Role of ATP binding and hydrolysis in assembly of MacAB-TolC macrolide transporter

Summary MacB is a founding member of the Macrolide Exporter family of transporters belonging to the ATP‐Binding Cassette superfamily. These proteins are broadly represented in genomes of both Gram‐positive and Gram‐negative bacteria and are implicated in virulence and protection against antibiotics...

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Veröffentlicht in:	Molecular microbiology 2012-12, Vol.86 (5), p.1132-1143
Hauptverfasser:	Lu, Shuo, Zgurskaya, Helen I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine triphosphatase Adenosine Triphosphatases - genetics Adenosine Triphosphatases - metabolism Adenosine Triphosphate - metabolism ATP-Binding Cassette Transporters - chemistry ATP-Binding Cassette Transporters - genetics ATP-Binding Cassette Transporters - metabolism Bacterial Outer Membrane Proteins - chemistry Bacterial Outer Membrane Proteins - genetics Bacterial Outer Membrane Proteins - metabolism Binding sites Biological and medical sciences Erythromycin - pharmacology Escherichia coli - drug effects Escherichia coli - genetics Escherichia coli - metabolism Escherichia coli Proteins - chemistry Escherichia coli Proteins - genetics Escherichia coli Proteins - metabolism Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Bacterial Gram-negative bacteria Hydrolysis Kinetics Macrolides - metabolism Macrolides - pharmacology Membrane Transport Proteins - chemistry Membrane Transport Proteins - genetics Membrane Transport Proteins - metabolism Membranes Microbial Sensitivity Tests Microbiology Mutation Oleandomycin - pharmacology Peptides Protein Binding Protein Conformation
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