The spliceosome: a flexible, reversible macromolecular machine

With more than a hundred individual RNA and protein parts and a highly dynamic assembly and disassembly pathway, the spliceosome is arguably the most complicated macromolecular machine in the eukaryotic cell. This complexity has made kinetic and mechanistic analysis of splicing incredibly challengin...

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Veröffentlicht in:	Trends in biochemical sciences (Amsterdam. Regular ed.) 2012-05, Vol.37 (5), p.179-188
Hauptverfasser:	Hoskins, Aaron A., Moore, Melissa J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence dynamics eukaryotic cells Humans Models, Genetic RNA RNA Precursors - genetics RNA Precursors - metabolism RNA Splicing RNA, Messenger - genetics RNA, Messenger - metabolism spliceosomes Spliceosomes - genetics Spliceosomes - metabolism
Online-Zugang:	Volltext
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