Is NEDD4-1 a negative regulator of phosphatase and tensin homolog in gastric carcinogenesis

The expression of phosphatase and tensin homolog （PTEN ）, a tumor suppressor gene, is frequently downregulated in gastric carcinomas due to mutation, loss of heterozygosity, and promoter hypermethylation. However, it is unknown if additional mechanisms may account for the down-regulation of PTEN exp...

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Veröffentlicht in:	World journal of gastroenterology : WJG 2012-11, Vol.18 (43), p.6345-6348
Hauptverfasser:	Yang, Zhen, Yuan, Xiao-Gang, Chen, Jiang, Lu, Nong-Hua
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Biomarkers, Tumor - analysis Biopsy Cell Transformation, Neoplastic - chemistry Cell Transformation, Neoplastic - pathology Disease Progression Endosomal Sorting Complexes Required for Transport - analysis Female Gastric Mucosa - chemistry Gastric Mucosa - pathology Humans Immunohistochemistry Letters To The Editor Male Metaplasia Middle Aged Nedd4 Ubiquitin Protein Ligases N蛋白 PTEN PTEN Phosphohydrolase - analysis Stomach Neoplasms - chemistry Stomach Neoplasms - pathology Ubiquitin-Protein Ligases - analysis 同源物张力磷酸酶肿瘤抑制基因胃癌负调控因子
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