Procontractile G protein-mediated signaling pathways antagonistically regulate smooth muscle differentiation in vascular remodeling

Vascular smooth muscle (Sm) cells (VSMCs) are highly plastic. Their differentiation state can be regulated by serum response factor (SRF), which activates genes involved in Sm differentiation and proliferation by recruiting cofactors, such as members of the myocardin family and ternary complex facto...

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Veröffentlicht in:	The Journal of experimental medicine 2012-11, Vol.209 (12), p.2277-2290
Hauptverfasser:	Althoff, Till F, Albarrán Juárez, Julián, Troidl, Kerstin, Tang, Cong, Wang, Shengpeng, Wirth, Angela, Takefuji, Mikito, Wettschureck, Nina, Offermanns, Stefan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apolipoproteins E - genetics Blood Pressure Blotting, Western Cell Differentiation - physiology DNA Primers - genetics Enzyme Activation - genetics Gene Expression Regulation - physiology GTP-Binding Proteins - deficiency GTP-Binding Proteins - genetics GTP-Binding Proteins - metabolism Guanine Nucleotide Exchange Factors - deficiency Guanine Nucleotide Exchange Factors - metabolism Immunohistochemistry Male Mice Mice, Knockout Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - physiology Real-Time Polymerase Chain Reaction Rho Guanine Nucleotide Exchange Factors Serum Response Factor - metabolism Signal Transduction - physiology Telemetry
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