Telaprevir/boceprevir era： From bench to bed and back

Hepatitis C virus （HCV） infects approximately 200 million people worldwide. Interferon-based therapies have dominated over the past two decades. However, the overall response rates remain suboptimal. Thanks to the tremendous effort from both academia and industry, two serine protease inhibitors tela...

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Veröffentlicht in:	World journal of gastroenterology : WJG 2012-11, Vol.18 (43), p.6183-6188
Hauptverfasser:	Pan, Qiuwei, Peppelenbosch, Maikel P, Janssen, Harry L A, de Knegt, Robert J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiviral Agents - adverse effects Antiviral Agents - therapeutic use Drug Therapy, Combination Field Of Vision HCV Hepatitis C, Chronic - diagnosis Hepatitis C, Chronic - drug therapy Humans Oligopeptides - adverse effects Oligopeptides - therapeutic use Proline - adverse effects Proline - analogs & derivatives Proline - therapeutic use Translational Medical Research Treatment Outcome 丙型肝炎病毒丝氨酸蛋白酶抑制剂利巴韦林实验室治疗病毒感染组合使用
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