Blocking IL-25 signalling protects against gut inflammation in a type-2 model of colitis by suppressing nuocyte and NKT derived IL-13

Background Interleukin-25 (IL-25) is a potent activator of type-2 immune responses. Mucosal inflammation in ulcerative colitis is driven by type-2 cytokines. We have previously shown that a neutralizing anti-IL-25 antibody abrogated airways hyperreactivity in an experimental model of lung allergy. T...

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Veröffentlicht in:	Journal of gastroenterology 2012-11, Vol.47 (11), p.1198-1211
Hauptverfasser:	Camelo, Ana, Barlow, Jillian L., Drynan, Lesley F., Neill, Daniel R., Ballantyne, Sarah J., Wong, See Heng, Pannell, Richard, Gao, Wei, Wrigley, Keely, Sprenkle, Justin, McKenzie, Andrew N. J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Abdominal Surgery Analysis Animals Antibodies, Neutralizing - administration & dosage Antibodies, Neutralizing - immunology Colitis, Ulcerative - immunology Colitis, Ulcerative - pathology Colorectal Surgery Cytokines Disease Models, Animal Female Gastroenterology Hepatology Immune response Immunoglobulin E Inflammation Inflammation - immunology Interleukin-13 - immunology Interleukin-17 - immunology Intestinal Mucosa - immunology Intestinal Mucosa - pathology Medicine Medicine & Public Health Mice Mice, Inbred BALB C Natural Killer T-Cells - immunology Original Article—Alimentary Tract Original —Alimentary Tract Oxazolone - toxicity Receptors, Interleukin-17 - immunology Signal Transduction - immunology Surgical Oncology Ulcerative colitis Weight loss
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