Transforming Growth Factor Beta Receptor I Inhibitor Sensitizes Drug-resistant Pancreatic Cancer Cells to Gemcitabine

Resistance to gemcitabine is a major obstacle in the treatment of advanced pancreatic cancer. Previous exploration of protein kinase inhibitors demonstrated that blocking transforming growth factor-β (TGFβ) signal enhances the efficacy of gemcitabine in pancreatic cancer cells. We analyzed the cell...

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Veröffentlicht in:	Anticancer research 2012-03, Vol.32 (3), p.799-806
Hauptverfasser:	YEON JEONG KIM, JAE SEOK HWANG, YOUNG BIN HONG, BAE, Insoo, SEONG, Yeon-Sun
Format:	Artikel
Sprache:	eng
Schlagworte:	Antimetabolites, Antineoplastic Biological and medical sciences Cell Line, Tumor Deoxycytidine - analogs & derivatives Deoxycytidine - pharmacology Gastroenterology. Liver. Pancreas. Abdomen Humans Imidazoles - pharmacology Liver. Biliary tract. Portal circulation. Exocrine pancreas Medical sciences Pancreatic Neoplasms - pathology Protein-Serine-Threonine Kinases - antagonists & inhibitors Quinoxalines - pharmacology Receptors, Transforming Growth Factor beta - antagonists & inhibitors Tumors
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