Intervertebral disc degeneration: evidence for two distinct phenotypes

We review the evidence that there are two types of disc degeneration. ‘Endplate‐driven’ disc degeneration involves endplate defects and inwards collapse of the annulus, has a high heritability, mostly affects discs in the upper lumbar and thoracic spine, often starts to develop before age 30 years,...

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Veröffentlicht in:	Journal of anatomy 2012-12, Vol.221 (6), p.497-506
Hauptverfasser:	Adams, Michael A., Dolan, Patricia
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors ageing Back Pain - etiology Back Pain - pathology biomechanics Cumulative Trauma Disorders - complications degeneration Humans intervertebral disc Intervertebral Disc Degeneration - classification Intervertebral Disc Degeneration - etiology Intervertebral Disc Degeneration - physiopathology Phenotype Reviews and Original (Spine Function) Spinal Injuries - complications
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