Development and characterization of a new Parkinson's disease model resulting from impaired autophagy

Parkinson's disease (PD) is a progressive neurodegenerative disease caused by the interaction of genetic and environmental factors. However, the etiology of PD remains largely unknown. Macroautophagy is known to play an essential role in the degradation of abnormal proteins and organelles. Furt...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of neuroscience 2012-11, Vol.32 (46), p.16503-16509
Hauptverfasser:	Ahmed, Ishrat, Liang, Yideng, Schools, Sabitha, Dawson, Valina L, Dawson, Ted M, Savitt, Joseph M
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Synuclein - metabolism Animals Autophagy - physiology Autophagy-Related Protein 7 Blotting, Western Brief Communications Cell Count Chromatography, High Pressure Liquid Disease Models, Animal Dopamine - metabolism Dopaminergic Neurons - physiology Dynactin Complex Electrochemistry Gene Deletion Immunohistochemistry Mice Mice, Knockout Microtubule-Associated Proteins - genetics Microtubule-Associated Proteins - metabolism Neostriatum - metabolism Neurotransmitter Agents - metabolism Parkinson Disease - metabolism Parkinson Disease - pathology Polyubiquitin - metabolism Ubiquitin - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!