rpS6 Regulates Blood-Testis Barrier Dynamics By Affecting F-Actin Organization and Protein Recruitment

During spermatogenesis, preleptotene spermatocytes residing near the basement membrane of the seminiferous tubule must traverse the blood-testis barrier (BTB) at stage VIII–IX of the epithelial cycle to continue their development in the adluminal compartment. Unlike other blood-tissue barriers (e.g....

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Veröffentlicht in:	Endocrinology (Philadelphia) 2012-10, Vol.153 (10), p.5036-5048
Hauptverfasser:	Mok, Ka-Wai, Mruk, Dolores D, Silvestrini, Bruno, Cheng, C. Yan
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Actins - metabolism Adhesion Adhesive strength Animals Basement membranes Biological and medical sciences Blood-brain barrier Blood-Testis Barrier - drug effects Blood-Testis Barrier - metabolism Capillaries Cell activation Developmental stages Endoplasmic reticulum Fundamental and applied biological sciences. Psychology Gametocytes Hydrazines - pharmacology Indazoles - pharmacology Male Membranes Permeability Plasma membranes Protein Transport - physiology Proteins Rapamycin Rats Rats, Sprague-Dawley Reproduction-Development Ribosomal protein S6 Ribosomal Protein S6 - metabolism RNA-mediated interference Seminiferous tubule Sertoli cells Sertoli Cells - drug effects Sertoli Cells - metabolism Signal Transduction - drug effects Signal Transduction - physiology siRNA Spermatocytes Spermatogenesis Spermatogenesis - drug effects Spermatogenesis - physiology Tight Junctions - drug effects Tight Junctions - metabolism TOR protein Vertebrates: endocrinology
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