Small RNA deep sequencing reveals a distinct miRNA signature released in exosomes from prion-infected neuronal cells

Prion diseases are transmissible neurodegenerative disorders affecting both humans and animals. The cellular prion protein, PrP(C), and the abnormal infectious form, PrP(Sc), are found associated with exosomes, which are small 50-130 nm vesicles released from cells. Exosomes also contain microRNAs (...

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Veröffentlicht in:	Nucleic acids research 2012-11, Vol.40 (21), p.10937-10949
Hauptverfasser:	Bellingham, Shayne A, Coleman, Bradley M, Hill, Andrew F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line Exosomes - metabolism High-Throughput Nucleotide Sequencing Hypothalamus - cytology Mice Mice, Inbred BALB C MicroRNAs - chemistry MicroRNAs - metabolism Neurons - metabolism Prions - physiology RNA RNA, Small Untranslated - chemistry RNA, Small Untranslated - metabolism Sequence Analysis, RNA Transcriptome
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