5-HT3 Receptors

5-Hydroxytryptamine type 3 (5-HT3) receptors are cation-selective Cys loop receptors found in both the central and peripheral nervous systems. There are five 5-HT3 receptor subunits (A–E), and all functional receptors require at least one A subunit. Regions from noncontiguous parts of the subunit se...

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Veröffentlicht in:	The Journal of biological chemistry 2012-11, Vol.287 (48), p.40239-40245
1. Verfasser:	Lummis, Sarah C.R.
Format:	Artikel
Sprache:	eng
Schlagworte:	5-HT 5-Hydroxytryptamine Cys Loop Receptors Ligand-gated Ion Channel Membrane Biophysics Membrane Proteins Minireviews Receptors Serotonin
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description	5-Hydroxytryptamine type 3 (5-HT3) receptors are cation-selective Cys loop receptors found in both the central and peripheral nervous systems. There are five 5-HT3 receptor subunits (A–E), and all functional receptors require at least one A subunit. Regions from noncontiguous parts of the subunit sequence contribute to the agonist-binding site, and the roles of a range of amino acid residues that form the binding pocket have been identified. Drugs that selectively antagonize 5-HT3 receptors (the “setrons”) are the current gold standard for treatment of chemotherapy-induced and postoperative nausea and vomiting and have potential for the treatment of a range of other conditions.
doi_str_mv	10.1074/jbc.R112.406496
format	Article
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subjects	5-HT 5-Hydroxytryptamine Cys Loop Receptors Ligand-gated Ion Channel Membrane Biophysics Membrane Proteins Minireviews Receptors Serotonin
title	5-HT3 Receptors
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