The impact of HAART on cardiomyopathy among children and adolescents perinatally infected with HIV-1

Previous studies of cardiomyopathy among children perinatally infected with HIV were conducted before the routine use of HAART. Nucleoside analogs [nucleoside reverse transcriptase inhibitors (NRTIs)], the backbone of HAART, have been associated with mitochondrial toxicity, which can lead to cardiom...

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Veröffentlicht in:	AIDS (London) 2012-10, Vol.26 (16), p.2027-2037
Hauptverfasser:	PATEL, Kunjal, VAN DYKE, Russell B, MITTLEMAN, Murray A, COLAN, Steven D, OLESKE, James M, SEAGE, George R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescence Adolescent Age Anti-HIV Agents - adverse effects Antibiotics. Antiinfectious agents. Antiparasitic agents Antiretroviral Therapy, Highly Active - adverse effects Antiviral agents Biological and medical sciences Cardiology. Vascular system Cardiomyopathies - chemically induced Cardiomyopathies - epidemiology Cardiomyopathies - prevention & control Cardiomyopathy Cardiotonic Agents - administration & dosage CD4 antigen CD4 Lymphocyte Count Child Child, Preschool Children Cohort Studies digoxin Digoxin - administration & dosage Female Follow-Up Studies Geriatrics Heart highly active antiretroviral therapy HIV Seropositivity - complications HIV Seropositivity - drug therapy HIV Seropositivity - epidemiology Human immunodeficiency virus Human immunodeficiency virus 1 Human viral diseases Humans Infant Infectious Disease Transmission, Vertical - statistics & numerical data Infectious diseases Male Medical sciences Mitochondria Mortality Myocarditis. Cardiomyopathies nucleoside analogs nucleoside reverse transcriptase inhibitors Pharmacology. Drug treatments Pregnancy Prenatal Exposure Delayed Effects - drug therapy Prenatal Exposure Delayed Effects - epidemiology Proportional Hazards Models Prospective Studies Toxicity Treatment Outcome United States - epidemiology Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Zalcitabine Zalcitabine - adverse effects Zidovudine Zidovudine - adverse effects
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