Positional cloning of rp2 QTL associates the P450 genes CYP6Z1, CYP6Z3 and CYP6M7 with pyrethroid resistance in the malaria vector Anopheles funestus

Pyrethroid resistance in Anopheles funestus is threatening malaria control in Africa. Elucidation of underlying resistance mechanisms is crucial to improve the success of future control programs. A positional cloning approach was used to identify genes conferring resistance in the uncharacterised rp...

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Veröffentlicht in:	Heredity 2012-12, Vol.109 (6), p.383-392
Hauptverfasser:	Irving, H, Riveron, J M, Ibrahim, S S, Lobo, N F, Wondji, C S
Format:	Artikel
Sprache:	eng
Schlagworte:	Africa Amino acids Animals Anopheles - drug effects Anopheles - genetics Anopheles funestus Cloning Cloning, Molecular Cytochrome P-450 Enzyme System - genetics Cytochrome P-450 Enzyme System - metabolism Gene Expression Profiling Gene mapping Genetic Association Studies Genetics Humans Insecticide Resistance - genetics Insecticides Insecticides - toxicity Malaria Malaria - genetics Malaria - transmission Molecular Sequence Data Mosquitoes Original Polymorphism, Single Nucleotide Pyrethrins - toxicity Pyrethroids Quantitative Trait Loci - genetics Resistance to control Vector-borne diseases
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