Safety and efficacy of tenofovir/IQP-0528 combination gels – A dual compartment microbicide for HIV-1 prevention

► Tenofovir/IQP-0528 microbicide combination gels were tested for safety and efficacy. ► Polarized ectocervical and colorectal tissues were used to evaluate these gels. ► Combination gels were safe toward mucosal tissue and blocked HIV infection. ► These gels provide the foundation of a dual compart...

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Veröffentlicht in:	Antiviral research 2012-11, Vol.96 (2), p.221-225
Hauptverfasser:	Dezzutti, Charlene S., Shetler, Cory, Mahalingam, Alamelu, Ugaonkar, Shweta R., Gwozdz, Garry, Buckheit, Karen W., Buckheit, Robert W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine - analogs & derivatives Adenine - pharmacology Adenine - toxicity Administration, Mucosal Anti-Infective Agents - pharmacology Anti-Infective Agents - toxicity Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Biological and medical sciences Cell Line Cell Survival - drug effects Chemoprevention - methods Combination microbicide Drug Therapy, Combination - methods Female HIV Infections - prevention & control HIV prevention HIV-1 - drug effects Human immunodeficiency virus 1 Human viral diseases Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Infectious diseases Medical sciences Organophosphonates - pharmacology Organophosphonates - toxicity Pharmacology. Drug treatments Pyrimidinedione Pyrimidinones - pharmacology Pyrimidinones - toxicity Rectal microbicide Tenofovir Tissue Culture Techniques Topical gel Vaginal Creams, Foams, and Jellies - pharmacology Vaginal Creams, Foams, and Jellies - toxicity Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids
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