Pharmacological evaluation and preliminary pharmacokinetics studies of a new diclofenac prodrug without gastric ulceration effect

Long-term nonsteroidal anti-inflammatory drugs (NSAIDs) therapy has been associated with several adverse effects such as gastric ulceration and cardiovascular events. Among the molecular modifications strategies, the prodrug approach is a useful tool to discover new safe NSAIDs. The 1-(2,6-dichlorop...

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Veröffentlicht in:	International journal of molecular sciences 2012-11, Vol.13 (11), p.15305-15320
Hauptverfasser:	Santos, Jean Leandro Dos, Moreira, Vanessa, Campos, Michel Leandro, Chelucci, Rafael Consolin, Barbieri, Karina Pereira, de Castro Souto, Pollyana Cristina Maggio, Matsubara, Márcio Hideki, Teixeira, Catarina, Bosquesi, Priscila Longhin, Peccinini, Rosângela Gonçalves, Chin, Chung Man
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Animals Anti-inflammatory agents Anti-Inflammatory Agents, Non-Steroidal - adverse effects Anti-Inflammatory Agents, Non-Steroidal - chemistry Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics Anti-Inflammatory Agents, Non-Steroidal - pharmacology Carrageenan - adverse effects Cyclooxygenase 2 - genetics Cyclooxygenase 2 - metabolism Diclofenac - administration & dosage Diclofenac - adverse effects Diclofenac - analogs & derivatives Diclofenac - chemistry Diclofenac - pharmacokinetics Diclofenac - pharmacology Dinoprostone - biosynthesis Disease Models, Animal Edema Edema - chemically induced Edema - drug therapy Inflammation Leukocytes - metabolism Male Mice Molecular Structure Nonsteroidal anti-inflammatory drugs Peritoneal Cavity - pathology Pharmaceutical industry Pharmacokinetics Prodrugs Rats Stomach Ulcer - chemically induced Thrombosis
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