Characteristics of seizure frequency among Malaysian children diagnosed with structural-metabolic epilepsy
Seizure-free patients or substantial reduction in seizure frequency are the most important outcome measures in the management of epilepsy. The study aimed to evaluate the patterns of seizure frequency and its relationship with demographics, clinical characteristics, and outcomes. A retrospective coh...
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| Veröffentlicht in: | Journal of neurosciences in rural practice 2012-09, Vol.3 (3), p.244-250 |
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| creator | Salih, Muhannad Rm Bahari, Mohd Baldi Hassali, Mohamed Azmi Ahmad Shafie, Asrul Akmal Al-Lela, Omer Qutaiba B Abd, Arwa Y Ganesan, Vigneswari M |
| description | Seizure-free patients or substantial reduction in seizure frequency are the most important outcome measures in the management of epilepsy. The study aimed to evaluate the patterns of seizure frequency and its relationship with demographics, clinical characteristics, and outcomes.
A retrospective cohort study was conducted at the Pediatric Neurology Clinic, Hospital Pulau Pinang. Over a period of 6 months, the required data were extracted from the medical records using a pre-designed data collection form.
Seizure frequency showed no significant association with patient's demographics and clinical characteristic. However, significant reduction in seizure frequency from the baseline to the last follow-up visit was only seen in certain subgroups of patients including Malays, females, patients |
| doi_str_mv | 10.4103/0976-3147.102596 |
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A retrospective cohort study was conducted at the Pediatric Neurology Clinic, Hospital Pulau Pinang. Over a period of 6 months, the required data were extracted from the medical records using a pre-designed data collection form.
Seizure frequency showed no significant association with patient's demographics and clinical characteristic. However, significant reduction in seizure frequency from the baseline to the last follow-up visit was only seen in certain subgroups of patients including Malays, females, patients <4 years of age, patients with global developmental delay/intellectual disability, and patients with focal seizure. There was no significant association between seizure frequency and rate of adverse events. Polytherapy visits were associated with higher seizure frequency than monotherapy visits (27.97 ± 56.66, 10.94 ± 30.96 attack per month, respectively) (P < 0.001). There was a clear tendency to get antiepileptic drugs used at doses above the recommended range in polytherapy (8.4%) rather than in monotherapy (1.4%) visits (P < 0.001). A significant correlation was found between seizure frequency and number of visits per patient per year (r = 0.450, P < 0.001).
Among children with structural-metabolic epilepsy, Malays, females, patients <4 years of age, patients with global developmental delay/intellectual disability and patients manifested with focal seizure are more responsive antiepileptic drug therapy than the other subgroups of patients.</description><identifier>ISSN: 0976-3147</identifier><identifier>EISSN: 0976-3155</identifier><identifier>DOI: 10.4103/0976-3147.102596</identifier><identifier>PMID: 23188969</identifier><language>eng</language><publisher>United States: Medknow Publications and Media Pvt. Ltd</publisher><subject>Care and treatment ; Children & youth ; Convulsions & seizures ; Demographic aspects ; Diagnosis ; Epilepsy ; Epilepsy in children ; Health aspects ; Metabolic diseases ; Neurology ; Original ; Seizures (Medicine)</subject><ispartof>Journal of neurosciences in rural practice, 2012-09, Vol.3 (3), p.244-250</ispartof><rights>COPYRIGHT 2012 Medknow Publications and Media Pvt. Ltd.</rights><rights>Copyright Medknow Publications & Media Pvt Ltd Sep 2012</rights><rights>Copyright: © Journal of Neurosciences in Rural Practice 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c491t-7b73e3137e6b4510d862d29bcf760c31a287b0dfc2bee0c5e9e27fe7c0eaa9fe3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3505308/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3505308/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,729,782,786,887,27931,27932,53798,53800</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23188969$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Salih, Muhannad Rm</creatorcontrib><creatorcontrib>Bahari, Mohd Baldi</creatorcontrib><creatorcontrib>Hassali, Mohamed Azmi Ahmad</creatorcontrib><creatorcontrib>Shafie, Asrul Akmal</creatorcontrib><creatorcontrib>Al-Lela, Omer Qutaiba B</creatorcontrib><creatorcontrib>Abd, Arwa Y</creatorcontrib><creatorcontrib>Ganesan, Vigneswari M</creatorcontrib><title>Characteristics of seizure frequency among Malaysian children diagnosed with structural-metabolic epilepsy</title><title>Journal of neurosciences in rural practice</title><addtitle>J Neurosci Rural Pract</addtitle><description>Seizure-free patients or substantial reduction in seizure frequency are the most important outcome measures in the management of epilepsy. The study aimed to evaluate the patterns of seizure frequency and its relationship with demographics, clinical characteristics, and outcomes.
A retrospective cohort study was conducted at the Pediatric Neurology Clinic, Hospital Pulau Pinang. Over a period of 6 months, the required data were extracted from the medical records using a pre-designed data collection form.
Seizure frequency showed no significant association with patient's demographics and clinical characteristic. However, significant reduction in seizure frequency from the baseline to the last follow-up visit was only seen in certain subgroups of patients including Malays, females, patients <4 years of age, patients with global developmental delay/intellectual disability, and patients with focal seizure. There was no significant association between seizure frequency and rate of adverse events. Polytherapy visits were associated with higher seizure frequency than monotherapy visits (27.97 ± 56.66, 10.94 ± 30.96 attack per month, respectively) (P < 0.001). There was a clear tendency to get antiepileptic drugs used at doses above the recommended range in polytherapy (8.4%) rather than in monotherapy (1.4%) visits (P < 0.001). A significant correlation was found between seizure frequency and number of visits per patient per year (r = 0.450, P < 0.001).
Among children with structural-metabolic epilepsy, Malays, females, patients <4 years of age, patients with global developmental delay/intellectual disability and patients manifested with focal seizure are more responsive antiepileptic drug therapy than the other subgroups of patients.</description><subject>Care and treatment</subject><subject>Children & youth</subject><subject>Convulsions & seizures</subject><subject>Demographic aspects</subject><subject>Diagnosis</subject><subject>Epilepsy</subject><subject>Epilepsy in children</subject><subject>Health aspects</subject><subject>Metabolic diseases</subject><subject>Neurology</subject><subject>Original</subject><subject>Seizures (Medicine)</subject><issn>0976-3147</issn><issn>0976-3155</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptUk2PFCEU7BiNu1n37smQePHSIx9N01xMNhO_kjVe9Exo-jHDhIYRaM3462Uy4-ga4QB5VBXvVappnhO86ghmr7EUfctIJ1YEUy77R831ucT548u9E1fNbc47XBdjhGDxtLmijAyD7OV1s1tvddKmQHK5OJNRtCiD-7kkQDbBtwWCOSA9x7BBn7TXh-x0QGbr_JQgoMnpTYgZJvTDlS3KJS2mLEn7doaix-idQbB3Hvb58Kx5YrXPcHs-b5qv795-WX9o7z-__7i-u29NJ0lpxSgYMMIE9GPHCZ6Gnk5UjsaKHhtGNB3EiCdr6AiADQcJVFgQBoPW0gK7ad6cdPfLOMNkIJTakNonN-t0UFE79fAluK3axO-KccwZHqrAq7NAitWAXNTssgHvdYC4ZEUoxUJySWSFvvwHuotLCnU8RYioHg897_-gNtqDcsHG-q85iqo7hiXjouu6ilr9B1X3BLMzMYCtPj4k4BPBpJhzAnuZkWB1jIg6ZkAdM6BOEamUF397cyH8DgT7BQq7uFY</recordid><startdate>20120901</startdate><enddate>20120901</enddate><creator>Salih, Muhannad Rm</creator><creator>Bahari, Mohd Baldi</creator><creator>Hassali, Mohamed Azmi Ahmad</creator><creator>Shafie, Asrul Akmal</creator><creator>Al-Lela, Omer Qutaiba B</creator><creator>Abd, Arwa Y</creator><creator>Ganesan, Vigneswari M</creator><general>Medknow Publications and Media Pvt. 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The study aimed to evaluate the patterns of seizure frequency and its relationship with demographics, clinical characteristics, and outcomes.
A retrospective cohort study was conducted at the Pediatric Neurology Clinic, Hospital Pulau Pinang. Over a period of 6 months, the required data were extracted from the medical records using a pre-designed data collection form.
Seizure frequency showed no significant association with patient's demographics and clinical characteristic. However, significant reduction in seizure frequency from the baseline to the last follow-up visit was only seen in certain subgroups of patients including Malays, females, patients <4 years of age, patients with global developmental delay/intellectual disability, and patients with focal seizure. There was no significant association between seizure frequency and rate of adverse events. Polytherapy visits were associated with higher seizure frequency than monotherapy visits (27.97 ± 56.66, 10.94 ± 30.96 attack per month, respectively) (P < 0.001). There was a clear tendency to get antiepileptic drugs used at doses above the recommended range in polytherapy (8.4%) rather than in monotherapy (1.4%) visits (P < 0.001). A significant correlation was found between seizure frequency and number of visits per patient per year (r = 0.450, P < 0.001).
Among children with structural-metabolic epilepsy, Malays, females, patients <4 years of age, patients with global developmental delay/intellectual disability and patients manifested with focal seizure are more responsive antiepileptic drug therapy than the other subgroups of patients.</abstract><cop>United States</cop><pub>Medknow Publications and Media Pvt. Ltd</pub><pmid>23188969</pmid><doi>10.4103/0976-3147.102596</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of neurosciences in rural practice, 2012-09, Vol.3 (3), p.244-250 |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; Thieme Connect Journals Open Access; PubMed Central |
| subjects | Care and treatment Children & youth Convulsions & seizures Demographic aspects Diagnosis Epilepsy Epilepsy in children Health aspects Metabolic diseases Neurology Original Seizures (Medicine) |
| title | Characteristics of seizure frequency among Malaysian children diagnosed with structural-metabolic epilepsy |
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