Functional Analysis of the Relationship between Vpx and the Restriction Factor SAMHD1

SAMHD1 is a newly identified restriction factor that targets lentiviruses in myeloid cells and is countered by the SIVSM/HIV-2 Vpx protein. By analyzing a large panel of Vpx mutants, we identify several residues throughout the 3-helix bundle predicted for Vpx that impair both its functionality and i...

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Veröffentlicht in:	The Journal of biological chemistry 2012-11, Vol.287 (49), p.41210-41217
Hauptverfasser:	Berger, Gregory, Turpin, Jocelyn, Cordeil, Stéphanie, Tartour, Kevin, Nguyen, Xuan-Nhi, Mahieux, Renaud, Cimarelli, Andrea
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiviral Agents Antiviral Agents - metabolism Cell Nucleus Cell Nucleus - metabolism Cytoplasm Cytoplasm - metabolism Dendritic Cells Dendritic Cells - virology HEK293 Cells HeLa Cells HIV HIV-1 HIV-2 HIV-2 - metabolism Humans Life Sciences Macrophages Macrophages - virology Mice Microbiology Monomeric GTP-Binding Proteins Monomeric GTP-Binding Proteins - metabolism Monomeric GTP-Binding Proteins - physiology Mutation NIH 3T3 Cells Protein Binding Protein Degradation Retrovirus SAM Domain and HD Domain-Containing Protein 1 SAMHD1 Viral Protein Viral Regulatory and Accessory Proteins Viral Regulatory and Accessory Proteins - metabolism Virulence Factors Virulence Factors - metabolism Vpx
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