The Onco-Embryonic Antigen ROR1 Is Expressed by a Variety of Human Cancers

ROR1 is an orphan-receptor tyrosine-kinase-like surface antigen that is expressed by many tissues during embryogenesis, some B-cell malignancies, and various cancer cell lines but not by virtually all normal adult tissues. Here, we report that large proportions of many different human cancers also e...

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Veröffentlicht in:	The American journal of pathology 2012-12, Vol.181 (6), p.1903-1910
Hauptverfasser:	Zhang, Suping, Chen, Liguang, Wang-Rodriguez, Jessica, Zhang, Ling, Cui, Bing, Frankel, Wendy, Wu, Rongrong, Kipps, Thomas J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Animals Biological and medical sciences Cell Differentiation Cell Line, Tumor Cell Proliferation CHO Cells Cricetinae Cricetulus Cyclic AMP Response Element-Binding Protein - metabolism Enzyme Activation Gene Expression Regulation, Neoplastic Humans Investigative techniques, diagnostic techniques (general aspects) Medical sciences Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology Oncogene Proteins - genetics Oncogene Proteins - metabolism Pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Proto-Oncogene Proteins c-akt - metabolism Receptor Tyrosine Kinase-like Orphan Receptors - genetics Receptor Tyrosine Kinase-like Orphan Receptors - metabolism Short Communication
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