Blockade of dopamine D3 receptors in the nucleus accumbens and central amygdala inhibits incubation of cocaine craving in rats
Cue‐induced drug seeking progressively increases over time of withdrawal from drug self‐administration in rats, a phenomenon called ‘incubation of craving’. The underlying mechanisms have been linked to increased expression of brain‐derived neurotrophic factor and GluR2‐lacking AMPA receptors in the...
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| Veröffentlicht in: | Addiction biology 2013-07, Vol.18 (4), p.665-677 |
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| creator | Xi, Zheng-Xiong Li, Xia Li, Jie Peng, Xiao-Qing Song, Rui Gaál, József Gardner, Eliot L. |
| description | Cue‐induced drug seeking progressively increases over time of withdrawal from drug self‐administration in rats, a phenomenon called ‘incubation of craving’. The underlying mechanisms have been linked to increased expression of brain‐derived neurotrophic factor and GluR2‐lacking AMPA receptors in the mesolimbic dopamine (DA) system and also to increased extracellular signal‐regulated kinase activation in the central amygdala (CeA). However, it remains unclear whether any DA mechanism is also involved in incubation of craving. Recent research demonstrates that cue‐induced cocaine seeking appears to parallel increased DA D3, but not D1 or D2, receptor expression in the nucleus accumbens (NAc) of rats over time of withdrawal, suggesting possible involvement of D3 receptors (D3Rs) in incubation of cocaine craving. Here, we report that systemic or local administration of SB‐277011A, a highly selective D3R antagonist, into the NAc (core and shell) or the CeA, but not the dorsal striatum or basolateral amygdala, significantly inhibits expression of incubation of cocaine craving in rats after 2–30 days of withdrawal from previous cocaine self‐administration but had no effect on sucrose‐seeking behavior in rats after 10–30 days of withdrawal. These data suggest that DA D3Rs in both the NAc and the CeA play an important role in incubation of cocaine craving in rats and support the potential utility of D3R antagonists in the treatment of cocaine addiction. |
| doi_str_mv | 10.1111/j.1369-1600.2012.00486.x |
| format | Article |
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The underlying mechanisms have been linked to increased expression of brain‐derived neurotrophic factor and GluR2‐lacking AMPA receptors in the mesolimbic dopamine (DA) system and also to increased extracellular signal‐regulated kinase activation in the central amygdala (CeA). However, it remains unclear whether any DA mechanism is also involved in incubation of craving. Recent research demonstrates that cue‐induced cocaine seeking appears to parallel increased DA D3, but not D1 or D2, receptor expression in the nucleus accumbens (NAc) of rats over time of withdrawal, suggesting possible involvement of D3 receptors (D3Rs) in incubation of cocaine craving. Here, we report that systemic or local administration of SB‐277011A, a highly selective D3R antagonist, into the NAc (core and shell) or the CeA, but not the dorsal striatum or basolateral amygdala, significantly inhibits expression of incubation of cocaine craving in rats after 2–30 days of withdrawal from previous cocaine self‐administration but had no effect on sucrose‐seeking behavior in rats after 10–30 days of withdrawal. These data suggest that DA D3Rs in both the NAc and the CeA play an important role in incubation of cocaine craving in rats and support the potential utility of D3R antagonists in the treatment of cocaine addiction.</description><identifier>ISSN: 1355-6215</identifier><identifier>EISSN: 1369-1600</identifier><identifier>DOI: 10.1111/j.1369-1600.2012.00486.x</identifier><identifier>PMID: 22913325</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject><![CDATA[Amygdala - drug effects ; Amygdala - metabolism ; Analysis of Variance ; Animals ; Cocaine ; Cocaine - administration & dosage ; Cocaine-Related Disorders - drug therapy ; Cocaine-Related Disorders - metabolism ; Cocaine-Related Disorders - psychology ; craving ; Cues ; D3 receptor ; Disease Models, Animal ; dopamine ; Dopamine Antagonists - administration & dosage ; Dopamine Antagonists - pharmacology ; Dose-Response Relationship, Drug ; drug seeking ; Drug-Seeking Behavior - drug effects ; Drug-Seeking Behavior - physiology ; Humans ; incubation ; Locomotion - drug effects ; Male ; Microinjections ; Nitriles - administration & dosage ; Nitriles - pharmacology ; Nucleus Accumbens - drug effects ; Nucleus Accumbens - metabolism ; Rats ; Receptors, Dopamine D3 - antagonists & inhibitors ; Receptors, Dopamine D3 - metabolism ; Receptors, Dopamine D3 - physiology ; Reinforcement (Psychology) ; relapse ; SB-277011A ; Secondary Prevention ; Self Administration - methods ; Sucrose - administration & dosage ; Tetrahydroisoquinolines - administration & dosage ; Tetrahydroisoquinolines - pharmacology ; Time Factors]]></subject><ispartof>Addiction biology, 2013-07, Vol.18 (4), p.665-677</ispartof><rights>2012 The Authors, Addiction Biology © 2012 Society for the Study of Addiction</rights><rights>2012 The Authors, Addiction Biology © 2012 Society for the Study of Addiction.</rights><rights>2013 Society for the Study of Addiction</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1369-1600.2012.00486.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1369-1600.2012.00486.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22913325$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xi, Zheng-Xiong</creatorcontrib><creatorcontrib>Li, Xia</creatorcontrib><creatorcontrib>Li, Jie</creatorcontrib><creatorcontrib>Peng, Xiao-Qing</creatorcontrib><creatorcontrib>Song, Rui</creatorcontrib><creatorcontrib>Gaál, József</creatorcontrib><creatorcontrib>Gardner, Eliot L.</creatorcontrib><title>Blockade of dopamine D3 receptors in the nucleus accumbens and central amygdala inhibits incubation of cocaine craving in rats</title><title>Addiction biology</title><addtitle>Addiction Biology</addtitle><description>Cue‐induced drug seeking progressively increases over time of withdrawal from drug self‐administration in rats, a phenomenon called ‘incubation of craving’. The underlying mechanisms have been linked to increased expression of brain‐derived neurotrophic factor and GluR2‐lacking AMPA receptors in the mesolimbic dopamine (DA) system and also to increased extracellular signal‐regulated kinase activation in the central amygdala (CeA). However, it remains unclear whether any DA mechanism is also involved in incubation of craving. Recent research demonstrates that cue‐induced cocaine seeking appears to parallel increased DA D3, but not D1 or D2, receptor expression in the nucleus accumbens (NAc) of rats over time of withdrawal, suggesting possible involvement of D3 receptors (D3Rs) in incubation of cocaine craving. Here, we report that systemic or local administration of SB‐277011A, a highly selective D3R antagonist, into the NAc (core and shell) or the CeA, but not the dorsal striatum or basolateral amygdala, significantly inhibits expression of incubation of cocaine craving in rats after 2–30 days of withdrawal from previous cocaine self‐administration but had no effect on sucrose‐seeking behavior in rats after 10–30 days of withdrawal. These data suggest that DA D3Rs in both the NAc and the CeA play an important role in incubation of cocaine craving in rats and support the potential utility of D3R antagonists in the treatment of cocaine addiction.</description><subject>Amygdala - drug effects</subject><subject>Amygdala - metabolism</subject><subject>Analysis of Variance</subject><subject>Animals</subject><subject>Cocaine</subject><subject>Cocaine - administration & dosage</subject><subject>Cocaine-Related Disorders - drug therapy</subject><subject>Cocaine-Related Disorders - metabolism</subject><subject>Cocaine-Related Disorders - psychology</subject><subject>craving</subject><subject>Cues</subject><subject>D3 receptor</subject><subject>Disease Models, Animal</subject><subject>dopamine</subject><subject>Dopamine Antagonists - administration & dosage</subject><subject>Dopamine Antagonists - pharmacology</subject><subject>Dose-Response Relationship, Drug</subject><subject>drug seeking</subject><subject>Drug-Seeking Behavior - drug effects</subject><subject>Drug-Seeking Behavior - physiology</subject><subject>Humans</subject><subject>incubation</subject><subject>Locomotion - drug effects</subject><subject>Male</subject><subject>Microinjections</subject><subject>Nitriles - administration & dosage</subject><subject>Nitriles - pharmacology</subject><subject>Nucleus Accumbens - drug effects</subject><subject>Nucleus Accumbens - metabolism</subject><subject>Rats</subject><subject>Receptors, Dopamine D3 - antagonists & inhibitors</subject><subject>Receptors, Dopamine D3 - metabolism</subject><subject>Receptors, Dopamine D3 - physiology</subject><subject>Reinforcement (Psychology)</subject><subject>relapse</subject><subject>SB-277011A</subject><subject>Secondary Prevention</subject><subject>Self Administration - methods</subject><subject>Sucrose - administration & dosage</subject><subject>Tetrahydroisoquinolines - administration & dosage</subject><subject>Tetrahydroisoquinolines - pharmacology</subject><subject>Time Factors</subject><issn>1355-6215</issn><issn>1369-1600</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkV9v0zAUxS3ExMbgKyBLPCf4T-3EEkLaWhhI1fYCQuLlynGc1l1iFyfZ2hc-Ow4t1eYXX-mc8_OVD0KYkpym82GTUy5VRiUhOSOU5YTMSpnvXqCLk_BymoXIJKPiHL3u-w1JzkLwV-icMUU5Z-IC_blug7nXtcWhwXXY6s55ixccR2vsdgixx87jYW2xH01rxx5rY8ausj5NvsbG-iHqFutuv6p1q5N77So3TDEzVnpwwU9oE4yeyCbqB-dXEzTqoX-Dzhrd9vbt8b5EP758_j7_mi3vbr7Nr5aZ44TIjEklecm5VbKoqrJQxCgheDOzFSsbJqWksqyTo1FNTQ03shSSlbNK2kKpuuCX6NOBux2rztbHrWEbXafjHoJ28Fzxbg2r8ABcEMUES4D3R0AMv0fbD7AJY_RpZ6AzyUnBaSmS693TZ078__-dDB8PhkfX2v1JpwSmXmEDU30w1QdTr_CvV9jB1eI6DSmeHeKuH-zuFNfxHmTBCwE_b29gKRbFvFzewi_-F282pfU</recordid><startdate>201307</startdate><enddate>201307</enddate><creator>Xi, Zheng-Xiong</creator><creator>Li, Xia</creator><creator>Li, Jie</creator><creator>Peng, Xiao-Qing</creator><creator>Song, Rui</creator><creator>Gaál, József</creator><creator>Gardner, Eliot L.</creator><general>Blackwell Publishing Ltd</general><general>John Wiley & Sons, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QG</scope><scope>7T5</scope><scope>7TM</scope><scope>H94</scope><scope>5PM</scope></search><sort><creationdate>201307</creationdate><title>Blockade of dopamine D3 receptors in the nucleus accumbens and central amygdala inhibits incubation of cocaine craving in rats</title><author>Xi, Zheng-Xiong ; Li, Xia ; Li, Jie ; Peng, Xiao-Qing ; Song, Rui ; Gaál, József ; Gardner, Eliot L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i3006-26963833e967bb8790c9553f4eb28f2666168d383f9fd1c3c6856284b6e799d73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Amygdala - drug effects</topic><topic>Amygdala - metabolism</topic><topic>Analysis of Variance</topic><topic>Animals</topic><topic>Cocaine</topic><topic>Cocaine - administration & dosage</topic><topic>Cocaine-Related Disorders - drug therapy</topic><topic>Cocaine-Related Disorders - metabolism</topic><topic>Cocaine-Related Disorders - psychology</topic><topic>craving</topic><topic>Cues</topic><topic>D3 receptor</topic><topic>Disease Models, Animal</topic><topic>dopamine</topic><topic>Dopamine Antagonists - administration & dosage</topic><topic>Dopamine Antagonists - pharmacology</topic><topic>Dose-Response Relationship, Drug</topic><topic>drug seeking</topic><topic>Drug-Seeking Behavior - drug effects</topic><topic>Drug-Seeking Behavior - physiology</topic><topic>Humans</topic><topic>incubation</topic><topic>Locomotion - drug effects</topic><topic>Male</topic><topic>Microinjections</topic><topic>Nitriles - administration & dosage</topic><topic>Nitriles - pharmacology</topic><topic>Nucleus Accumbens - drug effects</topic><topic>Nucleus Accumbens - metabolism</topic><topic>Rats</topic><topic>Receptors, Dopamine D3 - antagonists & inhibitors</topic><topic>Receptors, Dopamine D3 - metabolism</topic><topic>Receptors, Dopamine D3 - physiology</topic><topic>Reinforcement (Psychology)</topic><topic>relapse</topic><topic>SB-277011A</topic><topic>Secondary Prevention</topic><topic>Self Administration - methods</topic><topic>Sucrose - administration & dosage</topic><topic>Tetrahydroisoquinolines - administration & dosage</topic><topic>Tetrahydroisoquinolines - pharmacology</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xi, Zheng-Xiong</creatorcontrib><creatorcontrib>Li, Xia</creatorcontrib><creatorcontrib>Li, Jie</creatorcontrib><creatorcontrib>Peng, Xiao-Qing</creatorcontrib><creatorcontrib>Song, Rui</creatorcontrib><creatorcontrib>Gaál, József</creatorcontrib><creatorcontrib>Gardner, Eliot L.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Animal Behavior Abstracts</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Addiction biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xi, Zheng-Xiong</au><au>Li, Xia</au><au>Li, Jie</au><au>Peng, Xiao-Qing</au><au>Song, Rui</au><au>Gaál, József</au><au>Gardner, Eliot L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Blockade of dopamine D3 receptors in the nucleus accumbens and central amygdala inhibits incubation of cocaine craving in rats</atitle><jtitle>Addiction biology</jtitle><addtitle>Addiction Biology</addtitle><date>2013-07</date><risdate>2013</risdate><volume>18</volume><issue>4</issue><spage>665</spage><epage>677</epage><pages>665-677</pages><issn>1355-6215</issn><eissn>1369-1600</eissn><abstract>Cue‐induced drug seeking progressively increases over time of withdrawal from drug self‐administration in rats, a phenomenon called ‘incubation of craving’. The underlying mechanisms have been linked to increased expression of brain‐derived neurotrophic factor and GluR2‐lacking AMPA receptors in the mesolimbic dopamine (DA) system and also to increased extracellular signal‐regulated kinase activation in the central amygdala (CeA). However, it remains unclear whether any DA mechanism is also involved in incubation of craving. Recent research demonstrates that cue‐induced cocaine seeking appears to parallel increased DA D3, but not D1 or D2, receptor expression in the nucleus accumbens (NAc) of rats over time of withdrawal, suggesting possible involvement of D3 receptors (D3Rs) in incubation of cocaine craving. Here, we report that systemic or local administration of SB‐277011A, a highly selective D3R antagonist, into the NAc (core and shell) or the CeA, but not the dorsal striatum or basolateral amygdala, significantly inhibits expression of incubation of cocaine craving in rats after 2–30 days of withdrawal from previous cocaine self‐administration but had no effect on sucrose‐seeking behavior in rats after 10–30 days of withdrawal. These data suggest that DA D3Rs in both the NAc and the CeA play an important role in incubation of cocaine craving in rats and support the potential utility of D3R antagonists in the treatment of cocaine addiction.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>22913325</pmid><doi>10.1111/j.1369-1600.2012.00486.x</doi><tpages>13</tpages></addata></record> |
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| subjects | Amygdala - drug effects Amygdala - metabolism Analysis of Variance Animals Cocaine Cocaine - administration & dosage Cocaine-Related Disorders - drug therapy Cocaine-Related Disorders - metabolism Cocaine-Related Disorders - psychology craving Cues D3 receptor Disease Models, Animal dopamine Dopamine Antagonists - administration & dosage Dopamine Antagonists - pharmacology Dose-Response Relationship, Drug drug seeking Drug-Seeking Behavior - drug effects Drug-Seeking Behavior - physiology Humans incubation Locomotion - drug effects Male Microinjections Nitriles - administration & dosage Nitriles - pharmacology Nucleus Accumbens - drug effects Nucleus Accumbens - metabolism Rats Receptors, Dopamine D3 - antagonists & inhibitors Receptors, Dopamine D3 - metabolism Receptors, Dopamine D3 - physiology Reinforcement (Psychology) relapse SB-277011A Secondary Prevention Self Administration - methods Sucrose - administration & dosage Tetrahydroisoquinolines - administration & dosage Tetrahydroisoquinolines - pharmacology Time Factors |
| title | Blockade of dopamine D3 receptors in the nucleus accumbens and central amygdala inhibits incubation of cocaine craving in rats |
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