Differential Roles for "Nr4a1" and "Nr4a2" in Object Location vs. Object Recognition Long-Term Memory
"Nr4a1" and "Nr4a2" are transcription factors and immediate early genes belonging to the nuclear receptor Nr4a family. In this study, we examine their role in long-term memory formation for object location and object recognition. Using siRNA to block expression of either "Nr...
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| Veröffentlicht in: | Learning & memory (Cold Spring Harbor, N.Y.) N.Y.), 2012-12, Vol.19 (12), p.588-592 |
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| container_title | Learning & memory (Cold Spring Harbor, N.Y.) |
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| creator | McNulty, Susan E Barrett, Ruth M Vogel-Ciernia, Annie Malvaez, Melissa Hernandez, Nicole Davatolhagh, M. Felicia Matheos, Dina P Schiffman, Aaron Wood, Marcelo A |
| description | "Nr4a1" and "Nr4a2" are transcription factors and immediate early genes belonging to the nuclear receptor Nr4a family. In this study, we examine their role in long-term memory formation for object location and object recognition. Using siRNA to block expression of either "Nr4a1" or "Nr4a2", we found that "Nr4a2" is necessary for both long-term memory for object location and object recognition. In contrast, "Nr4a1" appears to be necessary only for object location. Indeed, their roles in these different types of long-term memory may be dependent on their expression in the brain, as NR4A2 was found to be expressed in hippocampal neurons (associated with object location memory) as well as in the insular and perirhinal cortex (associated with object recognition memory), whereas NR4A1 showed minimal neuronal expression in these cortical areas. These results begin to elucidate how NR4A1 and NR4A2 differentially contribute to object location versus object recognition memory. |
| doi_str_mv | 10.1101/lm.026385.112 |
| format | Article |
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Indeed, their roles in these different types of long-term memory may be dependent on their expression in the brain, as NR4A2 was found to be expressed in hippocampal neurons (associated with object location memory) as well as in the insular and perirhinal cortex (associated with object recognition memory), whereas NR4A1 showed minimal neuronal expression in these cortical areas. These results begin to elucidate how NR4A1 and NR4A2 differentially contribute to object location versus object recognition memory.</description><identifier>ISSN: 1072-0502</identifier><identifier>ISSN: 1549-5485</identifier><identifier>EISSN: 1549-5485</identifier><identifier>DOI: 10.1101/lm.026385.112</identifier><identifier>PMID: 23161447</identifier><language>eng</language><publisher>United States: Cold Spring Harbor Laboratory Press</publisher><subject>Animals ; Brain ; Brief Communication ; Cerebral Cortex - drug effects ; Cerebral Cortex - metabolism ; Gene Expression Regulation - drug effects ; Gene Expression Regulation - physiology ; Genetics ; Geographic Location ; Hippocampus - cytology ; Hippocampus - drug effects ; Hippocampus - metabolism ; Learning ; Long Term Memory ; Male ; Memory, Long-Term - drug effects ; Memory, Long-Term - radiation effects ; Mice ; Mice, Inbred C57BL ; Neurons - drug effects ; Neurons - metabolism ; Nuclear Receptor Subfamily 4, Group A, Member 1 - genetics ; Nuclear Receptor Subfamily 4, Group A, Member 1 - metabolism ; Nuclear Receptor Subfamily 4, Group A, Member 2 - genetics ; Nuclear Receptor Subfamily 4, Group A, Member 2 - metabolism ; Phosphopyruvate Hydratase - metabolism ; Recognition (Psychology) ; Recognition (Psychology) - drug effects ; Recognition (Psychology) - physiology ; RNA, Messenger - metabolism ; RNA, Small Interfering - pharmacology ; Time Factors</subject><ispartof>Learning & memory (Cold Spring Harbor, N.Y.), 2012-12, Vol.19 (12), p.588-592</ispartof><rights>2012 Cold Spring Harbor Laboratory Press 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c508t-137c4f9e8e7ed76c5348bf82b405ded3b074dfbd8ac9c66d494e7778419322743</citedby><cites>FETCH-LOGICAL-c508t-137c4f9e8e7ed76c5348bf82b405ded3b074dfbd8ac9c66d494e7778419322743</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3506974/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3506974/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttp://eric.ed.gov/ERICWebPortal/detail?accno=EJ1000146$$DView record in ERIC$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23161447$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>McNulty, Susan E</creatorcontrib><creatorcontrib>Barrett, Ruth M</creatorcontrib><creatorcontrib>Vogel-Ciernia, Annie</creatorcontrib><creatorcontrib>Malvaez, Melissa</creatorcontrib><creatorcontrib>Hernandez, Nicole</creatorcontrib><creatorcontrib>Davatolhagh, M. 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Indeed, their roles in these different types of long-term memory may be dependent on their expression in the brain, as NR4A2 was found to be expressed in hippocampal neurons (associated with object location memory) as well as in the insular and perirhinal cortex (associated with object recognition memory), whereas NR4A1 showed minimal neuronal expression in these cortical areas. These results begin to elucidate how NR4A1 and NR4A2 differentially contribute to object location versus object recognition memory.</description><subject>Animals</subject><subject>Brain</subject><subject>Brief Communication</subject><subject>Cerebral Cortex - drug effects</subject><subject>Cerebral Cortex - metabolism</subject><subject>Gene Expression Regulation - drug effects</subject><subject>Gene Expression Regulation - physiology</subject><subject>Genetics</subject><subject>Geographic Location</subject><subject>Hippocampus - cytology</subject><subject>Hippocampus - drug effects</subject><subject>Hippocampus - metabolism</subject><subject>Learning</subject><subject>Long Term Memory</subject><subject>Male</subject><subject>Memory, Long-Term - drug effects</subject><subject>Memory, Long-Term - radiation effects</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Neurons - drug effects</subject><subject>Neurons - metabolism</subject><subject>Nuclear Receptor Subfamily 4, Group A, Member 1 - genetics</subject><subject>Nuclear Receptor Subfamily 4, Group A, Member 1 - metabolism</subject><subject>Nuclear Receptor Subfamily 4, Group A, Member 2 - genetics</subject><subject>Nuclear Receptor Subfamily 4, Group A, Member 2 - metabolism</subject><subject>Phosphopyruvate Hydratase - metabolism</subject><subject>Recognition (Psychology)</subject><subject>Recognition (Psychology) - drug effects</subject><subject>Recognition (Psychology) - physiology</subject><subject>RNA, Messenger - metabolism</subject><subject>RNA, Small Interfering - pharmacology</subject><subject>Time Factors</subject><issn>1072-0502</issn><issn>1549-5485</issn><issn>1549-5485</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkctLxDAQxoMovo8elbAnL13zTnsRxLesCqLnkKbTNdI2mnQF_3ur1UVP8_rxzQwfQnuUTCkl9Khpp4QpnsuhZCtok0pRZFLkcnXIiWYZkYRtoK2UXgghWgu6jjYYp4oKoTcRnPm6hghd722DH0IDCdch4sldFJZOsO2qMWcT7Dt8X76A6_EsONv70OH3NP3tPYAL885_t2ehm2ePEFt8C22IHztorbZNgt2fuI2eLs4fT6-y2f3l9enJLHOS5H1GuXaiLiAHDZVWTnKRl3XOSkFkBRUviRZVXVa5dYVTqhKFAK11LmjBGdOCb6PjUfd1UbZQueGtaBvzGn1r44cJ1pv_k84_m3l4N1wSVXwLHP4IxPC2gNSb1icHTWM7CItkqNKcF4oWckCzEXUxpBShXq6hxHxZY5rWjNYMJRv4g7-3LelfLwZgfwQgerccn9_QwTcqFP8EHcWSBg</recordid><startdate>20121201</startdate><enddate>20121201</enddate><creator>McNulty, Susan E</creator><creator>Barrett, Ruth M</creator><creator>Vogel-Ciernia, Annie</creator><creator>Malvaez, Melissa</creator><creator>Hernandez, Nicole</creator><creator>Davatolhagh, M. 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Felicia ; Matheos, Dina P ; Schiffman, Aaron ; Wood, Marcelo A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c508t-137c4f9e8e7ed76c5348bf82b405ded3b074dfbd8ac9c66d494e7778419322743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animals</topic><topic>Brain</topic><topic>Brief Communication</topic><topic>Cerebral Cortex - drug effects</topic><topic>Cerebral Cortex - metabolism</topic><topic>Gene Expression Regulation - drug effects</topic><topic>Gene Expression Regulation - physiology</topic><topic>Genetics</topic><topic>Geographic Location</topic><topic>Hippocampus - cytology</topic><topic>Hippocampus - drug effects</topic><topic>Hippocampus - metabolism</topic><topic>Learning</topic><topic>Long Term Memory</topic><topic>Male</topic><topic>Memory, Long-Term - drug effects</topic><topic>Memory, Long-Term - radiation effects</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Neurons - drug effects</topic><topic>Neurons - metabolism</topic><topic>Nuclear Receptor Subfamily 4, Group A, Member 1 - genetics</topic><topic>Nuclear Receptor Subfamily 4, Group A, Member 1 - metabolism</topic><topic>Nuclear Receptor Subfamily 4, Group A, Member 2 - genetics</topic><topic>Nuclear Receptor Subfamily 4, Group A, Member 2 - metabolism</topic><topic>Phosphopyruvate Hydratase - metabolism</topic><topic>Recognition (Psychology)</topic><topic>Recognition (Psychology) - drug effects</topic><topic>Recognition (Psychology) - physiology</topic><topic>RNA, Messenger - metabolism</topic><topic>RNA, Small Interfering - pharmacology</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>McNulty, Susan E</creatorcontrib><creatorcontrib>Barrett, Ruth M</creatorcontrib><creatorcontrib>Vogel-Ciernia, Annie</creatorcontrib><creatorcontrib>Malvaez, Melissa</creatorcontrib><creatorcontrib>Hernandez, Nicole</creatorcontrib><creatorcontrib>Davatolhagh, M. 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Felicia</au><au>Matheos, Dina P</au><au>Schiffman, Aaron</au><au>Wood, Marcelo A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><ericid>EJ1000146</ericid><atitle>Differential Roles for "Nr4a1" and "Nr4a2" in Object Location vs. Object Recognition Long-Term Memory</atitle><jtitle>Learning & memory (Cold Spring Harbor, N.Y.)</jtitle><addtitle>Learn Mem</addtitle><date>2012-12-01</date><risdate>2012</risdate><volume>19</volume><issue>12</issue><spage>588</spage><epage>592</epage><pages>588-592</pages><issn>1072-0502</issn><issn>1549-5485</issn><eissn>1549-5485</eissn><abstract>"Nr4a1" and "Nr4a2" are transcription factors and immediate early genes belonging to the nuclear receptor Nr4a family. In this study, we examine their role in long-term memory formation for object location and object recognition. Using siRNA to block expression of either "Nr4a1" or "Nr4a2", we found that "Nr4a2" is necessary for both long-term memory for object location and object recognition. In contrast, "Nr4a1" appears to be necessary only for object location. Indeed, their roles in these different types of long-term memory may be dependent on their expression in the brain, as NR4A2 was found to be expressed in hippocampal neurons (associated with object location memory) as well as in the insular and perirhinal cortex (associated with object recognition memory), whereas NR4A1 showed minimal neuronal expression in these cortical areas. These results begin to elucidate how NR4A1 and NR4A2 differentially contribute to object location versus object recognition memory.</abstract><cop>United States</cop><pub>Cold Spring Harbor Laboratory Press</pub><pmid>23161447</pmid><doi>10.1101/lm.026385.112</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Learning & memory (Cold Spring Harbor, N.Y.), 2012-12, Vol.19 (12), p.588-592 |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Animals Brain Brief Communication Cerebral Cortex - drug effects Cerebral Cortex - metabolism Gene Expression Regulation - drug effects Gene Expression Regulation - physiology Genetics Geographic Location Hippocampus - cytology Hippocampus - drug effects Hippocampus - metabolism Learning Long Term Memory Male Memory, Long-Term - drug effects Memory, Long-Term - radiation effects Mice Mice, Inbred C57BL Neurons - drug effects Neurons - metabolism Nuclear Receptor Subfamily 4, Group A, Member 1 - genetics Nuclear Receptor Subfamily 4, Group A, Member 1 - metabolism Nuclear Receptor Subfamily 4, Group A, Member 2 - genetics Nuclear Receptor Subfamily 4, Group A, Member 2 - metabolism Phosphopyruvate Hydratase - metabolism Recognition (Psychology) Recognition (Psychology) - drug effects Recognition (Psychology) - physiology RNA, Messenger - metabolism RNA, Small Interfering - pharmacology Time Factors |
| title | Differential Roles for "Nr4a1" and "Nr4a2" in Object Location vs. Object Recognition Long-Term Memory |
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