Tripartite Motif Containing 28 (Trim28) Can Regulate Cell Proliferation by Bridging HDAC1/E2F Interactions

Trim28 is a poorly understood transcriptional co-factor with pleiotropic biological activities. Although Trim28 mRNA is found in many studies to be up-regulated in both lung and breast cancer tissues relative to normal adjacent tissue, we found that within a panel of early-stage lung adenocarcinomas...

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Veröffentlicht in:	The Journal of biological chemistry 2012-11, Vol.287 (48), p.40106-40118
Hauptverfasser:	Chen, Lu, Chen, Dung-Tsa, Kurtyka, Courtney, Rawal, Bhupendra, Fulp, William J., Haura, Eric B., Cress, W.Douglas
Format:	Artikel
Sprache:	eng
Schlagworte:	Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - physiopathology Cancer Cell Cycle Cell Growth Cell Line, Tumor Cell Proliferation DNA - genetics DNA - metabolism E2F Transcription Factor E2F3 Transcription Factor - genetics E2F3 Transcription Factor - metabolism E2F4 Transcription Factor - genetics E2F4 Transcription Factor - metabolism Female Histone Deacetylase 1 - genetics Histone Deacetylase 1 - metabolism Humans Lung Cancer Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - physiopathology Male Molecular Bases of Disease Protein Binding Repressor Proteins - genetics Repressor Proteins - metabolism Tripartite Motif-Containing Protein 28
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