Kuppfer Cells Trigger Nonalcoholic Steatohepatitis Development in Diet-induced Mouse Model through Tumor Necrosis Factor-α Production

Nonalcoholic steatohepatitis (NASH), characterized by lipid deposits within hepatocytes (steatosis), is associated with hepatic injury and inflammation and leads to the development of fibrosis, cirrhosis, and hepatocarcinoma. However, the pathogenic mechanism of NASH is not well understood. To deter...

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Veröffentlicht in:	The Journal of biological chemistry 2012-11, Vol.287 (48), p.40161-40172
Hauptverfasser:	Tosello-Trampont, Annie-Carole, Landes, Susan G., Nguyen, Virginia, Novobrantseva, Tatiana I., Hahn, Young S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chemokine CCL2 - genetics Chemokine CCL2 - immunology Chemokine CXCL10 - genetics Chemokine CXCL10 - immunology Choline - metabolism Diet - adverse effects Disease Models, Animal Fatty Liver - etiology Fatty Liver - genetics Fatty Liver - immunology Fatty Liver - metabolism Female Humans Immunology Inflammation Kupffer Cells - immunology Liver Injury Macrophages Methionine - deficiency Mice Mice, Inbred C57BL Monocytes Monocytes - immunology Non-alcoholic Fatty Liver Disease Nonalcoholic Steatohepatitis Tumor Necrosis Factor (TNF) Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - immunology
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