Genome-wide meta-analysis points to CTC1 and ZNF676 as genes regulating telomere homeostasis in humans

Leukocyte telomere length (LTL) is associated with a number of common age-related diseases and is a heritable trait. Previous genome-wide association studies (GWASs) identified two loci on chromosomes 3q26.2 (TERC) and 10q24.33 (OBFC1) that are associated with the inter-individual LTL variation. We...

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Veröffentlicht in:	Human molecular genetics 2012-12, Vol.21 (24), p.5385-5394
Hauptverfasser:	MANGINO, Massimo, HWANG, Shih-Jen, WEI CHEN, SRINIVASAN, Sathanur R, KART, Jeremy D, BENETOS, Athanase, EL SHAMIEH, Said, VISVIKIS-SIEST, Sophie, CHRISTENSEN, Kaare, BERENSON, Gerald S, VALDES, Ana M, VINUELA, Ana, SPECTOR, Timothy D, GARCIA, Melissa, ARNETT, Donna K, BROECKEL, Ulrich, PROVINCE, Michael A, PANKOW, James S, KAMMERER, Candace, YONGMEI LIU, NALLS, Michael, TISHKOFF, Sarah, THOMAS, Fridtjof, HUNT, Steven C, ZIV, Elad, PSATY, Bruce M, BIS, Joshua C, ROTTER, Jerome I, TAYLOR, Kent D, SMITH, Erin, SCHORK, Nicholas J, LEVY, Daniel, AVIV, Abraham, KIMURA, Masayuki, FITZPATRICK, Annette L, CHRISTIANSEN, Lene, PETERSEN, Inge, ELBERS, Clara C, HARRIS, Tamara
Format:	Artikel
Sprache:	eng
Schlagworte:	Association Studies Biological and medical sciences Fundamental and applied biological sciences. Psychology Genetics of eukaryotes. Biological and molecular evolution Genome-Wide Association Study Humans Kruppel-Like Transcription Factors Molecular and cellular biology Telomere - metabolism Telomere Homeostasis - genetics Telomere-Binding Proteins - genetics
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