Vitamins E and C Alleviate the Germ Cell Loss and Oxidative Stress in Cryptorchidism When Administered Separately but Not When Combined in Rats
The antioxidant effects of vitamins C and E on cryptorchidism-induced oxidative stress were investigated in male Sprague-Dawley rats. Forty rats (200–250 g) were randomly divided in a blinded fashion into five groups (n=8). Group 1 was sham operated and treated with vehicle (corn-oil, 10 mL/kg). Gro...
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| creator | Afolabi, Ayobami Oladele Olotu, Olaolu Opeyemi Alagbonsi, Isiaka Abdullateef |
| description | The antioxidant effects of vitamins C and E on cryptorchidism-induced oxidative stress were investigated in male Sprague-Dawley rats. Forty rats (200–250 g) were randomly divided in a blinded fashion into five groups (n=8). Group 1 was sham operated and treated with vehicle (corn-oil, 10 mL/kg). Groups 2, 3, 4, and 5 were rendered unilaterally cryptorchid and treated with vehicle (10 mL/kg), vitamin E solution (75 mg/kg), vitamin C solution (1.25 g/kg), and combination of vitamin E (75 mg/kg) and vitamin C (1.25 g/kg) solutions, respectively. Germ cell count, superoxide dismutase (SOD), total protein (TP), and testicular weight (TW) were lower, but malondialdhyde (MDA) was higher in the cryptorchid rats than the sham-operated rats. When administered separately, vitamins C and E increased germ cell count, SOD, TP, and TW but did not reduce MDA in the cryptorchid rats when compared to the vehicle-treated cryptorchid rats. However, there was no significant difference in these parameters between vehicle-treated and combined vitamins C- and E-treated rats. This suggests that vitamins E and C alleviate the germ cell loss and oxidative stress in cryptorchidism when administered separately but not when combined in rats. |
| doi_str_mv | 10.5402/2012/843569 |
| format | Article |
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K.</contributor><creatorcontrib>Afolabi, Ayobami Oladele ; Olotu, Olaolu Opeyemi ; Alagbonsi, Isiaka Abdullateef ; Irie, T. ; Miller, D. K.</creatorcontrib><description>The antioxidant effects of vitamins C and E on cryptorchidism-induced oxidative stress were investigated in male Sprague-Dawley rats. Forty rats (200–250 g) were randomly divided in a blinded fashion into five groups (n=8). Group 1 was sham operated and treated with vehicle (corn-oil, 10 mL/kg). Groups 2, 3, 4, and 5 were rendered unilaterally cryptorchid and treated with vehicle (10 mL/kg), vitamin E solution (75 mg/kg), vitamin C solution (1.25 g/kg), and combination of vitamin E (75 mg/kg) and vitamin C (1.25 g/kg) solutions, respectively. Germ cell count, superoxide dismutase (SOD), total protein (TP), and testicular weight (TW) were lower, but malondialdhyde (MDA) was higher in the cryptorchid rats than the sham-operated rats. When administered separately, vitamins C and E increased germ cell count, SOD, TP, and TW but did not reduce MDA in the cryptorchid rats when compared to the vehicle-treated cryptorchid rats. However, there was no significant difference in these parameters between vehicle-treated and combined vitamins C- and E-treated rats. This suggests that vitamins E and C alleviate the germ cell loss and oxidative stress in cryptorchidism when administered separately but not when combined in rats.</description><identifier>ISSN: 2090-5165</identifier><identifier>ISSN: 2090-5173</identifier><identifier>EISSN: 2090-5173</identifier><identifier>DOI: 10.5402/2012/843569</identifier><identifier>PMID: 23213563</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Puplishing Corporation</publisher><subject>Antioxidants ; Ascorbic acid ; Cryptorchidism ; Germ cells ; Oxidative stress ; Rodents ; Superoxide dismutase ; Testes ; Vitamin C ; Vitamin E</subject><ispartof>ISRN pharmacology, 2012, Vol.2012 (2012), p.1-8</ispartof><rights>Copyright © 2012 Ayobami Oladele Afolabi et al.</rights><rights>Copyright © 2012 Ayobami Oladele Afolabi et al. Ayobami Oladele Afolabi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2012 Ayobami Oladele Afolabi et al. 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3779-9a3dcc0698b2f92f41ca45b22650e0a91385e34e48b184153edf1baf837d59753</citedby><cites>FETCH-LOGICAL-c3779-9a3dcc0698b2f92f41ca45b22650e0a91385e34e48b184153edf1baf837d59753</cites><orcidid>0000-0002-5462-9950</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3503317/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3503317/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,4024,27923,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23213563$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Irie, T.</contributor><contributor>Miller, D. K.</contributor><creatorcontrib>Afolabi, Ayobami Oladele</creatorcontrib><creatorcontrib>Olotu, Olaolu Opeyemi</creatorcontrib><creatorcontrib>Alagbonsi, Isiaka Abdullateef</creatorcontrib><title>Vitamins E and C Alleviate the Germ Cell Loss and Oxidative Stress in Cryptorchidism When Administered Separately but Not When Combined in Rats</title><title>ISRN pharmacology</title><addtitle>ISRN Pharmacol</addtitle><description>The antioxidant effects of vitamins C and E on cryptorchidism-induced oxidative stress were investigated in male Sprague-Dawley rats. Forty rats (200–250 g) were randomly divided in a blinded fashion into five groups (n=8). Group 1 was sham operated and treated with vehicle (corn-oil, 10 mL/kg). Groups 2, 3, 4, and 5 were rendered unilaterally cryptorchid and treated with vehicle (10 mL/kg), vitamin E solution (75 mg/kg), vitamin C solution (1.25 g/kg), and combination of vitamin E (75 mg/kg) and vitamin C (1.25 g/kg) solutions, respectively. Germ cell count, superoxide dismutase (SOD), total protein (TP), and testicular weight (TW) were lower, but malondialdhyde (MDA) was higher in the cryptorchid rats than the sham-operated rats. When administered separately, vitamins C and E increased germ cell count, SOD, TP, and TW but did not reduce MDA in the cryptorchid rats when compared to the vehicle-treated cryptorchid rats. However, there was no significant difference in these parameters between vehicle-treated and combined vitamins C- and E-treated rats. This suggests that vitamins E and C alleviate the germ cell loss and oxidative stress in cryptorchidism when administered separately but not when combined in rats.</description><subject>Antioxidants</subject><subject>Ascorbic acid</subject><subject>Cryptorchidism</subject><subject>Germ cells</subject><subject>Oxidative stress</subject><subject>Rodents</subject><subject>Superoxide dismutase</subject><subject>Testes</subject><subject>Vitamin C</subject><subject>Vitamin E</subject><issn>2090-5165</issn><issn>2090-5173</issn><issn>2090-5173</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqN0stu1DAUBmALgWg1dMUaZIkNAg31NYk3SKOoLUgjKlEuS8tJToirxBlsZ2Ceoq-MpykjYFOycRR_-eWc_Ag9peSNFISdMkLZaSG4zNQDdMyIIktJc_7wcJ_JI3QSwjVJlyRMFuwxOmKc0fQKP0Y3X2w0g3UBn2HjGlziVd_D1poIOHaAL8APuIS-x-sxhFty-dM2Jtot4KvoIT20Dpd-t4mjrzvb2DDgrx04vGpSrg0RPDT4CjbGp9B-h6sp4g9jnFE5DpV1CaSQjyaGJ-hRa_oAJ3frAn0-P_tUvluuLy_el6v1suZ5rpbK8KauSaaKirWKtYLWRsiKsUwSIEZRXkjgAkRR0UJQyaFpaWXagueNVLnkC_R2zt1M1QBNDS560-uNt4PxOz0aq__ecbbT38at5pJwnia8QC_vAvz4fYIQ9WBDnQZlHIxT0JQVkiglkv4_Snmy91PGBWfZ7QFe_EOvx8m7NLR9IGN5VjCR1OtZ1T79Pw_t4RMp0fsG6X2D9NygpJ__OZWD_d2XBF7NoLOuMT_sPWnPZgyJQGsOOPUwZ5L_AnVI1cE</recordid><startdate>2012</startdate><enddate>2012</enddate><creator>Afolabi, Ayobami Oladele</creator><creator>Olotu, Olaolu Opeyemi</creator><creator>Alagbonsi, Isiaka Abdullateef</creator><general>Hindawi Puplishing Corporation</general><general>International Scholarly Research Network</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>PADUT</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>7U7</scope><scope>C1K</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-5462-9950</orcidid></search><sort><creationdate>2012</creationdate><title>Vitamins E and C Alleviate the Germ Cell Loss and Oxidative Stress in Cryptorchidism When Administered Separately but Not When Combined in Rats</title><author>Afolabi, Ayobami Oladele ; Olotu, Olaolu Opeyemi ; Alagbonsi, Isiaka Abdullateef</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3779-9a3dcc0698b2f92f41ca45b22650e0a91385e34e48b184153edf1baf837d59753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Antioxidants</topic><topic>Ascorbic acid</topic><topic>Cryptorchidism</topic><topic>Germ cells</topic><topic>Oxidative stress</topic><topic>Rodents</topic><topic>Superoxide dismutase</topic><topic>Testes</topic><topic>Vitamin C</topic><topic>Vitamin E</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Afolabi, Ayobami Oladele</creatorcontrib><creatorcontrib>Olotu, Olaolu Opeyemi</creatorcontrib><creatorcontrib>Alagbonsi, Isiaka Abdullateef</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Research Library China</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>ISRN pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Afolabi, Ayobami Oladele</au><au>Olotu, Olaolu Opeyemi</au><au>Alagbonsi, Isiaka Abdullateef</au><au>Irie, T.</au><au>Miller, D. K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vitamins E and C Alleviate the Germ Cell Loss and Oxidative Stress in Cryptorchidism When Administered Separately but Not When Combined in Rats</atitle><jtitle>ISRN pharmacology</jtitle><addtitle>ISRN Pharmacol</addtitle><date>2012</date><risdate>2012</risdate><volume>2012</volume><issue>2012</issue><spage>1</spage><epage>8</epage><pages>1-8</pages><issn>2090-5165</issn><issn>2090-5173</issn><eissn>2090-5173</eissn><abstract>The antioxidant effects of vitamins C and E on cryptorchidism-induced oxidative stress were investigated in male Sprague-Dawley rats. Forty rats (200–250 g) were randomly divided in a blinded fashion into five groups (n=8). Group 1 was sham operated and treated with vehicle (corn-oil, 10 mL/kg). Groups 2, 3, 4, and 5 were rendered unilaterally cryptorchid and treated with vehicle (10 mL/kg), vitamin E solution (75 mg/kg), vitamin C solution (1.25 g/kg), and combination of vitamin E (75 mg/kg) and vitamin C (1.25 g/kg) solutions, respectively. Germ cell count, superoxide dismutase (SOD), total protein (TP), and testicular weight (TW) were lower, but malondialdhyde (MDA) was higher in the cryptorchid rats than the sham-operated rats. When administered separately, vitamins C and E increased germ cell count, SOD, TP, and TW but did not reduce MDA in the cryptorchid rats when compared to the vehicle-treated cryptorchid rats. However, there was no significant difference in these parameters between vehicle-treated and combined vitamins C- and E-treated rats. This suggests that vitamins E and C alleviate the germ cell loss and oxidative stress in cryptorchidism when administered separately but not when combined in rats.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Puplishing Corporation</pub><pmid>23213563</pmid><doi>10.5402/2012/843569</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-5462-9950</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Antioxidants Ascorbic acid Cryptorchidism Germ cells Oxidative stress Rodents Superoxide dismutase Testes Vitamin C Vitamin E |
| title | Vitamins E and C Alleviate the Germ Cell Loss and Oxidative Stress in Cryptorchidism When Administered Separately but Not When Combined in Rats |
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