Comparison of localized versus systemic levels of Matrix metalloproteinases (MMPs), its tissue inhibitors (TIMPs) and cytokines in tuberculous and non-tuberculous pleuritis patients
Abstract The interaction of Matrix metalloproteinases (MMPs), its tissue inhibitors (TIMPs) and pro-inflammatory cytokines in response to Mycobacterium tuberculosis (MTB) infection is important to understand the immune response at the site of infection. We compared the levels of MMPs, TIMPs and cyto...
Gespeichert in:
| Veröffentlicht in: | Human immunology 2012-10, Vol.73 (10), p.985-991 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 991 |
|---|---|
| container_issue | 10 |
| container_start_page | 985 |
| container_title | Human immunology |
| container_volume | 73 |
| creator | Sundararajan, Swetha Babu, Subash Das, Sulochana D |
| description | Abstract The interaction of Matrix metalloproteinases (MMPs), its tissue inhibitors (TIMPs) and pro-inflammatory cytokines in response to Mycobacterium tuberculosis (MTB) infection is important to understand the immune response at the site of infection. We compared the levels of MMPs, TIMPs and cytokines in plasma (BL) and pleural fluid (PF) of tuberculosis (TB) and non tuberculosis (NTB) patients. Comparison between BL and PF showed significantly higher levels of MMP-1, TIMP-1 and -3 in TB PF; of MMP-7, -8, -9 in BL of both groups. Also, levels of MMP-1,-8,-9 and TIMP-3 were significantly higher in TB PF compared to NTB. Cytokines INF-γ, TNF-α, and IL-6 significantly increased in PF of both groups. A positive correlation of MMPs with TIMPs in TB, MMP-1 and -9 with IL-6 in TB PF and MMP-9 with IFN-γ in NTB PF was observed. This study implicates the possible usage of MMPs as bio-markers aiding diagnosis in TB pleuritis. |
| doi_str_mv | 10.1016/j.humimm.2012.07.042 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3511911</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0198885912002078</els_id><sourcerecordid>1040999401</sourcerecordid><originalsourceid>FETCH-LOGICAL-c518t-abfe06133ed3898fb8640d3ac47fd4c6816273d71d999e8b13551506ab82c29e3</originalsourceid><addsrcrecordid>eNqFUstu1DAUjRCIlsIfIORlkchgOy9ng1SNeFTqCCTK2nKcG-ZOHTvYzojhv_g_HE0phQ0rSz4vX5-bZc8ZXTHK6te71XYecRxXnDK-os2KlvxBdspE0-aM1fXD7JSyVuRCVO1J9iSEHaW0oU35ODvhXHBa8-o0-7l246Q8BmeJG4hxWhn8AT3Zgw9zIOEQIoyoiYE9mLBwNip6_E5GiMoYN3kXAa0KEMj5ZvMpvHxFMAYSMYQZCNotdhidT-j15QITZXuiD9HdoE0atCTOHXg9G5fyFtA6m9-_mwzMHpMhmVREsDE8zR4NygR4dnueZV_evb1ef8ivPr6_XF9c5bpiIuaqG4DWrCigL0Qrhk7UJe0Lpctm6EtdC1bzpugb1rdtC6JjRVWxitaqE1zzFoqz7M3Rd5q7EXqdsr0ycvI4Kn-QTqH8G7G4lV_dXhYVYy1jyeD81sC7bzOEKEcMGoxRFtJoktGSpuySLtTySNXeheBhuIthVC6Ny508Ni6XxiVtZGo8yV7cf-Kd6HfFf2ZI9cEewcug0ydq6NGDjrJ3-L-Efw20QYtpUW7gAGHnZm9TCZLJkDTy87J1y9IxTimnjSh-ATNt2Zk</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1040999401</pqid></control><display><type>article</type><title>Comparison of localized versus systemic levels of Matrix metalloproteinases (MMPs), its tissue inhibitors (TIMPs) and cytokines in tuberculous and non-tuberculous pleuritis patients</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Sundararajan, Swetha ; Babu, Subash ; Das, Sulochana D</creator><creatorcontrib>Sundararajan, Swetha ; Babu, Subash ; Das, Sulochana D</creatorcontrib><description>Abstract The interaction of Matrix metalloproteinases (MMPs), its tissue inhibitors (TIMPs) and pro-inflammatory cytokines in response to Mycobacterium tuberculosis (MTB) infection is important to understand the immune response at the site of infection. We compared the levels of MMPs, TIMPs and cytokines in plasma (BL) and pleural fluid (PF) of tuberculosis (TB) and non tuberculosis (NTB) patients. Comparison between BL and PF showed significantly higher levels of MMP-1, TIMP-1 and -3 in TB PF; of MMP-7, -8, -9 in BL of both groups. Also, levels of MMP-1,-8,-9 and TIMP-3 were significantly higher in TB PF compared to NTB. Cytokines INF-γ, TNF-α, and IL-6 significantly increased in PF of both groups. A positive correlation of MMPs with TIMPs in TB, MMP-1 and -9 with IL-6 in TB PF and MMP-9 with IFN-γ in NTB PF was observed. This study implicates the possible usage of MMPs as bio-markers aiding diagnosis in TB pleuritis.</description><identifier>ISSN: 0198-8859</identifier><identifier>EISSN: 1879-1166</identifier><identifier>DOI: 10.1016/j.humimm.2012.07.042</identifier><identifier>PMID: 22820625</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Allergy and Immunology ; Cytokines - blood ; Female ; Humans ; Male ; Matrix Metalloproteinases - blood ; Middle Aged ; Mycobacterium tuberculosis ; Pleural Effusion - immunology ; Pleural Effusion - microbiology ; Pleurisy - immunology ; Tissue Inhibitor of Metalloproteinases - blood ; Tuberculosis, Pleural - immunology ; Tuberculosis, Pleural - microbiology ; Young Adult</subject><ispartof>Human immunology, 2012-10, Vol.73 (10), p.985-991</ispartof><rights>American Society for Histocompatibility and Immunogenetics</rights><rights>2012 American Society for Histocompatibility and Immunogenetics</rights><rights>Copyright © 2012 American Society for Histocompatibility and Immunogenetics. All rights reserved.</rights><rights>2012 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved. 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c518t-abfe06133ed3898fb8640d3ac47fd4c6816273d71d999e8b13551506ab82c29e3</citedby><cites>FETCH-LOGICAL-c518t-abfe06133ed3898fb8640d3ac47fd4c6816273d71d999e8b13551506ab82c29e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.humimm.2012.07.042$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22820625$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sundararajan, Swetha</creatorcontrib><creatorcontrib>Babu, Subash</creatorcontrib><creatorcontrib>Das, Sulochana D</creatorcontrib><title>Comparison of localized versus systemic levels of Matrix metalloproteinases (MMPs), its tissue inhibitors (TIMPs) and cytokines in tuberculous and non-tuberculous pleuritis patients</title><title>Human immunology</title><addtitle>Hum Immunol</addtitle><description>Abstract The interaction of Matrix metalloproteinases (MMPs), its tissue inhibitors (TIMPs) and pro-inflammatory cytokines in response to Mycobacterium tuberculosis (MTB) infection is important to understand the immune response at the site of infection. We compared the levels of MMPs, TIMPs and cytokines in plasma (BL) and pleural fluid (PF) of tuberculosis (TB) and non tuberculosis (NTB) patients. Comparison between BL and PF showed significantly higher levels of MMP-1, TIMP-1 and -3 in TB PF; of MMP-7, -8, -9 in BL of both groups. Also, levels of MMP-1,-8,-9 and TIMP-3 were significantly higher in TB PF compared to NTB. Cytokines INF-γ, TNF-α, and IL-6 significantly increased in PF of both groups. A positive correlation of MMPs with TIMPs in TB, MMP-1 and -9 with IL-6 in TB PF and MMP-9 with IFN-γ in NTB PF was observed. This study implicates the possible usage of MMPs as bio-markers aiding diagnosis in TB pleuritis.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Allergy and Immunology</subject><subject>Cytokines - blood</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Matrix Metalloproteinases - blood</subject><subject>Middle Aged</subject><subject>Mycobacterium tuberculosis</subject><subject>Pleural Effusion - immunology</subject><subject>Pleural Effusion - microbiology</subject><subject>Pleurisy - immunology</subject><subject>Tissue Inhibitor of Metalloproteinases - blood</subject><subject>Tuberculosis, Pleural - immunology</subject><subject>Tuberculosis, Pleural - microbiology</subject><subject>Young Adult</subject><issn>0198-8859</issn><issn>1879-1166</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUstu1DAUjRCIlsIfIORlkchgOy9ng1SNeFTqCCTK2nKcG-ZOHTvYzojhv_g_HE0phQ0rSz4vX5-bZc8ZXTHK6te71XYecRxXnDK-os2KlvxBdspE0-aM1fXD7JSyVuRCVO1J9iSEHaW0oU35ODvhXHBa8-o0-7l246Q8BmeJG4hxWhn8AT3Zgw9zIOEQIoyoiYE9mLBwNip6_E5GiMoYN3kXAa0KEMj5ZvMpvHxFMAYSMYQZCNotdhidT-j15QITZXuiD9HdoE0atCTOHXg9G5fyFtA6m9-_mwzMHpMhmVREsDE8zR4NygR4dnueZV_evb1ef8ivPr6_XF9c5bpiIuaqG4DWrCigL0Qrhk7UJe0Lpctm6EtdC1bzpugb1rdtC6JjRVWxitaqE1zzFoqz7M3Rd5q7EXqdsr0ycvI4Kn-QTqH8G7G4lV_dXhYVYy1jyeD81sC7bzOEKEcMGoxRFtJoktGSpuySLtTySNXeheBhuIthVC6Ny508Ni6XxiVtZGo8yV7cf-Kd6HfFf2ZI9cEewcug0ydq6NGDjrJ3-L-Efw20QYtpUW7gAGHnZm9TCZLJkDTy87J1y9IxTimnjSh-ATNt2Zk</recordid><startdate>20121001</startdate><enddate>20121001</enddate><creator>Sundararajan, Swetha</creator><creator>Babu, Subash</creator><creator>Das, Sulochana D</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20121001</creationdate><title>Comparison of localized versus systemic levels of Matrix metalloproteinases (MMPs), its tissue inhibitors (TIMPs) and cytokines in tuberculous and non-tuberculous pleuritis patients</title><author>Sundararajan, Swetha ; Babu, Subash ; Das, Sulochana D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c518t-abfe06133ed3898fb8640d3ac47fd4c6816273d71d999e8b13551506ab82c29e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Allergy and Immunology</topic><topic>Cytokines - blood</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Matrix Metalloproteinases - blood</topic><topic>Middle Aged</topic><topic>Mycobacterium tuberculosis</topic><topic>Pleural Effusion - immunology</topic><topic>Pleural Effusion - microbiology</topic><topic>Pleurisy - immunology</topic><topic>Tissue Inhibitor of Metalloproteinases - blood</topic><topic>Tuberculosis, Pleural - immunology</topic><topic>Tuberculosis, Pleural - microbiology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sundararajan, Swetha</creatorcontrib><creatorcontrib>Babu, Subash</creatorcontrib><creatorcontrib>Das, Sulochana D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Human immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sundararajan, Swetha</au><au>Babu, Subash</au><au>Das, Sulochana D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of localized versus systemic levels of Matrix metalloproteinases (MMPs), its tissue inhibitors (TIMPs) and cytokines in tuberculous and non-tuberculous pleuritis patients</atitle><jtitle>Human immunology</jtitle><addtitle>Hum Immunol</addtitle><date>2012-10-01</date><risdate>2012</risdate><volume>73</volume><issue>10</issue><spage>985</spage><epage>991</epage><pages>985-991</pages><issn>0198-8859</issn><eissn>1879-1166</eissn><abstract>Abstract The interaction of Matrix metalloproteinases (MMPs), its tissue inhibitors (TIMPs) and pro-inflammatory cytokines in response to Mycobacterium tuberculosis (MTB) infection is important to understand the immune response at the site of infection. We compared the levels of MMPs, TIMPs and cytokines in plasma (BL) and pleural fluid (PF) of tuberculosis (TB) and non tuberculosis (NTB) patients. Comparison between BL and PF showed significantly higher levels of MMP-1, TIMP-1 and -3 in TB PF; of MMP-7, -8, -9 in BL of both groups. Also, levels of MMP-1,-8,-9 and TIMP-3 were significantly higher in TB PF compared to NTB. Cytokines INF-γ, TNF-α, and IL-6 significantly increased in PF of both groups. A positive correlation of MMPs with TIMPs in TB, MMP-1 and -9 with IL-6 in TB PF and MMP-9 with IFN-γ in NTB PF was observed. This study implicates the possible usage of MMPs as bio-markers aiding diagnosis in TB pleuritis.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>22820625</pmid><doi>10.1016/j.humimm.2012.07.042</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0198-8859 |
| ispartof | Human immunology, 2012-10, Vol.73 (10), p.985-991 |
| issn | 0198-8859 1879-1166 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3511911 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Adolescent Adult Allergy and Immunology Cytokines - blood Female Humans Male Matrix Metalloproteinases - blood Middle Aged Mycobacterium tuberculosis Pleural Effusion - immunology Pleural Effusion - microbiology Pleurisy - immunology Tissue Inhibitor of Metalloproteinases - blood Tuberculosis, Pleural - immunology Tuberculosis, Pleural - microbiology Young Adult |
| title | Comparison of localized versus systemic levels of Matrix metalloproteinases (MMPs), its tissue inhibitors (TIMPs) and cytokines in tuberculous and non-tuberculous pleuritis patients |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-01T17%3A47%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Comparison%20of%20localized%20versus%20systemic%20levels%20of%20Matrix%20metalloproteinases%20(MMPs),%20its%20tissue%20inhibitors%20(TIMPs)%20and%20cytokines%20in%20tuberculous%20and%20non-tuberculous%20pleuritis%20patients&rft.jtitle=Human%20immunology&rft.au=Sundararajan,%20Swetha&rft.date=2012-10-01&rft.volume=73&rft.issue=10&rft.spage=985&rft.epage=991&rft.pages=985-991&rft.issn=0198-8859&rft.eissn=1879-1166&rft_id=info:doi/10.1016/j.humimm.2012.07.042&rft_dat=%3Cproquest_pubme%3E1040999401%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1040999401&rft_id=info:pmid/22820625&rft_els_id=1_s2_0_S0198885912002078&rfr_iscdi=true |