MACC1: A potential molecule associated with pancreatic cancer metastasis and chemoresistance
It has been suggested that the newly identified metastasis-associated in colon cancer-1 (MACC1) oncogene is involved in the progression and metastasis of cancer. Several studies have indicated that MACC1 has potential as a novel biomarker. In this study, we aimed to investigate the functions and ser...
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| Veröffentlicht in: | Oncology letters 2012-10, Vol.4 (4), p.783-791 |
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| container_title | Oncology letters |
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| creator | WANG, GANG KANG, MU-XING LU, WEN-JIE CHEN, YING ZHANG, BO WU, YU-LIAN |
| description | It has been suggested that the newly identified metastasis-associated in colon cancer-1 (MACC1) oncogene is involved in the progression and metastasis of cancer. Several studies have indicated that MACC1 has potential as a novel biomarker. In this study, we aimed to investigate the functions and serum expression levels of MACC1 in pancreatic cancer patients. Blood serum samples from 60 cancer patients and 49 controls were analyzed for serum MACC1 by ELISA. The results revealed that high expression levels of MACC1 were correlated with lymph node metastasis, distant metastasis and a later TNM stage. Inhibition of MACC1 by siRNAs significantly suppressed pancreatic cancer cell proliferation and migration. Furthermore, it was found that the downregulation of MACC1 sensitized pancreatic cancer cells to gemcitabine treatment through the inhibition of the Ras/ERK signaling pathway. Our findings suggest that MACC1 may aid in the diagnosis of pancreatic cancer and serve as a potential therapeutic target. |
| doi_str_mv | 10.3892/ol.2012.784 |
| format | Article |
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Several studies have indicated that MACC1 has potential as a novel biomarker. In this study, we aimed to investigate the functions and serum expression levels of MACC1 in pancreatic cancer patients. Blood serum samples from 60 cancer patients and 49 controls were analyzed for serum MACC1 by ELISA. The results revealed that high expression levels of MACC1 were correlated with lymph node metastasis, distant metastasis and a later TNM stage. Inhibition of MACC1 by siRNAs significantly suppressed pancreatic cancer cell proliferation and migration. Furthermore, it was found that the downregulation of MACC1 sensitized pancreatic cancer cells to gemcitabine treatment through the inhibition of the Ras/ERK signaling pathway. Our findings suggest that MACC1 may aid in the diagnosis of pancreatic cancer and serve as a potential therapeutic target.</description><identifier>ISSN: 1792-1074</identifier><identifier>EISSN: 1792-1082</identifier><identifier>DOI: 10.3892/ol.2012.784</identifier><identifier>PMID: 23205101</identifier><language>eng</language><publisher>Greece: D.A. Spandidos</publisher><subject>Apoptosis ; Cell culture ; chemoresistance ; Colorectal cancer ; Drug resistance ; epithelial-mesenchymal transition ; Gene expression ; Genotype & phenotype ; Kinases ; Metastasis ; metastasis-associated in colon cancer-1 ; Mortality ; Oncology ; Pancreatic cancer ; Studies ; Tumors</subject><ispartof>Oncology letters, 2012-10, Vol.4 (4), p.783-791</ispartof><rights>Copyright © 2012, Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2012</rights><rights>Copyright © 2012, Spandidos Publications 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c440t-1942e36ce41cbb5d775ec069e519aabad5996739810499cb973e8f981675a94e3</citedby><cites>FETCH-LOGICAL-c440t-1942e36ce41cbb5d775ec069e519aabad5996739810499cb973e8f981675a94e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3506703/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3506703/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,5555,27903,27904,53770,53772</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23205101$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>WANG, GANG</creatorcontrib><creatorcontrib>KANG, MU-XING</creatorcontrib><creatorcontrib>LU, WEN-JIE</creatorcontrib><creatorcontrib>CHEN, YING</creatorcontrib><creatorcontrib>ZHANG, BO</creatorcontrib><creatorcontrib>WU, YU-LIAN</creatorcontrib><title>MACC1: A potential molecule associated with pancreatic cancer metastasis and chemoresistance</title><title>Oncology letters</title><addtitle>Oncol Lett</addtitle><description>It has been suggested that the newly identified metastasis-associated in colon cancer-1 (MACC1) oncogene is involved in the progression and metastasis of cancer. Several studies have indicated that MACC1 has potential as a novel biomarker. In this study, we aimed to investigate the functions and serum expression levels of MACC1 in pancreatic cancer patients. Blood serum samples from 60 cancer patients and 49 controls were analyzed for serum MACC1 by ELISA. The results revealed that high expression levels of MACC1 were correlated with lymph node metastasis, distant metastasis and a later TNM stage. Inhibition of MACC1 by siRNAs significantly suppressed pancreatic cancer cell proliferation and migration. Furthermore, it was found that the downregulation of MACC1 sensitized pancreatic cancer cells to gemcitabine treatment through the inhibition of the Ras/ERK signaling pathway. Our findings suggest that MACC1 may aid in the diagnosis of pancreatic cancer and serve as a potential therapeutic target.</description><subject>Apoptosis</subject><subject>Cell culture</subject><subject>chemoresistance</subject><subject>Colorectal cancer</subject><subject>Drug resistance</subject><subject>epithelial-mesenchymal transition</subject><subject>Gene expression</subject><subject>Genotype & phenotype</subject><subject>Kinases</subject><subject>Metastasis</subject><subject>metastasis-associated in colon cancer-1</subject><subject>Mortality</subject><subject>Oncology</subject><subject>Pancreatic cancer</subject><subject>Studies</subject><subject>Tumors</subject><issn>1792-1074</issn><issn>1792-1082</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpdkVuLFDEQhRtR3GXdJ98lIIiw9Jj7xQdhGFwVVnzRNyGk0zVOlnRnTNKK_96Ms46XUJAq6uNQh9N1jwleMW3oixRXFBO6Uprf686JMrQnWNP7p17xs-6ylFvcnpBEa_mwO6OMYkEwOe8-v19vNuQlWqN9qjDX4CKaUgS_RECulOSDqzCi76Hu0N7NPoOrwSPfWshogupKq1CQm0fkdzClDG2sh_2j7sHWxQKXd_9F9-n69cfN2_7mw5t3m_VN7znHtSeGU2DSAyd-GMSolACPpQFBjHODG4UxUjGjCebG-MEoBnrbRqmEMxzYRffqqLtfhglG33xkF-0-h8nlHza5YP_dzGFnv6RvlgksFWZN4PmdQE5fFyjVTqF4iNHNkJZiiaZSSC7YAX36H3qbljw3e5YYRiVRlOhGXR0pn1MpGbanYwi2h-BsivYQnG3BNfrJ3_ef2N8xNeDZESgtgjGMqfwxF3vMf5XSjP0EegKf8Q</recordid><startdate>20121001</startdate><enddate>20121001</enddate><creator>WANG, GANG</creator><creator>KANG, MU-XING</creator><creator>LU, WEN-JIE</creator><creator>CHEN, YING</creator><creator>ZHANG, BO</creator><creator>WU, YU-LIAN</creator><general>D.A. Spandidos</general><general>Spandidos Publications UK Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20121001</creationdate><title>MACC1: A potential molecule associated with pancreatic cancer metastasis and chemoresistance</title><author>WANG, GANG ; KANG, MU-XING ; LU, WEN-JIE ; CHEN, YING ; ZHANG, BO ; WU, YU-LIAN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c440t-1942e36ce41cbb5d775ec069e519aabad5996739810499cb973e8f981675a94e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Apoptosis</topic><topic>Cell culture</topic><topic>chemoresistance</topic><topic>Colorectal cancer</topic><topic>Drug resistance</topic><topic>epithelial-mesenchymal transition</topic><topic>Gene expression</topic><topic>Genotype & phenotype</topic><topic>Kinases</topic><topic>Metastasis</topic><topic>metastasis-associated in colon cancer-1</topic><topic>Mortality</topic><topic>Oncology</topic><topic>Pancreatic cancer</topic><topic>Studies</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>WANG, GANG</creatorcontrib><creatorcontrib>KANG, MU-XING</creatorcontrib><creatorcontrib>LU, WEN-JIE</creatorcontrib><creatorcontrib>CHEN, YING</creatorcontrib><creatorcontrib>ZHANG, BO</creatorcontrib><creatorcontrib>WU, YU-LIAN</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Oncology letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>WANG, GANG</au><au>KANG, MU-XING</au><au>LU, WEN-JIE</au><au>CHEN, YING</au><au>ZHANG, BO</au><au>WU, YU-LIAN</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MACC1: A potential molecule associated with pancreatic cancer metastasis and chemoresistance</atitle><jtitle>Oncology letters</jtitle><addtitle>Oncol Lett</addtitle><date>2012-10-01</date><risdate>2012</risdate><volume>4</volume><issue>4</issue><spage>783</spage><epage>791</epage><pages>783-791</pages><issn>1792-1074</issn><eissn>1792-1082</eissn><abstract>It has been suggested that the newly identified metastasis-associated in colon cancer-1 (MACC1) oncogene is involved in the progression and metastasis of cancer. Several studies have indicated that MACC1 has potential as a novel biomarker. In this study, we aimed to investigate the functions and serum expression levels of MACC1 in pancreatic cancer patients. Blood serum samples from 60 cancer patients and 49 controls were analyzed for serum MACC1 by ELISA. The results revealed that high expression levels of MACC1 were correlated with lymph node metastasis, distant metastasis and a later TNM stage. Inhibition of MACC1 by siRNAs significantly suppressed pancreatic cancer cell proliferation and migration. Furthermore, it was found that the downregulation of MACC1 sensitized pancreatic cancer cells to gemcitabine treatment through the inhibition of the Ras/ERK signaling pathway. Our findings suggest that MACC1 may aid in the diagnosis of pancreatic cancer and serve as a potential therapeutic target.</abstract><cop>Greece</cop><pub>D.A. 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| source | Spandidos Publications Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Apoptosis Cell culture chemoresistance Colorectal cancer Drug resistance epithelial-mesenchymal transition Gene expression Genotype & phenotype Kinases Metastasis metastasis-associated in colon cancer-1 Mortality Oncology Pancreatic cancer Studies Tumors |
| title | MACC1: A potential molecule associated with pancreatic cancer metastasis and chemoresistance |
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