CLOCK deubiquitylation by USP8 inhibits CLK/CYC transcription in Drosophila

A conserved transcriptional feedback loop underlies animal circadian rhythms. In Drosophila, the transcription factors CLOCK (CLK) and CYCLE (CYC) activate the transcription of direct target genes like period (per) and timeless (tim). They encode the proteins PER and TIM, respectively, which repress...

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Veröffentlicht in:	Genes & development 2012-11, Vol.26 (22), p.2536-2549
Hauptverfasser:	Luo, Weifei, Li, Yue, Tang, Chih-Hang Anthony, Abruzzi, Katharine C, Rodriguez, Joseph, Pescatore, Stefan, Rosbash, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals ARNTL Transcription Factors - genetics ARNTL Transcription Factors - metabolism Circadian Rhythm - genetics CLOCK Proteins - genetics CLOCK Proteins - metabolism Drosophila melanogaster - enzymology Drosophila melanogaster - genetics Drosophila melanogaster - metabolism Drosophila melanogaster - physiology Drosophila Proteins - genetics Drosophila Proteins - metabolism Gene Expression Regulation Motor Activity - genetics Period Circadian Proteins - metabolism Protein Isoforms Research Paper RNA Interference Ubiquitin Thiolesterase - metabolism Ubiquitination
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