Evaluation of inhaled cidofovir as postexposure prophylactic in an aerosol rabbitpox model

► An aerosolized form of cidofovir protects rabbits from aerosol rabbitpox challenge. ► Aerosolized cidofovir provided comparable protection at a fraction of the IV therapeutic dosage. ► Aerosolized treatment significantly reduces lung viral load and corresponding pathology associated with RPX disea...

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Veröffentlicht in:	Antiviral research 2012-01, Vol.93 (1), p.204-208
Hauptverfasser:	Verreault, Daniel, Sivasubramani, Satheesh K., Talton, James D., Doyle, Lara A., Reddy, Joseph D., Killeen, Stephanie Z., Didier, Peter J., Marx, Preston A., Roy, Chad J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Inhalation Aerosol Aerosols Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Antiviral Agents - administration & dosage Biological and medical sciences Cell Line Cidofovir Cytosine - administration & dosage Cytosine - analogs & derivatives Disease Models, Animal Drug delivery Drug development Female Human viral diseases Infectious diseases Intravenous administration Lung Lung - pathology Lung - virology Male Medical sciences Organophosphonates - administration & dosage Pharmacology. Drug treatments Post-Exposure Prophylaxis Powder Poxvirus Prophylaxis Rabbitpox Rabbitpox virus Rabbits Reintroduction Smallpox Smallpox treatment Smallpox, monkey pox, tanapox Survival Tropical viral diseases Vaccinia - mortality Vaccinia - prevention & control Vaccinia - virology Vaccinia virus Viral diseases Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye
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