associated with higher dopamine requirement during the donor management period: donors with the GG and AA genotypes had ORs of 2.64 (95% CI 1.52–4.57) and 2.70 (1.07–2.74) respectively for requiring >10 μg/kg/min of dopamine compared to those with the CC and GG genotypes. However, no significant associations were found between βAR SNPs and cardiac dysfunction in 364 donors managed from 2007–2008, perhaps due to changes in donor management, lack of power in this validation cohort, or the absence of a true association. βAR polymorphisms may be associated with cardiac dysfunction after brain death, but these relationships require further study in independent donor cohorts.
A genetics study performed in 1,400 potential organ donors reveals possible associations between beta‐adrenergic receptor polymorphisms and cardiac function after brain death. See editorial by Salomon on page 3173.</description><identifier>ISSN: 1600-6135</identifier><identifier>EISSN: 1600-6143</identifier><identifier>DOI: 10.1111/j.1600-6143.2012.04266.x</identifier><identifier>PMID: 22994654</identifier><language>eng</language><publisher>Malden, USA: Blackwell Publishing Inc</publisher><subject>Adult ; Allograft function ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Brain Death ; cardiac allograft ; cardiac transplant ; Clinical death. Palliative care. Organ gift and preservation ; cohort study ; donor evaluation ; donor management ; donor outcomes ; Female ; genetic polymorphism ; genotyping ; Graft Survival - physiology ; Humans ; Male ; Medical sciences ; Middle Aged ; Miscellaneous ; Polymorphism, Genetic - genetics ; Prognosis ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Receptors, Adrenergic, beta-1 - genetics ; Receptors, Adrenergic, beta-2 - genetics ; Retrospective Studies ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Tissue Donors ; Validation Studies as Topic ; Ventricular Dysfunction, Left - genetics</subject><ispartof>American journal of transplantation, 2012-12, Vol.12 (12), p.3377-3386</ispartof><rights>Copyright 2012 The American Society of Transplantation and the American Society of Transplant Surgeons</rights><rights>2014 INIST-CNRS</rights><rights>Copyright 2012 The American Society of Transplantation and the American Society of Transplant Surgeons.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5376-1f6a50eb215c7013b84d50cfc9614e7d0ab9a3237b7798bfe48ea5a025a4bd993</citedby><cites>FETCH-LOGICAL-c5376-1f6a50eb215c7013b84d50cfc9614e7d0ab9a3237b7798bfe48ea5a025a4bd993</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1600-6143.2012.04266.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1600-6143.2012.04266.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26783751$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22994654$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Khush, K. K.</creatorcontrib><creatorcontrib>Pawlikowska, L.</creatorcontrib><creatorcontrib>Menza, R. L.</creatorcontrib><creatorcontrib>Goldstein, B. A.</creatorcontrib><creatorcontrib>Hayden, V.</creatorcontrib><creatorcontrib>Nguyen, J.</creatorcontrib><creatorcontrib>Kim, H.</creatorcontrib><creatorcontrib>Poon, A.</creatorcontrib><creatorcontrib>Sapru, A.</creatorcontrib><creatorcontrib>Matthay, M. A.</creatorcontrib><creatorcontrib>Kwok, P. Y.</creatorcontrib><creatorcontrib>Young, W. L.</creatorcontrib><creatorcontrib>Baxter‐Lowe, L. A.</creatorcontrib><creatorcontrib>Zaroff, J. G.</creatorcontrib><title>Beta‐Adrenergic Receptor Polymorphisms and Cardiac Graft Function in Potential Organ Donors</title><title>American journal of transplantation</title><addtitle>Am J Transplant</addtitle><description>Prior studies have demonstrated associations between beta‐adrenergic receptor (βAR) polymorphisms and left ventricular dysfunction—an important cause of allograft nonutilization for transplantation. We hypothesized that βAR polymorphisms predispose donor hearts to LV dysfunction after brain death. A total of 1043 organ donors managed from 2001–2006 were initially studied. The following βAR single nucleotide polymorphisms were genotyped: β1AR 1165C/G (Arg389Gly), β1AR 145A/G (Ser49Gly), β2AR 46G/A (Gly16Arg) and β2AR 79C/G (Gln27Glu). In multivariable regression analyses, the β2AR46 SNP was significantly associated with LV systolic dysfunction, with each minor allele additively decreasing the odds for LV ejection fraction <50%. The β1AR1165 and β2AR46 SNPs were associated with higher dopamine requirement during the donor management period: donors with the GG and AA genotypes had ORs of 2.64 (95% CI 1.52–4.57) and 2.70 (1.07–2.74) respectively for requiring >10 μg/kg/min of dopamine compared to those with the CC and GG genotypes. However, no significant associations were found between βAR SNPs and cardiac dysfunction in 364 donors managed from 2007–2008, perhaps due to changes in donor management, lack of power in this validation cohort, or the absence of a true association. βAR polymorphisms may be associated with cardiac dysfunction after brain death, but these relationships require further study in independent donor cohorts.
A genetics study performed in 1,400 potential organ donors reveals possible associations between beta‐adrenergic receptor polymorphisms and cardiac function after brain death. See editorial by Salomon on page 3173.</description><subject>Adult</subject><subject>Allograft function</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Brain Death</subject><subject>cardiac allograft</subject><subject>cardiac transplant</subject><subject>Clinical death. Palliative care. Organ gift and preservation</subject><subject>cohort study</subject><subject>donor evaluation</subject><subject>donor management</subject><subject>donor outcomes</subject><subject>Female</subject><subject>genetic polymorphism</subject><subject>genotyping</subject><subject>Graft Survival - physiology</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Polymorphism, Genetic - genetics</subject><subject>Prognosis</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Receptors, Adrenergic, beta-1 - genetics</subject><subject>Receptors, Adrenergic, beta-2 - genetics</subject><subject>Retrospective Studies</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Tissue Donors</subject><subject>Validation Studies as Topic</subject><subject>Ventricular Dysfunction, Left - genetics</subject><issn>1600-6135</issn><issn>1600-6143</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc-O0zAQxi0EYpfCKyBfkLg0-E8cOweQSmEX0EqL0HJE1sRxuq4Su2unsL3xCDwjT4JDS4ET-OKR5jej75sPIUxJQfN7ti5oRci8oiUvGKGsICWrquL2Djo9Nu4eay5O0IOU1oRQyRS7j04Yq-uyEuUp-vTSjvD967dFG623ceUM_mCN3Ywh4veh3w0hbq5dGhIG3-IlxNaBwecRuhGfbb0ZXfDY-cyO1o8OenwZV-Dxq-BDTA_RvQ76ZB8d_hn6ePb6avlmfnF5_na5uJgbwWU1p10FgtiGUWEkobxRZSuI6UydjVjZEmhq4IzLRspaNZ0tlQUBhAkom7au-Qy92O_dbJvBtiZLidDrTXQDxJ0O4PTfHe-u9Sp81lzk6yiWFzw9LIjhZmvTqAeXjO178DZsk6ZSCcZLyci_USZ5lbUqkVG1R00MKUXbHRVRoqcg9VpPGekpLz0FqX8GqW_z6OM_HR0HfyWXgScHAJKBvovgjUu_uUoqLrO7GXq-57643u7-W4BevLuaKv4DFY267g</recordid><startdate>201212</startdate><enddate>201212</enddate><creator>Khush, K. K.</creator><creator>Pawlikowska, L.</creator><creator>Menza, R. L.</creator><creator>Goldstein, B. A.</creator><creator>Hayden, V.</creator><creator>Nguyen, J.</creator><creator>Kim, H.</creator><creator>Poon, A.</creator><creator>Sapru, A.</creator><creator>Matthay, M. A.</creator><creator>Kwok, P. Y.</creator><creator>Young, W. L.</creator><creator>Baxter‐Lowe, L. A.</creator><creator>Zaroff, J. G.</creator><general>Blackwell Publishing Inc</general><general>Wiley</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope><scope>5PM</scope></search><sort><creationdate>201212</creationdate><title>Beta‐Adrenergic Receptor Polymorphisms and Cardiac Graft Function in Potential Organ Donors</title><author>Khush, K. K. ; Pawlikowska, L. ; Menza, R. L. ; Goldstein, B. A. ; Hayden, V. ; Nguyen, J. ; Kim, H. ; Poon, A. ; Sapru, A. ; Matthay, M. A. ; Kwok, P. Y. ; Young, W. L. ; Baxter‐Lowe, L. A. ; Zaroff, J. G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5376-1f6a50eb215c7013b84d50cfc9614e7d0ab9a3237b7798bfe48ea5a025a4bd993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Allograft function</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Brain Death</topic><topic>cardiac allograft</topic><topic>cardiac transplant</topic><topic>Clinical death. Palliative care. Organ gift and preservation</topic><topic>cohort study</topic><topic>donor evaluation</topic><topic>donor management</topic><topic>donor outcomes</topic><topic>Female</topic><topic>genetic polymorphism</topic><topic>genotyping</topic><topic>Graft Survival - physiology</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Polymorphism, Genetic - genetics</topic><topic>Prognosis</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>Receptors, Adrenergic, beta-1 - genetics</topic><topic>Receptors, Adrenergic, beta-2 - genetics</topic><topic>Retrospective Studies</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Tissue Donors</topic><topic>Validation Studies as Topic</topic><topic>Ventricular Dysfunction, Left - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Khush, K. K.</creatorcontrib><creatorcontrib>Pawlikowska, L.</creatorcontrib><creatorcontrib>Menza, R. L.</creatorcontrib><creatorcontrib>Goldstein, B. A.</creatorcontrib><creatorcontrib>Hayden, V.</creatorcontrib><creatorcontrib>Nguyen, J.</creatorcontrib><creatorcontrib>Kim, H.</creatorcontrib><creatorcontrib>Poon, A.</creatorcontrib><creatorcontrib>Sapru, A.</creatorcontrib><creatorcontrib>Matthay, M. A.</creatorcontrib><creatorcontrib>Kwok, P. Y.</creatorcontrib><creatorcontrib>Young, W. L.</creatorcontrib><creatorcontrib>Baxter‐Lowe, L. A.</creatorcontrib><creatorcontrib>Zaroff, J. G.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>American journal of transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Khush, K. K.</au><au>Pawlikowska, L.</au><au>Menza, R. L.</au><au>Goldstein, B. A.</au><au>Hayden, V.</au><au>Nguyen, J.</au><au>Kim, H.</au><au>Poon, A.</au><au>Sapru, A.</au><au>Matthay, M. A.</au><au>Kwok, P. Y.</au><au>Young, W. L.</au><au>Baxter‐Lowe, L. A.</au><au>Zaroff, J. G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Beta‐Adrenergic Receptor Polymorphisms and Cardiac Graft Function in Potential Organ Donors</atitle><jtitle>American journal of transplantation</jtitle><addtitle>Am J Transplant</addtitle><date>2012-12</date><risdate>2012</risdate><volume>12</volume><issue>12</issue><spage>3377</spage><epage>3386</epage><pages>3377-3386</pages><issn>1600-6135</issn><eissn>1600-6143</eissn><abstract>Prior studies have demonstrated associations between beta‐adrenergic receptor (βAR) polymorphisms and left ventricular dysfunction—an important cause of allograft nonutilization for transplantation. We hypothesized that βAR polymorphisms predispose donor hearts to LV dysfunction after brain death. A total of 1043 organ donors managed from 2001–2006 were initially studied. The following βAR single nucleotide polymorphisms were genotyped: β1AR 1165C/G (Arg389Gly), β1AR 145A/G (Ser49Gly), β2AR 46G/A (Gly16Arg) and β2AR 79C/G (Gln27Glu). In multivariable regression analyses, the β2AR46 SNP was significantly associated with LV systolic dysfunction, with each minor allele additively decreasing the odds for LV ejection fraction <50%. The β1AR1165 and β2AR46 SNPs were associated with higher dopamine requirement during the donor management period: donors with the GG and AA genotypes had ORs of 2.64 (95% CI 1.52–4.57) and 2.70 (1.07–2.74) respectively for requiring >10 μg/kg/min of dopamine compared to those with the CC and GG genotypes. However, no significant associations were found between βAR SNPs and cardiac dysfunction in 364 donors managed from 2007–2008, perhaps due to changes in donor management, lack of power in this validation cohort, or the absence of a true association. βAR polymorphisms may be associated with cardiac dysfunction after brain death, but these relationships require further study in independent donor cohorts.
A genetics study performed in 1,400 potential organ donors reveals possible associations between beta‐adrenergic receptor polymorphisms and cardiac function after brain death. See editorial by Salomon on page 3173.</abstract><cop>Malden, USA</cop><pub>Blackwell Publishing Inc</pub><pmid>22994654</pmid><doi>10.1111/j.1600-6143.2012.04266.x</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1600-6135 |
| ispartof | American journal of transplantation, 2012-12, Vol.12 (12), p.3377-3386 |
| issn | 1600-6135 1600-6143 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3513582 |
| source | MEDLINE; Wiley Online Library Journals; Alma/SFX Local Collection; EZB Electronic Journals Library |
| subjects | Adult Allograft function Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Brain Death cardiac allograft cardiac transplant Clinical death. Palliative care. Organ gift and preservation cohort study donor evaluation donor management donor outcomes Female genetic polymorphism genotyping Graft Survival - physiology Humans Male Medical sciences Middle Aged Miscellaneous Polymorphism, Genetic - genetics Prognosis Public health. Hygiene Public health. Hygiene-occupational medicine Receptors, Adrenergic, beta-1 - genetics Receptors, Adrenergic, beta-2 - genetics Retrospective Studies Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Tissue Donors Validation Studies as Topic Ventricular Dysfunction, Left - genetics |
| title | Beta‐Adrenergic Receptor Polymorphisms and Cardiac Graft Function in Potential Organ Donors |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-12T08%3A10%3A29IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Beta%E2%80%90Adrenergic%20Receptor%20Polymorphisms%20and%20Cardiac%20Graft%20Function%20in%20Potential%20Organ%20Donors&rft.jtitle=American%20journal%20of%20transplantation&rft.au=Khush,%20K.%20K.&rft.date=2012-12&rft.volume=12&rft.issue=12&rft.spage=3377&rft.epage=3386&rft.pages=3377-3386&rft.issn=1600-6135&rft.eissn=1600-6143&rft_id=info:doi/10.1111/j.1600-6143.2012.04266.x&rft_dat=%3Cproquest_pubme%3E1273623785%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1273623785&rft_id=info:pmid/22994654&rfr_iscdi=true |