Surfactant protein D inhibits adherence of uropathogenic Escherichia coli to the bladder epithelial cells and the bacterium-induced cytotoxicity: a possible function in urinary tract

The adherence of uropathogenic Escherichia coli (UPEC) to the host urothelial surface is the first step for establishing UPEC infection. Uroplakin Ia (UPIa), a glycoprotein expressed on bladder urothelium, serves as a receptor for FimH, a lectin located at bacterial pili, and their interaction initi...

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Veröffentlicht in:	The Journal of biological chemistry 2012-11, Vol.287 (47), p.39578-39588
Hauptverfasser:	Kurimura, Yuichiro, Nishitani, Chiaki, Ariki, Shigeru, Saito, Atsushi, Hasegawa, Yoshihiro, Takahashi, Motoko, Hashimoto, Jiro, Takahashi, Satoshi, Tsukamoto, Taiji, Kuroki, Yoshio
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesins, Escherichia coli - genetics Adhesins, Escherichia coli - metabolism Animals Bacterial Adhesion Escherichia coli Infections - metabolism Escherichia coli Infections - pathology Female Fimbriae Proteins - genetics Fimbriae Proteins - metabolism Humans Immunology Male Mice Pulmonary Surfactant-Associated Protein D - genetics Pulmonary Surfactant-Associated Protein D - metabolism Rabbits Tetraspanins - biosynthesis Tetraspanins - genetics Urinary Bladder - metabolism Urinary Bladder - microbiology Urinary Bladder - pathology Urinary Tract Infections - metabolism Urinary Tract Infections - pathology Uropathogenic Escherichia coli - metabolism Uroplakin Ia - biosynthesis Uroplakin Ia - genetics Urothelium - metabolism Urothelium - microbiology Urothelium - pathology
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