The role of the c-Jun N-terminal Kinase signaling pathway in skin cancer

The role of the c-Jun N-terminal Kinase signaling pathway in skin cancer

The c-Jun N-terminal Kinases (JNK), along with Erk and p38, constitute the principle members of the mitogen-activated protein kinase (MAPK) family. JNK functions primarily through AP1 family transcription factors to regulate a plethora of cellular processes, including cell proliferation, differentia...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:American journal of cancer research 2012-01, Vol.2 (6), p.691-698
Hauptverfasser: Zhang, Jennifer Y, Selim, Maria Angelica
Format: Artikel
Sprache:eng
Schlagworte:
Review
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 698
container_issue 6
container_start_page 691
container_title American journal of cancer research
container_volume 2
creator Zhang, Jennifer Y
Selim, Maria Angelica
description The c-Jun N-terminal Kinases (JNK), along with Erk and p38, constitute the principle members of the mitogen-activated protein kinase (MAPK) family. JNK functions primarily through AP1 family transcription factors to regulate a plethora of cellular processes, including cell proliferation, differentiation, survival and migration. It also cross-talks and integrates with other signaling pathways in a cell context-specific and cell type-specific manner. The current views of JNK function in various skin cancers and the need of developing JNK subunit-specific inhibitors for cancer type-specific applications have been summarized in this review.
format Article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3512184</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1237091686</sourcerecordid><originalsourceid>FETCH-LOGICAL-p196t-35e093a4274f3e49edff82ff8667b69bb6509fd0644bbe9d1d25e5a7fd6800703</originalsourceid><addsrcrecordid>eNpVUE1LxDAQDaK4y7p_QXL0UshX0-YiyKKuuuhlPZe0nXSjbVqTVtl_b8BV1oF584Z5vAdzguaMpjKRKpOnR3yGliG8kViCUCXUOZoxzpiUNJ2j9XYH2Pct4N7gMfIqeZwcfk5G8J11usVPEQPgYJu4WdfgQY-7L73H1uHwHqHSrgJ_gc6MbgMsD3OBXu9ut6t1snm5f1jdbJKBKjkmPAWiuBYsE4aDUFAbk7PYUmalVGUpU6JMTaQQZQmqpjVLIdWZqWVOSEb4Al3_-A5T2UFdgRu9bovB2077fdFrW_y_OLsrmv6z4CllNBfR4Opg4PuPCcJYdDZU0LbaQT-FgjKeEUVlLqP08jjrL-T3ffwbJTZtuw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1237091686</pqid></control><display><type>article</type><title>The role of the c-Jun N-terminal Kinase signaling pathway in skin cancer</title><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Zhang, Jennifer Y ; Selim, Maria Angelica</creator><creatorcontrib>Zhang, Jennifer Y ; Selim, Maria Angelica</creatorcontrib><description>The c-Jun N-terminal Kinases (JNK), along with Erk and p38, constitute the principle members of the mitogen-activated protein kinase (MAPK) family. JNK functions primarily through AP1 family transcription factors to regulate a plethora of cellular processes, including cell proliferation, differentiation, survival and migration. It also cross-talks and integrates with other signaling pathways in a cell context-specific and cell type-specific manner. The current views of JNK function in various skin cancers and the need of developing JNK subunit-specific inhibitors for cancer type-specific applications have been summarized in this review.</description><identifier>ISSN: 2156-6976</identifier><identifier>EISSN: 2156-6976</identifier><identifier>PMID: 23226615</identifier><language>eng</language><publisher>United States: e-Century Publishing Corporation</publisher><subject>Review</subject><ispartof>American journal of cancer research, 2012-01, Vol.2 (6), p.691-698</ispartof><rights>AJCR Copyright © 2012 2012</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3512184/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3512184/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23226615$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Jennifer Y</creatorcontrib><creatorcontrib>Selim, Maria Angelica</creatorcontrib><title>The role of the c-Jun N-terminal Kinase signaling pathway in skin cancer</title><title>American journal of cancer research</title><addtitle>Am J Cancer Res</addtitle><description>The c-Jun N-terminal Kinases (JNK), along with Erk and p38, constitute the principle members of the mitogen-activated protein kinase (MAPK) family. JNK functions primarily through AP1 family transcription factors to regulate a plethora of cellular processes, including cell proliferation, differentiation, survival and migration. It also cross-talks and integrates with other signaling pathways in a cell context-specific and cell type-specific manner. The current views of JNK function in various skin cancers and the need of developing JNK subunit-specific inhibitors for cancer type-specific applications have been summarized in this review.</description><subject>Review</subject><issn>2156-6976</issn><issn>2156-6976</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNpVUE1LxDAQDaK4y7p_QXL0UshX0-YiyKKuuuhlPZe0nXSjbVqTVtl_b8BV1oF584Z5vAdzguaMpjKRKpOnR3yGliG8kViCUCXUOZoxzpiUNJ2j9XYH2Pct4N7gMfIqeZwcfk5G8J11usVPEQPgYJu4WdfgQY-7L73H1uHwHqHSrgJ_gc6MbgMsD3OBXu9ut6t1snm5f1jdbJKBKjkmPAWiuBYsE4aDUFAbk7PYUmalVGUpU6JMTaQQZQmqpjVLIdWZqWVOSEb4Al3_-A5T2UFdgRu9bovB2077fdFrW_y_OLsrmv6z4CllNBfR4Opg4PuPCcJYdDZU0LbaQT-FgjKeEUVlLqP08jjrL-T3ffwbJTZtuw</recordid><startdate>20120101</startdate><enddate>20120101</enddate><creator>Zhang, Jennifer Y</creator><creator>Selim, Maria Angelica</creator><general>e-Century Publishing Corporation</general><scope>NPM</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20120101</creationdate><title>The role of the c-Jun N-terminal Kinase signaling pathway in skin cancer</title><author>Zhang, Jennifer Y ; Selim, Maria Angelica</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p196t-35e093a4274f3e49edff82ff8667b69bb6509fd0644bbe9d1d25e5a7fd6800703</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Review</topic><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Jennifer Y</creatorcontrib><creatorcontrib>Selim, Maria Angelica</creatorcontrib><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>American journal of cancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Jennifer Y</au><au>Selim, Maria Angelica</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of the c-Jun N-terminal Kinase signaling pathway in skin cancer</atitle><jtitle>American journal of cancer research</jtitle><addtitle>Am J Cancer Res</addtitle><date>2012-01-01</date><risdate>2012</risdate><volume>2</volume><issue>6</issue><spage>691</spage><epage>698</epage><pages>691-698</pages><issn>2156-6976</issn><eissn>2156-6976</eissn><abstract>The c-Jun N-terminal Kinases (JNK), along with Erk and p38, constitute the principle members of the mitogen-activated protein kinase (MAPK) family. JNK functions primarily through AP1 family transcription factors to regulate a plethora of cellular processes, including cell proliferation, differentiation, survival and migration. It also cross-talks and integrates with other signaling pathways in a cell context-specific and cell type-specific manner. The current views of JNK function in various skin cancers and the need of developing JNK subunit-specific inhibitors for cancer type-specific applications have been summarized in this review.</abstract><cop>United States</cop><pub>e-Century Publishing Corporation</pub><pmid>23226615</pmid><tpages>8</tpages></addata></record>
fulltext fulltext
identifier ISSN: 2156-6976
ispartof American journal of cancer research, 2012-01, Vol.2 (6), p.691-698
issn 2156-6976
2156-6976
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3512184
source Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central
subjects Review
title The role of the c-Jun N-terminal Kinase signaling pathway in skin cancer
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T03%3A43%3A19IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20role%20of%20the%20c-Jun%20N-terminal%20Kinase%20signaling%20pathway%20in%20skin%20cancer&rft.jtitle=American%20journal%20of%20cancer%20research&rft.au=Zhang,%20Jennifer%20Y&rft.date=2012-01-01&rft.volume=2&rft.issue=6&rft.spage=691&rft.epage=698&rft.pages=691-698&rft.issn=2156-6976&rft.eissn=2156-6976&rft_id=info:doi/&rft_dat=%3Cproquest_pubme%3E1237091686%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1237091686&rft_id=info:pmid/23226615&rfr_iscdi=true