Blockade of dopamine D3 receptors in the nucleus accumbens and central amygdala inhibits incubation of cocaine craving in rats

Cue‐induced drug seeking progressively increases over time of withdrawal from drug self‐administration in rats, a phenomenon called ‘incubation of craving’. The underlying mechanisms have been linked to increased expression of brain‐derived neurotrophic factor and GluR2‐lacking AMPA receptors in the...

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Veröffentlicht in:	Addiction biology 2013-07, Vol.18 (4), p.665-677
Hauptverfasser:	Xi, Zheng-Xiong, Li, Xia, Li, Jie, Peng, Xiao-Qing, Song, Rui, Gaál, József, Gardner, Eliot L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amygdala - drug effects Amygdala - metabolism Analysis of Variance Animals Cocaine Cocaine - administration & dosage Cocaine-Related Disorders - drug therapy Cocaine-Related Disorders - metabolism Cocaine-Related Disorders - psychology craving Cues D3 receptor Disease Models, Animal dopamine Dopamine Antagonists - administration & dosage Dopamine Antagonists - pharmacology Dose-Response Relationship, Drug drug seeking Drug-Seeking Behavior - drug effects Drug-Seeking Behavior - physiology Humans incubation Locomotion - drug effects Male Microinjections Nitriles - administration & dosage Nitriles - pharmacology Nucleus Accumbens - drug effects Nucleus Accumbens - metabolism Rats Receptors, Dopamine D3 - antagonists & inhibitors Receptors, Dopamine D3 - metabolism Receptors, Dopamine D3 - physiology Reinforcement (Psychology) relapse SB-277011A Secondary Prevention Self Administration - methods Sucrose - administration & dosage Tetrahydroisoquinolines - administration & dosage Tetrahydroisoquinolines - pharmacology Time Factors
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