A Blueprint for HIV Vaccine Discovery
Despite numerous attempts over many years to develop an HIV vaccine based on classical strategies, none has convincingly succeeded to date. A number of approaches are being pursued in the field, including building upon possible efficacy indicated by the recent RV144 clinical trial, which combined tw...
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| Veröffentlicht in: | Cell host & microbe 2012-10, Vol.12 (4), p.396-407 |
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| creator | Burton, Dennis R Ahmed, Rafi Barouch, Dan H Butera, Salvatore T Crotty, Shane Godzik, Adam Kaufmann, Daniel E McElrath, M Juliana Nussenzweig, Michel C Pulendran, Bali Scanlan, Chris N Schief, William R Silvestri, Guido Streeck, Hendrik Walker, Bruce D Walker, Laura M Ward, Andrew B Wilson, Ian A Wyatt, Richard |
| description | Despite numerous attempts over many years to develop an HIV vaccine based on classical strategies, none has convincingly succeeded to date. A number of approaches are being pursued in the field, including building upon possible efficacy indicated by the recent RV144 clinical trial, which combined two HIV vaccines. Here, we argue for an approach based, in part, on understanding the HIV envelope spike and its interaction with broadly neutralizing antibodies (bnAbs) at the molecular level and using this understanding to design immunogens as possible vaccines. BnAbs can protect against virus challenge in animal models, and many such antibodies have been isolated recently. We further propose that studies focused on how best to provide T cell help to B cells that produce bnAbs are crucial for optimal immunization strategies. The synthesis of rational immunogen design and immunization strategies, together with iterative improvements, offers great promise for advancing toward an HIV vaccine. |
| doi_str_mv | 10.1016/j.chom.2012.09.008 |
| format | Article |
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A number of approaches are being pursued in the field, including building upon possible efficacy indicated by the recent RV144 clinical trial, which combined two HIV vaccines. Here, we argue for an approach based, in part, on understanding the HIV envelope spike and its interaction with broadly neutralizing antibodies (bnAbs) at the molecular level and using this understanding to design immunogens as possible vaccines. BnAbs can protect against virus challenge in animal models, and many such antibodies have been isolated recently. We further propose that studies focused on how best to provide T cell help to B cells that produce bnAbs are crucial for optimal immunization strategies. The synthesis of rational immunogen design and immunization strategies, together with iterative improvements, offers great promise for advancing toward an HIV vaccine.</description><identifier>ISSN: 1931-3128</identifier><identifier>EISSN: 1934-6069</identifier><identifier>DOI: 10.1016/j.chom.2012.09.008</identifier><identifier>PMID: 23084910</identifier><language>eng</language><publisher>United States</publisher><subject>AIDS Vaccines - immunology ; Allergy and Immunology - trends ; Animals ; Antibodies, Neutralizing - blood ; Antibodies, Neutralizing - immunology ; Antibodies, Viral - blood ; Antibodies, Viral - immunology ; B-Lymphocytes - immunology ; Clinical Trials as Topic ; Disease Models, Animal ; HIV Infections - prevention & control ; Humans ; T-Lymphocytes - immunology</subject><ispartof>Cell host & microbe, 2012-10, Vol.12 (4), p.396-407</ispartof><rights>Copyright © 2012 Elsevier Inc. All rights reserved.</rights><rights>2012 Elsevier Inc. All rights reserved. 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c402t-f9a45c2e1317a25f03dd06bfacdc14d4192dd4e75b5a921deb630e25e3b2d5a43</citedby><cites>FETCH-LOGICAL-c402t-f9a45c2e1317a25f03dd06bfacdc14d4192dd4e75b5a921deb630e25e3b2d5a43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23084910$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Burton, Dennis R</creatorcontrib><creatorcontrib>Ahmed, Rafi</creatorcontrib><creatorcontrib>Barouch, Dan H</creatorcontrib><creatorcontrib>Butera, Salvatore T</creatorcontrib><creatorcontrib>Crotty, Shane</creatorcontrib><creatorcontrib>Godzik, Adam</creatorcontrib><creatorcontrib>Kaufmann, Daniel E</creatorcontrib><creatorcontrib>McElrath, M Juliana</creatorcontrib><creatorcontrib>Nussenzweig, Michel C</creatorcontrib><creatorcontrib>Pulendran, Bali</creatorcontrib><creatorcontrib>Scanlan, Chris N</creatorcontrib><creatorcontrib>Schief, William R</creatorcontrib><creatorcontrib>Silvestri, Guido</creatorcontrib><creatorcontrib>Streeck, Hendrik</creatorcontrib><creatorcontrib>Walker, Bruce D</creatorcontrib><creatorcontrib>Walker, Laura M</creatorcontrib><creatorcontrib>Ward, Andrew B</creatorcontrib><creatorcontrib>Wilson, Ian A</creatorcontrib><creatorcontrib>Wyatt, Richard</creatorcontrib><title>A Blueprint for HIV Vaccine Discovery</title><title>Cell host & microbe</title><addtitle>Cell Host Microbe</addtitle><description>Despite numerous attempts over many years to develop an HIV vaccine based on classical strategies, none has convincingly succeeded to date. A number of approaches are being pursued in the field, including building upon possible efficacy indicated by the recent RV144 clinical trial, which combined two HIV vaccines. Here, we argue for an approach based, in part, on understanding the HIV envelope spike and its interaction with broadly neutralizing antibodies (bnAbs) at the molecular level and using this understanding to design immunogens as possible vaccines. BnAbs can protect against virus challenge in animal models, and many such antibodies have been isolated recently. We further propose that studies focused on how best to provide T cell help to B cells that produce bnAbs are crucial for optimal immunization strategies. The synthesis of rational immunogen design and immunization strategies, together with iterative improvements, offers great promise for advancing toward an HIV vaccine.</description><subject>AIDS Vaccines - immunology</subject><subject>Allergy and Immunology - trends</subject><subject>Animals</subject><subject>Antibodies, Neutralizing - blood</subject><subject>Antibodies, Neutralizing - immunology</subject><subject>Antibodies, Viral - blood</subject><subject>Antibodies, Viral - immunology</subject><subject>B-Lymphocytes - immunology</subject><subject>Clinical Trials as Topic</subject><subject>Disease Models, Animal</subject><subject>HIV Infections - prevention & control</subject><subject>Humans</subject><subject>T-Lymphocytes - immunology</subject><issn>1931-3128</issn><issn>1934-6069</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkE1PwkAQhjdGI4j-AQ-mFxMvrTP70bIXE8QPSEi8KNfNdncrJaXFbUvCv7cIEj3NJPO-78w8hFwjRAgY3y8js6hWEQWkEcgIYHhC-igZD2OI5elPjyFDOuyRi7peAggBCZ6THmUw5BKhT25HwWPRurXPyybIKh9MpvNgro3JSxc85bWpNs5vL8lZpovaXR3qgHy8PL-PJ-Hs7XU6Hs1Cw4E2YSY1F4Y6ZJhoKjJg1kKcZtpYg9xylNRa7hKRCi0pWpfGDBwVjqXUCs3ZgDzsc9dtunLWuLLxulDddSvtt6rSufo_KfOF-qw2iglkjMou4O4Q4Kuv1tWNWnU_uKLQpavaWiFlsqPA46ST0r3U-KquvcuOaxDUjq9aqh1fteOrQKqOb2e6-Xvg0fILlH0D3GZ3PQ</recordid><startdate>20121018</startdate><enddate>20121018</enddate><creator>Burton, Dennis R</creator><creator>Ahmed, Rafi</creator><creator>Barouch, Dan H</creator><creator>Butera, Salvatore T</creator><creator>Crotty, Shane</creator><creator>Godzik, Adam</creator><creator>Kaufmann, Daniel E</creator><creator>McElrath, M Juliana</creator><creator>Nussenzweig, Michel C</creator><creator>Pulendran, Bali</creator><creator>Scanlan, Chris N</creator><creator>Schief, William R</creator><creator>Silvestri, Guido</creator><creator>Streeck, Hendrik</creator><creator>Walker, Bruce D</creator><creator>Walker, Laura M</creator><creator>Ward, Andrew B</creator><creator>Wilson, Ian A</creator><creator>Wyatt, Richard</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20121018</creationdate><title>A Blueprint for HIV Vaccine Discovery</title><author>Burton, Dennis R ; Ahmed, Rafi ; Barouch, Dan H ; Butera, Salvatore T ; Crotty, Shane ; Godzik, Adam ; Kaufmann, Daniel E ; McElrath, M Juliana ; Nussenzweig, Michel C ; Pulendran, Bali ; Scanlan, Chris N ; Schief, William R ; Silvestri, Guido ; Streeck, Hendrik ; Walker, Bruce D ; Walker, Laura M ; Ward, Andrew B ; Wilson, Ian A ; Wyatt, Richard</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c402t-f9a45c2e1317a25f03dd06bfacdc14d4192dd4e75b5a921deb630e25e3b2d5a43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>AIDS Vaccines - immunology</topic><topic>Allergy and Immunology - trends</topic><topic>Animals</topic><topic>Antibodies, Neutralizing - blood</topic><topic>Antibodies, Neutralizing - immunology</topic><topic>Antibodies, Viral - blood</topic><topic>Antibodies, Viral - immunology</topic><topic>B-Lymphocytes - immunology</topic><topic>Clinical Trials as Topic</topic><topic>Disease Models, Animal</topic><topic>HIV Infections - prevention & control</topic><topic>Humans</topic><topic>T-Lymphocytes - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Burton, Dennis R</creatorcontrib><creatorcontrib>Ahmed, Rafi</creatorcontrib><creatorcontrib>Barouch, Dan H</creatorcontrib><creatorcontrib>Butera, Salvatore T</creatorcontrib><creatorcontrib>Crotty, Shane</creatorcontrib><creatorcontrib>Godzik, Adam</creatorcontrib><creatorcontrib>Kaufmann, Daniel E</creatorcontrib><creatorcontrib>McElrath, M Juliana</creatorcontrib><creatorcontrib>Nussenzweig, Michel C</creatorcontrib><creatorcontrib>Pulendran, Bali</creatorcontrib><creatorcontrib>Scanlan, Chris N</creatorcontrib><creatorcontrib>Schief, William R</creatorcontrib><creatorcontrib>Silvestri, Guido</creatorcontrib><creatorcontrib>Streeck, Hendrik</creatorcontrib><creatorcontrib>Walker, Bruce D</creatorcontrib><creatorcontrib>Walker, Laura M</creatorcontrib><creatorcontrib>Ward, Andrew B</creatorcontrib><creatorcontrib>Wilson, Ian A</creatorcontrib><creatorcontrib>Wyatt, Richard</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cell host & microbe</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Burton, Dennis R</au><au>Ahmed, Rafi</au><au>Barouch, Dan H</au><au>Butera, Salvatore T</au><au>Crotty, Shane</au><au>Godzik, Adam</au><au>Kaufmann, Daniel E</au><au>McElrath, M Juliana</au><au>Nussenzweig, Michel C</au><au>Pulendran, Bali</au><au>Scanlan, Chris N</au><au>Schief, William R</au><au>Silvestri, Guido</au><au>Streeck, Hendrik</au><au>Walker, Bruce D</au><au>Walker, Laura M</au><au>Ward, Andrew B</au><au>Wilson, Ian A</au><au>Wyatt, Richard</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Blueprint for HIV Vaccine Discovery</atitle><jtitle>Cell host & microbe</jtitle><addtitle>Cell Host Microbe</addtitle><date>2012-10-18</date><risdate>2012</risdate><volume>12</volume><issue>4</issue><spage>396</spage><epage>407</epage><pages>396-407</pages><issn>1931-3128</issn><eissn>1934-6069</eissn><abstract>Despite numerous attempts over many years to develop an HIV vaccine based on classical strategies, none has convincingly succeeded to date. 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| fulltext | fulltext |
| identifier | ISSN: 1931-3128 |
| ispartof | Cell host & microbe, 2012-10, Vol.12 (4), p.396-407 |
| issn | 1931-3128 1934-6069 |
| language | eng |
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| source | MEDLINE; Cell Press Free Archives; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | AIDS Vaccines - immunology Allergy and Immunology - trends Animals Antibodies, Neutralizing - blood Antibodies, Neutralizing - immunology Antibodies, Viral - blood Antibodies, Viral - immunology B-Lymphocytes - immunology Clinical Trials as Topic Disease Models, Animal HIV Infections - prevention & control Humans T-Lymphocytes - immunology |
| title | A Blueprint for HIV Vaccine Discovery |
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