Hepatitis c virus-specific t-cell-derived transforming growth factor beta is associated with slow hepatic fibrogenesis

Hepatitis C virus (HCV)‐specific immune effector responses can cause liver damage in chronic infection. Hepatic stellate cells (HSC) are the main effectors of liver fibrosis. TGFβ, produced by HCV‐specific CD8+ T cells, is a key regulatory cytokine modulating HCV‐specific effector T cells. Here we s...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2012-12, Vol.56 (6), p.2094-2105
Hauptverfasser:	Li, Shaoyong, Vriend, Lianne E.M., Nasser, Imad A., Popov, Yury, Afdhal, Nezam H., Koziel, Margaret J., Schuppan, Detlef, Exley, Mark A., Alatrakchi, Nadia
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Biological and medical sciences CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism Collagen Type I - genetics Cross-Sectional Studies Cytokines Disease Progression Female Gastroenterology. Liver. Pancreas. Abdomen Gene Expression Hepacivirus - immunology Hepatic Stellate Cells - metabolism Hepatitis Hepatitis C Hepatitis C, Chronic - immunology Hepatitis C, Chronic - metabolism Hepatitis C, Chronic - pathology Hepatology Humans Interferon-gamma - metabolism Interleukin-10 - metabolism Liver - immunology Liver - metabolism Liver cirrhosis Liver Cirrhosis - immunology Liver Cirrhosis - metabolism Liver Cirrhosis - pathology Liver. Biliary tract. Portal circulation. Exocrine pancreas Lymphocytes Male Matrix Metalloproteinase 1 - genetics Medical sciences Middle Aged T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - metabolism Transforming Growth Factor beta - metabolism Viral Core Proteins - immunology
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