Developmental pathways to amygdala-prefrontal function and internalizing symptoms in adolescence
The authors assessed the contributions of early life stress (ELS) and childhood cortisol levels to adolescent resting-state functional connectivity. In females, ELS predicted increased cortisol levels in childhood, which predicted decreased amygdala-ventromedial prefrontal cortex (vmPFC) functional...
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| Veröffentlicht in: | Nature neuroscience 2012-12, Vol.15 (12), p.1736-1741 |
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| creator | Burghy, Cory A Stodola, Diane E Ruttle, Paula L Molloy, Erin K Armstrong, Jeffrey M Oler, Jonathan A Fox, Michelle E Hayes, Andrea S Kalin, Ned H Essex, Marilyn J Davidson, Richard J Birn, Rasmus M |
| description | The authors assessed the contributions of early life stress (ELS) and childhood cortisol levels to adolescent resting-state functional connectivity. In females, ELS predicted increased cortisol levels in childhood, which predicted decreased amygdala-ventromedial prefrontal cortex (vmPFC) functional connectivity. Amygdala-vmPFC connectivity was inversely correlated with anxious sympotms and positively correlated with depressive symptoms.
Early life stress (ELS) and function of the hypothalamic-pituitary-adrenal axis predict later psychopathology. Animal studies and cross-sectional human studies suggest that this process might operate through amygdala–ventromedial prefrontal cortex (vmPFC) circuitry implicated in the regulation of emotion. Here we prospectively investigated the roles of ELS and childhood basal cortisol amounts in the development of adolescent resting-state functional connectivity (rs-FC), assessed by functional connectivity magnetic resonance imaging (fcMRI), in the amygdala-PFC circuit. In females only, greater ELS predicted increased childhood cortisol levels, which predicted decreased amygdala-vmPFC rs-FC 14 years later. For females, adolescent amygdala-vmPFC functional connectivity was inversely correlated with concurrent anxiety symptoms but positively associated with depressive symptoms, suggesting differing pathways from childhood cortisol levels function through adolescent amygdala-vmPFC functional connectivity to anxiety and depression. These data highlight that, for females, the effects of ELS and early HPA-axis function may be detected much later in the intrinsic processing of emotion-related brain circuits. |
| doi_str_mv | 10.1038/nn.3257 |
| format | Article |
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Early life stress (ELS) and function of the hypothalamic-pituitary-adrenal axis predict later psychopathology. Animal studies and cross-sectional human studies suggest that this process might operate through amygdala–ventromedial prefrontal cortex (vmPFC) circuitry implicated in the regulation of emotion. Here we prospectively investigated the roles of ELS and childhood basal cortisol amounts in the development of adolescent resting-state functional connectivity (rs-FC), assessed by functional connectivity magnetic resonance imaging (fcMRI), in the amygdala-PFC circuit. In females only, greater ELS predicted increased childhood cortisol levels, which predicted decreased amygdala-vmPFC rs-FC 14 years later. For females, adolescent amygdala-vmPFC functional connectivity was inversely correlated with concurrent anxiety symptoms but positively associated with depressive symptoms, suggesting differing pathways from childhood cortisol levels function through adolescent amygdala-vmPFC functional connectivity to anxiety and depression. These data highlight that, for females, the effects of ELS and early HPA-axis function may be detected much later in the intrinsic processing of emotion-related brain circuits.</description><identifier>ISSN: 1097-6256</identifier><identifier>EISSN: 1546-1726</identifier><identifier>DOI: 10.1038/nn.3257</identifier><identifier>PMID: 23143517</identifier><identifier>CODEN: NANEFN</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>631/136 ; 631/378/1457/1284 ; 631/378/1457/1945 ; 631/477 ; Adolescent ; Adolescent Behavior - physiology ; Adolescent Behavior - psychology ; Amygdala (Brain) ; Amygdala - growth & development ; Animal Genetics and Genomics ; Anxiety ; Anxiety - epidemiology ; Anxiety - metabolism ; Anxiety - psychology ; Behavioral Sciences ; Biological Techniques ; Biomedicine ; Child development ; Demographic aspects ; Depression - epidemiology ; Depression - metabolism ; Depression - psychology ; Depression, Mental ; Emotional regulation ; Female ; Hormones ; Humans ; Hydrocortisone - metabolism ; Male ; Neural Pathways - growth & development ; Neurobiology ; Neurosciences ; Physiological aspects ; Prefrontal cortex ; Prefrontal Cortex - growth & development ; Prospective Studies ; Psychological aspects ; Psychology, Pathological ; Psychopathology ; Stress ; Stress, Psychological - epidemiology ; Stress, Psychological - metabolism ; Stress, Psychological - psychology ; Teenagers ; Youth</subject><ispartof>Nature neuroscience, 2012-12, Vol.15 (12), p.1736-1741</ispartof><rights>Springer Nature America, Inc. 2012</rights><rights>COPYRIGHT 2012 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Dec 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c663t-911340fe739306bd4926e7d073ddea40d2c4f43d29fbdb7f693e5e3dba6c920a3</citedby><cites>FETCH-LOGICAL-c663t-911340fe739306bd4926e7d073ddea40d2c4f43d29fbdb7f693e5e3dba6c920a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/nn.3257$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/nn.3257$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23143517$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Burghy, Cory A</creatorcontrib><creatorcontrib>Stodola, Diane E</creatorcontrib><creatorcontrib>Ruttle, Paula L</creatorcontrib><creatorcontrib>Molloy, Erin K</creatorcontrib><creatorcontrib>Armstrong, Jeffrey M</creatorcontrib><creatorcontrib>Oler, Jonathan A</creatorcontrib><creatorcontrib>Fox, Michelle E</creatorcontrib><creatorcontrib>Hayes, Andrea S</creatorcontrib><creatorcontrib>Kalin, Ned H</creatorcontrib><creatorcontrib>Essex, Marilyn J</creatorcontrib><creatorcontrib>Davidson, Richard J</creatorcontrib><creatorcontrib>Birn, Rasmus M</creatorcontrib><title>Developmental pathways to amygdala-prefrontal function and internalizing symptoms in adolescence</title><title>Nature neuroscience</title><addtitle>Nat Neurosci</addtitle><addtitle>Nat Neurosci</addtitle><description>The authors assessed the contributions of early life stress (ELS) and childhood cortisol levels to adolescent resting-state functional connectivity. In females, ELS predicted increased cortisol levels in childhood, which predicted decreased amygdala-ventromedial prefrontal cortex (vmPFC) functional connectivity. Amygdala-vmPFC connectivity was inversely correlated with anxious sympotms and positively correlated with depressive symptoms.
Early life stress (ELS) and function of the hypothalamic-pituitary-adrenal axis predict later psychopathology. Animal studies and cross-sectional human studies suggest that this process might operate through amygdala–ventromedial prefrontal cortex (vmPFC) circuitry implicated in the regulation of emotion. Here we prospectively investigated the roles of ELS and childhood basal cortisol amounts in the development of adolescent resting-state functional connectivity (rs-FC), assessed by functional connectivity magnetic resonance imaging (fcMRI), in the amygdala-PFC circuit. In females only, greater ELS predicted increased childhood cortisol levels, which predicted decreased amygdala-vmPFC rs-FC 14 years later. For females, adolescent amygdala-vmPFC functional connectivity was inversely correlated with concurrent anxiety symptoms but positively associated with depressive symptoms, suggesting differing pathways from childhood cortisol levels function through adolescent amygdala-vmPFC functional connectivity to anxiety and depression. These data highlight that, for females, the effects of ELS and early HPA-axis function may be detected much later in the intrinsic processing of emotion-related brain circuits.</description><subject>631/136</subject><subject>631/378/1457/1284</subject><subject>631/378/1457/1945</subject><subject>631/477</subject><subject>Adolescent</subject><subject>Adolescent Behavior - physiology</subject><subject>Adolescent Behavior - psychology</subject><subject>Amygdala (Brain)</subject><subject>Amygdala - growth & development</subject><subject>Animal Genetics and Genomics</subject><subject>Anxiety</subject><subject>Anxiety - epidemiology</subject><subject>Anxiety - metabolism</subject><subject>Anxiety - psychology</subject><subject>Behavioral Sciences</subject><subject>Biological Techniques</subject><subject>Biomedicine</subject><subject>Child development</subject><subject>Demographic aspects</subject><subject>Depression - epidemiology</subject><subject>Depression - metabolism</subject><subject>Depression - 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In females, ELS predicted increased cortisol levels in childhood, which predicted decreased amygdala-ventromedial prefrontal cortex (vmPFC) functional connectivity. Amygdala-vmPFC connectivity was inversely correlated with anxious sympotms and positively correlated with depressive symptoms.
Early life stress (ELS) and function of the hypothalamic-pituitary-adrenal axis predict later psychopathology. Animal studies and cross-sectional human studies suggest that this process might operate through amygdala–ventromedial prefrontal cortex (vmPFC) circuitry implicated in the regulation of emotion. Here we prospectively investigated the roles of ELS and childhood basal cortisol amounts in the development of adolescent resting-state functional connectivity (rs-FC), assessed by functional connectivity magnetic resonance imaging (fcMRI), in the amygdala-PFC circuit. In females only, greater ELS predicted increased childhood cortisol levels, which predicted decreased amygdala-vmPFC rs-FC 14 years later. For females, adolescent amygdala-vmPFC functional connectivity was inversely correlated with concurrent anxiety symptoms but positively associated with depressive symptoms, suggesting differing pathways from childhood cortisol levels function through adolescent amygdala-vmPFC functional connectivity to anxiety and depression. These data highlight that, for females, the effects of ELS and early HPA-axis function may be detected much later in the intrinsic processing of emotion-related brain circuits.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>23143517</pmid><doi>10.1038/nn.3257</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 631/136 631/378/1457/1284 631/378/1457/1945 631/477 Adolescent Adolescent Behavior - physiology Adolescent Behavior - psychology Amygdala (Brain) Amygdala - growth & development Animal Genetics and Genomics Anxiety Anxiety - epidemiology Anxiety - metabolism Anxiety - psychology Behavioral Sciences Biological Techniques Biomedicine Child development Demographic aspects Depression - epidemiology Depression - metabolism Depression - psychology Depression, Mental Emotional regulation Female Hormones Humans Hydrocortisone - metabolism Male Neural Pathways - growth & development Neurobiology Neurosciences Physiological aspects Prefrontal cortex Prefrontal Cortex - growth & development Prospective Studies Psychological aspects Psychology, Pathological Psychopathology Stress Stress, Psychological - epidemiology Stress, Psychological - metabolism Stress, Psychological - psychology Teenagers Youth |
| title | Developmental pathways to amygdala-prefrontal function and internalizing symptoms in adolescence |
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