Arrested spermatogenesis and evidence for DNA damage in PTIP mutant testes

The differentiation of mature sperm from male germ cells requires both chromatin remodeling and compaction as well as DNA double stranded break repair of sister chromatids. We examined the function of PTIP, a protein implicated in both DNA repair and histone methylation, during spermatogenesis by us...

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Veröffentlicht in:	Developmental biology 2013-01, Vol.373 (1), p.64-71
Hauptverfasser:	Schwab, Kristopher R., Smith, Gary D., Dressler, Gregory R.
Format:	Artikel
Sprache:	eng
Schlagworte:	adults Animals Atrophy Blotting, Western Carrier Proteins - genetics chromatids chromatin Chromatin remodeling Compaction Data processing Differentiation DNA DNA damage DNA Damage - genetics DNA Primers - genetics DNA repair DNA Repair - genetics Gene Expression Profiling Genomic instability Genomic Instability - genetics Germ cells Histones Infertility Male males Meiosis Meiosis - genetics Meiosis - physiology Methylation Mice Microscopy, Fluorescence mutants Mutation Nuclear Proteins - genetics PTIP sister chromatids Sperm Spermatocytes Spermatogenesis Spermatogenesis - genetics spermatozoa Testes Testis - metabolism Testosterone - blood
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